PDB: 1551 件ウェブページステータス検索Chemie searchBIRD

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5XJQ	Crystal Structure of the Gemin2-binding domain of SMN, Gemin2 in Complex with SmD1(1-82)/D2/F/E/G from Human 分子名称: Gem-associated protein 2, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, ... 著者 Yi, H, Zhang, R. 登録日 2017-05-04 公開日 2018-07-04 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.28 Å) 主引用文献 Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly. Nucleic Acids Res., 2019
6PPN	Structure of S. pombe Lsm2-8 with unprocessed U6 snRNA 分子名称: Mimic of unprocessed U6 snRNA, Probable U6 snRNA-associated Sm-like protein LSm3, Probable U6 snRNA-associated Sm-like protein LSm4, ... 著者 Montemayor, E.J, Butcher, S.E. 登録日 2019-07-08 公開日 2020-06-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes. Rna, 26, 2020
6PPQ	Structure of S. pombe Lsm1-7 with RNA, polyuridine with 3' adenosine 分子名称: Probable U6 snRNA-associated Sm-like protein LSm3, Probable U6 snRNA-associated Sm-like protein LSm4, RNA (5'-R(*UP*UP*UP*UP*UP*A)-3'), ... 著者 Montemayor, E.J, Butcher, S.E. 登録日 2019-07-08 公開日 2020-06-17 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes. Rna, 26, 2020
6PPV	Structure of S. pombe Lsm1-7 with RNA, polyuridine with 3' guanosine 分子名称: Probable U6 snRNA-associated Sm-like protein LSm3, Probable U6 snRNA-associated Sm-like protein LSm4, RNA (5'-R(*AP*UP*UP*UP*UP*G)-3'), ... 著者 Montemayor, E.J, Butcher, S.E. 登録日 2019-07-08 公開日 2020-06-17 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes. Rna, 26, 2020
4F7U	The 6S snRNP assembly intermediate 分子名称: HEXAETHYLENE GLYCOL, Methylosome subunit pICln, Small nuclear ribonucleoprotein E, ... 著者 Grimm, C, Pelz, J.P. 登録日 2012-05-16 公開日 2013-01-30 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.898 Å) 主引用文献 Structural Basis of Assembly Chaperone- Mediated snRNP Formation. Mol.Cell, 49, 2013
7B0Y	Structure of a transcribing RNA polymerase II-U1 snRNP complex 分子名称: 145-nt RNA, DNA-directed RNA polymerase II subunit D, DNA-directed RNA polymerase II subunit E, ... 著者 Zhang, S, Aibara, S, Vos, S.M, Agafonov, D.E, Luehrmann, R, Cramer, P. 登録日 2020-11-23 公開日 2021-01-13 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structure of a transcribing RNA polymerase II-U1 snRNP complex. Science, 371, 2021
5XJS	Crystal Structure of the Gemin2-binding domain of SMN, Gemin2dN39 in Complex with SmD1(1-82)/D2/F/E from Human 分子名称: Gem-associated protein 2, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, ... 著者 Yi, H, Zhang, R. 登録日 2017-05-04 公開日 2018-07-04 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.38 Å) 主引用文献 Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly. Nucleic Acids Res., 2019
3LQV	Branch Recognition by SF3b14 分子名称: ADENINE, Pre-mRNA branch site protein p14, Splicing factor 3B subunit 1 著者 Schellenberg, M.J, MacMillan, A.M. 登録日 2010-02-10 公開日 2011-01-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Branch Recognition by SF3b14 Rna, 17, 2011
7OPI	Structure of a minimal SF3B core in complex with the inactive modulator spliceostatin E (form I) 分子名称: PHD finger-like domain-containing protein 5A, Spliceostatin E (form I), Splicing factor 3B subunit 1, ... 著者 Cretu, C, Pena, V. 登録日 2021-05-31 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. Nat Commun, 12, 2021
5VSU	Structure of yeast U6 snRNP with 2'-phosphate terminated U6 RNA 分子名称: Saccharomyces cerevisiae strain T8 chromosome XII sequence, U4/U6 snRNA-associated-splicing factor PRP24, U6 snRNA-associated Sm-like protein LSm2, ... 著者 Montemayor, E.J. 登録日 2017-05-12 公開日 2018-05-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Architecture of the U6 snRNP reveals specific recognition of 3'-end processed U6 snRNA. Nat Commun, 9, 2018
6ASO	Structure of yeast U6 snRNP with 3'-phosphate terminated U6 RNA 分子名称: MAGNESIUM ION, MANGANESE (II) ION, POTASSIUM ION, ... 著者 Montemayor, E.J, Brow, D.A, Butcher, S.E. 登録日 2017-08-25 公開日 2018-05-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Architecture of the U6 snRNP reveals specific recognition of 3'-end processed U6 snRNA. Nat Commun, 9, 2018
8ID2	Crystal structure of the ubiquitin-like domain in the SF3A1 subunit of human U2 snRNP complexed with the stem-loop 4 of U1 snRNA 分子名称: RNA (5'-R(*GP*GP*GP*GP*AP*CP*UP*GP*CP*GP*UP*UP*CP*GP*CP*GP*CP*UP*UP*UP*CP*CP*CP*C)-3'), Splicing factor 3A subunit 1 著者 Terawaki, S, Nameki, N, Kuwasako, K. 登録日 2023-02-12 公開日 2023-05-17 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural insights into recognition of SL4, the UUCG stem-loop, of human U1 snRNA by the ubiquitin-like domain, including the C-terminal tail in the SF3A1 subunit of U2 snRNP. J.Biochem., 174, 2023
7OMF	Structure of a minimal SF3B core in complex with sudemycin D6 (form I) 分子名称: PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3, ... 著者 Cretu, C, Pena, V. 登録日 2021-05-21 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. Nat Commun, 12, 2021
6TEO	Crystal structure of a yeast Snu114-Prp8 complex 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Pre-mRNA-splicing factor 8, ... 著者 Ganichkin, O, Jia, J, Loll, B, Absmeier, E, Wahl, M.C. 登録日 2019-11-12 公開日 2020-03-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A Snu114-GTP-Prp8 module forms a relay station for efficient splicing in yeast. Nucleic Acids Res., 48, 2020
8G1U	Structure of the methylosome-Lsm10/11 complex 分子名称: ADENOSINE, Methylosome protein 50, Methylosome subunit pICln, ... 著者 Lin, M, Paige, A, Tong, L. 登録日 2023-02-03 公開日 2023-08-23 最終更新日 2023-10-25 実験手法 ELECTRON MICROSCOPY (2.83 Å) 主引用文献 In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome. Rna, 29, 2023
3SWN	Structure of the LSm657 Complex: An Assembly Intermediate of the LSm1 7 and LSm2 8 Rings 分子名称: U6 snRNA-associated Sm-like protein LSm5, U6 snRNA-associated Sm-like protein LSm6, U6 snRNA-associated Sm-like protein LSm7, ... 著者 Mund, M, Neu, A, Ullmann, J.L, Neu, U, Sprangers, R. 登録日 2011-07-14 公開日 2011-10-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of the LSm657 complex: an assembly intermediate of the LSm1-7 and LSm2-8 rings. J.Mol.Biol., 414, 2011
7ZNK	Structure of an endogenous human TREX complex bound to mRNA 分子名称: RNA, Spliceosome RNA helicase DDX39B, THO complex subunit 1, ... 著者 Pacheco-Fiallos, F.B, Vorlaender, M.K, Plaschka, C. 登録日 2022-04-21 公開日 2023-05-03 最終更新日 2023-05-24 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 mRNA recognition and packaging by the human transcription-export complex. Nature, 616, 2023
7B0I	Structure of a minimal SF3B core in complex with spliceostatin A (form II) 分子名称: PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3,Splicing factor 3B subunit 3,Splicing factor 3B subunit 3, ... 著者 Cretu, C, Pena, V. 登録日 2020-11-19 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. Nat Commun, 12, 2021
2X7K	The crystal structure of PPIL1 in complex with cyclosporine A suggests a binding mode for SKIP 分子名称: CADMIUM ION, CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 1, ... 著者 Stegmann, C.M, Luehrmann, R, Wahl, M.C. 登録日 2010-03-01 公開日 2010-03-23 最終更新日 2019-10-16 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 The Crystal Structure of Ppil1 Bound to Cyclosporine a Suggests a Binding Mode for a Linear Epitope of the Skip Protein. Plos One, 5, 2010
3SBT	Crystal structure of a Aar2-Prp8 complex 分子名称: A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8, S-1,2-PROPANEDIOL, ... 著者 Weber, G, Santos, K.F, Holton, N, Wahl, M.C. 登録日 2011-06-06 公開日 2011-07-27 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.799 Å) 主引用文献 Mechanism for Aar2p function as a U5 snRNP assembly factor. Genes Dev., 25, 2011
2VY4	U11-48K CHHC ZN-FINGER DOMAIN 分子名称: U11/U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 48 KDA PROTEIN, ZINC ION 著者 Tidow, H, Andreeva, A, Rutherford, T.J, Fersht, A.R. 登録日 2008-07-17 公開日 2009-02-17 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution structure of the U11-48K CHHC zinc-finger domain that specifically binds the 5' splice site of U12-type introns. Structure, 17, 2009
7B92	Structure of a minimal SF3B core in complex with sudemycin D6 (form II) 分子名称: PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3, ... 著者 Cretu, C, Pena, V. 登録日 2020-12-14 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. Nat Commun, 12, 2021
7B9C	Structure of a minimal SF3B core in complex with spliceostatin A (form I) 分子名称: PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3, ... 著者 Cretu, C, Pena, V. 登録日 2020-12-14 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. Nat Commun, 12, 2021
7B91	Structure of a minimal SF3B core in complex with pladienolide D (form I) 分子名称: PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3, ... 著者 Cretu, C, Pena, V. 登録日 2020-12-13 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. Nat Commun, 12, 2021
3PLV	Structure of Hub-1 protein in complex with Snu66 peptide (HINDII) 分子名称: 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component, Ubiquitin-like modifier HUB1 著者 Mishra, S.K, Ammon, T, Popowicz, G.M, Krajewski, M, Nagel, R.J, Ares, M, Holak, T.A, Jentsch, S. 登録日 2010-11-15 公開日 2011-06-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing. Nature, 474, 2011

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