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PDB: 236 件
6D0M
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BU of 6d0m by Molmil
Polymerase Eta post-insertion binary complex with cytarabine (AraC)
分子名称: DNA (5'-D(*CP*AP*TP*GP*AP*CP*AP*GP*TP*GP*CP*T)-3'), DNA polymerase eta, DNA/RNA (5'-D(*AP*GP*CP*AP*CP*TP*GP*T)-R(P*(CAR))-3'), ...
著者Rechkoblit, O, Aggarwal, A.K.
登録日2018-04-10
公開日2018-09-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.832 Å)
主引用文献Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine.
Sci Rep, 8, 2018
4ECZ
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BU of 4ecz by Molmil
Human DNA polymerase eta - DNA ternary complex: AT crystal at pH 6.5 (Na+ MES) with 1 Ca2+ ion
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Nakamura, T, Zhao, Y, Yang, W.
登録日2012-03-26
公開日2012-07-11
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.834 Å)
主引用文献Watching DNA polymerase eta make a phosphodiester bond
Nature, 487, 2012
7M87
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BU of 7m87 by Molmil
Human DNA Pol eta S113A with dA-ended primer and dATP: in crystallo reaction for 230 s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ...
著者Gregory, M.T, Gao, Y, Yang, W.
登録日2021-03-29
公開日2021-06-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M8B
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BU of 7m8b by Molmil
Human DNA Pol eta S113A with rA-ended primer and dATP: in crystallo reaction for 140 s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ...
著者Gregory, M.T, Gao, Y, Yang, W.
登録日2021-03-29
公開日2021-06-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M7S
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BU of 7m7s by Molmil
Human DNA Pol eta S113A with dT-ended primer and 0.1 mM dAMPNPP
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Gregory, M.T, Gao, Y, Yang, W.
登録日2021-03-28
公開日2021-06-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M8C
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BU of 7m8c by Molmil
Human DNA Pol eta S113A with rA-ended primer and dATP: in crystallo reaction for 230 s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ...
著者Gregory, M.T, Gao, Y, Yang, W.
登録日2021-03-29
公開日2021-06-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.
Proc.Natl.Acad.Sci.USA, 118, 2021
4J9L
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BU of 4j9l by Molmil
Human DNA polymerase eta-DNA ternary complex: misincorporation G opposite T after a C at the primer 3' end (CA/G)
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA, DNA polymerase eta, ...
著者Zhao, Y, Gregory, M, Biertumpfel, C, Hua, Y, Hanaoka, F, Yang, W.
登録日2013-02-16
公開日2013-05-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
Proc.Natl.Acad.Sci.USA, 110, 2013
4YP3
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BU of 4yp3 by Molmil
Mutant Human DNA Polymerase Eta Q38A/R61A Inserting dCTP Opposite an 8-Oxoguanine Lesion
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P.
登録日2015-03-12
公開日2015-05-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
4ECR
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BU of 4ecr by Molmil
Human DNA polymerase eta - DNA ternary complex: Reaction in the AT crystal at pH 7.0 for 40 sec
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Nakamura, T, Zhao, Y, Yang, W.
登録日2012-03-26
公開日2012-07-11
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.892 Å)
主引用文献Watching DNA polymerase eta make a phosphodiester bond
Nature, 487, 2012
4ECW
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BU of 4ecw by Molmil
Human DNA polymerase eta - DNA ternary complex: Reaction in the AT crystal at pH 7.0 for 250 sec
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ...
著者Nakamura, T, Zhao, Y, Yang, W.
登録日2012-03-26
公開日2012-07-11
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.896 Å)
主引用文献Watching DNA polymerase eta make a phosphodiester bond
Nature, 487, 2012
5L9X
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BU of 5l9x by Molmil
Human DNA polymerase eta-DNA ternary complex: reaction with 10 mM Mn2+ for 60s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ...
著者Gao, Y, Yang, W.
登録日2016-06-12
公開日2016-06-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Capture of a third Mg2+ is essential for catalyzing DNA synthesis.
Science, 352, 2016
3MR6
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BU of 3mr6 by Molmil
Human DNA polymerase eta - DNA ternary complex with a CPD 2bp upstream of the active site (TT4)
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*C*AP*TP*CP*AP*(TTD)P*AP*CP*GP*AP*GP*C)-3'), DNA (5'-D(*TP*CP*TP*CP*GP*TP*AP*AP*T)-3'), ...
著者Biertumpfel, C, Zhao, Y, Ramon-Maiques, S, Gregory, M.T, Lee, J.Y, Yang, W.
登録日2010-04-28
公開日2010-06-30
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure and mechanism of human DNA polymerase eta.
Nature, 465, 2010
8V7B
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BU of 8v7b by Molmil
Human DNA polymerase eta-DNA-dT primer araCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion
分子名称: 4-amino-1-{5-O-[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}pyrimidin-2(1H)-one, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), ...
著者Chang, C, Gao, Y.
登録日2023-12-04
公開日2024-05-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Human DNA polymerase eta-DNA-dT primer araCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion
To Be Published
6MP3
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BU of 6mp3 by Molmil
Binary structure of DNA polymerase eta in complex with templating hypoxanthine
分子名称: DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*IP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ...
著者Hawkins, M.A, Jung, H, Lee, S.
登録日2018-10-05
公開日2019-10-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.907 Å)
主引用文献Structural Analysis of Translesion Synthesis Across Hypoxanthine Lesion Using Human DNA Polymerase Eta
To Be Published
7M8A
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BU of 7m8a by Molmil
Human DNA Pol eta S113A with rA-ended primer and dATP: in crystallo reaction for 40 s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ...
著者Gregory, M.T, Gao, Y, Yang, W.
登録日2021-03-29
公開日2021-06-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.
Proc.Natl.Acad.Sci.USA, 118, 2021
7L69
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BU of 7l69 by Molmil
Crystal structure of human polymerase eta complexed with syn N7-benzylguanine
分子名称: DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*AP*TP*(7BG)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), DNA polymerase eta
著者Jung, H, Lee, S.
登録日2020-12-23
公開日2022-01-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Crystal structure of human polymerase eta complexed with syn N7-benzylguanine
To Be Published
7M8D
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BU of 7m8d by Molmil
Human DNA Pol eta S113A with rA-ended primer and dATP: in crystallo reaction for 300 s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Gregory, M.T, Gao, Y, Yang, W.
登録日2021-03-29
公開日2021-06-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M7U
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BU of 7m7u by Molmil
Human DNA Pol eta S113A with dT-ended primer and dATP: in crystallo reaction for 480s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Gregory, M.T, Gao, Y, Yang, W.
登録日2021-03-28
公開日2021-06-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.
Proc.Natl.Acad.Sci.USA, 118, 2021
5L1J
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BU of 5l1j by Molmil
Crystal Structure of Human DNA Polymerase Eta Inserting dTMPNPP Opposite O6-Methyl-2'-deoxyguanosine
分子名称: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(6OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Patra, A, Egli, M.
登録日2016-07-29
公開日2016-10-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2'-deoxyguanosine by Human DNA Polymerase eta.
J.Biol.Chem., 291, 2016
4ECY
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BU of 4ecy by Molmil
Human DNA polymerase eta - DNA ternary complex: AT crystal at pH 6.0 (Na+ MES) with 1 Ca2+ ion
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Nakamura, T, Zhao, Y, Yang, W.
登録日2012-03-26
公開日2012-07-11
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.943 Å)
主引用文献Watching DNA polymerase eta make a phosphodiester bond
Nature, 487, 2012
4ECU
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BU of 4ecu by Molmil
Human DNA polymerase eta - DNA ternary complex: Reaction in the AT crystal at pH 7.0 for 200 sec
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ...
著者Nakamura, T, Zhao, Y, Yang, W.
登録日2012-03-26
公開日2012-07-11
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.949 Å)
主引用文献Watching DNA polymerase eta make a phosphodiester bond
Nature, 487, 2012
8V7A
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BU of 8v7a by Molmil
Human DNA polymerase eta-DNA-dT primer dCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), ...
著者Chang, C, Gao, Y.
登録日2023-12-04
公開日2024-05-15
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Human DNA polymerase eta-DNA-dT primer dCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion
To Be Published
8V7D
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BU of 8v7d by Molmil
Human DNA polymerase eta-DNA-dT primer rCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion
分子名称: CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), ...
著者Chang, C, Gao, Y.
登録日2023-12-04
公開日2024-05-15
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Human DNA polymerase eta-DNA-dT primer rCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion
To Be Published
4J9S
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BU of 4j9s by Molmil
Human DNA polymerase eta-DNA translocated binary complex: with TA base pair
分子名称: DNA (5'-D(*T*AP*TP*TP*TP*AP*TP*GP*AP*CP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*GP*TP*CP*AP*TP*A)-3'), DNA polymerase eta, ...
著者Zhao, Y, Gregory, M, Biertumpfel, C, Hua, Y, Hanaoka, F, Yang, W.
登録日2013-02-16
公開日2013-05-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
Proc.Natl.Acad.Sci.USA, 110, 2013
4YR2
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BU of 4yr2 by Molmil
Mutant Human DNA Polymerase Eta R61M Inserting dATP Opposite an 8-Oxoguanine Lesion
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P.
登録日2015-03-14
公開日2015-05-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015

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