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PDB: 24 件
8BA5
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BU of 8ba5 by Molmil
Crystal structure of the DNMT3A ADD domain
分子名称: 1,2-ETHANEDIOL, DNA (cytosine-5)-methyltransferase 3A, MAGNESIUM ION, ...
著者Linhard, V, Kunert, S, Wollenhaupt, J, Broehm, A, Schwalbe, H, Jeltsch, A.
登録日2022-10-11
公開日2022-11-23
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献The MECP2-TRD domain interacts with the DNMT3A-ADD domain at the H3-tail binding site.
Protein Sci., 32, 2023
4QBS
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BU of 4qbs by Molmil
Crystal structure of DNMT3a ADD domain E545R mutant bound to H3T3ph peptide
分子名称: DNA (cytosine-5)-methyltransferase 3A, Histone H3, SULFATE ION, ...
著者Wang, H, Li, H.
登録日2014-05-08
公開日2015-05-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Engineering of a histone-recognition domain in a de novo DNA methyltransferase alters the epigenetic landscape of ESCs
To be Published
4QBR
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BU of 4qbr by Molmil
Crystal structure of DNMT3a ADD domain G550D mutant bound to H3 peptide
分子名称: DNA (cytosine-5)-methyltransferase 3A, Histone H3, ZINC ION
著者Wang, H, Li, H.
登録日2014-05-08
公開日2015-05-13
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.902 Å)
主引用文献Engineering of a histone-recognition domain in a de novo DNA methyltransferase alters the epigenetic landscape of ESCs
To be Published
3A1B
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BU of 3a1b by Molmil
Crystal structure of the DNMT3A ADD domain in complex with histone H3
分子名称: 1,2-ETHANEDIOL, DNA (cytosine-5)-methyltransferase 3A, Histone H3.1, ...
著者Otani, J, Arita, K, Ariyoshi, M, Shirakawa, M.
登録日2009-03-28
公開日2009-11-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.292 Å)
主引用文献Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain
Embo Rep., 10, 2009
3A1A
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BU of 3a1a by Molmil
Crystal Structure of the DNMT3A ADD domain
分子名称: 1,2-ETHANEDIOL, DNA (cytosine-5)-methyltransferase 3A, ZINC ION
著者Otani, J, Arita, K, Ariyoshi, M, Shirakawa, M.
登録日2009-03-28
公開日2009-11-10
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain
Embo Rep., 10, 2009
3LLR
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BU of 3llr by Molmil
Crystal structure of the PWWP domain of Human DNA (cytosine-5-)-methyltransferase 3 alpha
分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA (cytosine-5)-methyltransferase 3A, SULFATE ION
著者Qiu, W, Dombrovski, L, Ni, S, Weigelt, J, Boutra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC)
登録日2010-01-29
公開日2010-03-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural and histone binding ability characterizations of human PWWP domains.
Plos One, 6, 2011
3SVM
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BU of 3svm by Molmil
Human MPP8 - human DNMT3AK47me2 peptide
分子名称: DNA (cytosine-5)-methyltransferase 3A, M-phase phosphoprotein 8
著者Chang, Y, Horton, J.R, Zhang, X, Cheng, X.
登録日2011-07-12
公開日2011-11-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.
Nat Commun, 2, 2011
6W8B
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BU of 6w8b by Molmil
Structure of DNMT3A in complex with CGA DNA
分子名称: CGA DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ...
著者Anteneh, H, Song, J.
登録日2020-03-20
公開日2020-04-15
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation.
Nat Commun, 11, 2020
4QBQ
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BU of 4qbq by Molmil
Crystal structure of DNMT3a ADD domain bound to H3 peptide
分子名称: DNA (cytosine-5)-methyltransferase 3A, Histone H3, ZINC ION
著者Li, H, Patel, D.J.
登録日2014-05-08
公開日2015-05-13
実験手法X-RAY DIFFRACTION (2.406 Å)
主引用文献Engineering of a histone-recognition domain in a de novo DNA methyltransferase alters the epigenetic landscape of ESCs
To be Published
6W8J
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BU of 6w8j by Molmil
Structure of DNMT3A (R882H) in complex with CAG DNA
分子名称: CAG DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ...
著者Anteneh, H, Song, J.
登録日2020-03-20
公開日2020-04-15
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.445 Å)
主引用文献Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation.
Nat Commun, 11, 2020
8TE1
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BU of 8te1 by Molmil
Crystal structure of the methyltransferase domain of R882H/R676K DNMT3A homotetramer
分子名称: DNA (cytosine-5)-methyltransferase 3A, GLYCEROL, L(+)-TARTARIC ACID, ...
著者Lu, J.W, Song, J.K.
登録日2023-07-05
公開日2024-03-13
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Crystal structure of the methyltransferase domain of R882H/R676K DNMT3A homotetramer
To Be Published
6W89
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BU of 6w89 by Molmil
Structure of DNMT3A (R882H) in complex with CGA DNA
分子名称: CGA DNA (25-MER), CITRIC ACID, DNA (cytosine-5)-methyltransferase 3-like, ...
著者Anteneh, H, Song, J.
登録日2020-03-20
公開日2020-04-15
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.499 Å)
主引用文献Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation.
Nat Commun, 11, 2020
6W8D
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BU of 6w8d by Molmil
Structure of DNMT3A (R882H) in complex with CGT DNA
分子名称: CGT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ...
著者Anteneh, H, Song, J.
登録日2020-03-20
公開日2020-04-15
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.598 Å)
主引用文献Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation.
Nat Commun, 11, 2020
8TE4
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BU of 8te4 by Molmil
Crystal structure of the methyltransferase domain of R882H/N879A DNMT3A homotetramer
分子名称: DNA (cytosine-5)-methyltransferase 3A, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE
著者Lu, J.W, Song, J.K.
登録日2023-07-05
公開日2024-03-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Crystal structure of the methyltransferase domain of R882H/N879A DNMT3A homotetramer
To Be Published
5YX2
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BU of 5yx2 by Molmil
Crystal structure of DNMT3A-DNMT3L in complex with DNA containing two CpG sites
分子名称: DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ...
著者Zhang, Z.M, Song, J.
登録日2017-12-01
公開日2018-01-31
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.653 Å)
主引用文献Structural basis for DNMT3A-mediated de novo DNA methylation.
Nature, 554, 2018
2QRV
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BU of 2qrv by Molmil
Structure of Dnmt3a-Dnmt3L C-terminal domain complex
分子名称: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE
著者Jia, D, Cheng, X.
登録日2007-07-29
公開日2007-12-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation.
Nature, 449, 2007
4U7T
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BU of 4u7t by Molmil
Crystal structure of DNMT3A-DNMT3L in complex with histone H3
分子名称: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Guo, X, Wang, L, Yin, X, Li, J, Xiao, J, He, S, Wang, J, Xu, Y.
登録日2014-07-31
公開日2014-11-12
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural insight into autoinhibition and histone H3-induced activation of DNMT3A
Nature, 517, 2015
6PA7
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BU of 6pa7 by Molmil
The cryo-EM structure of the human DNMT3A2-DNMT3B3 complex bound to nucleosome.
分子名称: CHLORIDE ION, DNA (167-MER), DNA (cytosine-5)-methyltransferase 3A, ...
著者Xu, T.H, Liu, M, Zhou, X.E, Liang, G, Zhao, G, Xu, H.E, Melcher, K, Jones, P.A.
登録日2019-06-11
公開日2020-06-17
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B.
Nature, 586, 2020
6BRR
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BU of 6brr by Molmil
Crystal structure of DNMT3A (R836A)-DNMT3L in complex with DNA containing two CpG sites
分子名称: DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ...
著者Zhang, Z.M, Song, J.
登録日2017-11-30
公開日2018-01-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.97 Å)
主引用文献Structural basis for DNMT3A-mediated de novo DNA methylation.
Nature, 554, 2018
6F57
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BU of 6f57 by Molmil
Crystal structure of DNMT3A-DNMT3L in complex with single CpG-containing DNA
分子名称: DNA (5'-D(*AP*GP*AP*GP*CP*GP*CP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*GP*ZP*GP*CP*TP*CP*T)-3'), DNA (cytosine-5)-methyltransferase 3-like, ...
著者Zhang, Z.M, Song, J.
登録日2017-12-01
公開日2018-01-31
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.098 Å)
主引用文献Structural basis for DNMT3A-mediated de novo DNA methylation.
Nature, 554, 2018
8TE3
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BU of 8te3 by Molmil
Crystal structure of the methyltransferase domain of R882C/R676K DNMT3A homotetramer
分子名称: DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE
著者Lu, J.W, Song, J.K.
登録日2023-07-05
公開日2024-03-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structure of the homo-tetrameric DNMT3A methyltransferase domain(R882C/R676K)
To Be Published
8U5H
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BU of 8u5h by Molmil
Cryo-EM structure of human DNMT3A UDR bound to H2AK119ub1-modified nucleosome
分子名称: DNA (cytosine-5)-methyltransferase 3A, Histone H2A, Histone H2B 1.1, ...
著者Chen, X, Song, J.
登録日2023-09-12
公開日2024-06-12
実験手法ELECTRON MICROSCOPY (3.23 Å)
主引用文献Cryo-EM structure of human DNMT3A N-terminal domain bound to H2AK119Ub nucleosome
To Be Published
8TDR
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BU of 8tdr by Molmil
Crystal structure of the methyltransferase domain of DNMT3A homotetramer
分子名称: DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE
著者Lu, J.W, Song, J.K.
登録日2023-07-04
公開日2024-03-13
実験手法X-RAY DIFFRACTION (3.32 Å)
主引用文献Crystal structure of the homo-tetrameric DNMT3A methyltransferase domain
To Be Published
4U7P
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BU of 4u7p by Molmil
Crystal structure of DNMT3A-DNMT3L complex
分子名称: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Wang, L, Guo, X, Li, J, Xiao, J, Yin, X, He, S, Wang, J, Xu, Y.
登録日2014-07-31
公開日2014-11-12
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.821 Å)
主引用文献Structural insight into autoinhibition and histone H3-induced activation of DNMT3A
Nature, 517, 2015

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