6KI0
| Crystal Structure of Human ASC-CARD | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Apoptosis-associated speck-like protein containing a CARD, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Xu, Z.H, Jin, T.C. | 登録日 | 2019-07-16 | 公開日 | 2020-07-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome. Cell Death Dis, 12, 2021
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7E5B
| Crystal structure of ASC PYD Domain and Rb-B7 | 分子名称: | Apoptosis-associated speck-like protein containing a CARD, GLYCEROL, Repebody (Rb-B7) | 著者 | Cho, H.S, Cha, J.S. | 登録日 | 2021-02-18 | 公開日 | 2022-03-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Oligomeric states of ASC specks regulate inflammatory responses by inflammasome in the extracellular space. Cell Death Discov, 9, 2023
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6N1H
| Cryo-EM structure of ASC-CARD filament | 分子名称: | Apoptosis-associated speck-like protein containing a CARD | 著者 | Li, Y, Fu, T, Wu, H. | 登録日 | 2018-11-08 | 公開日 | 2018-12-05 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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3J63
| Unified assembly mechanism of ASC-dependent inflammasomes | 分子名称: | Apoptosis-associated speck-like protein containing a CARD | 著者 | Lu, A, Magupalli, V.G, Ruan, J, Yin, Q, Atianand, M.K, Vos, M, Schroder, G.F, Fitzgerald, K.A, Wu, H, Egelman, E.H. | 登録日 | 2013-12-05 | 公開日 | 2014-03-26 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes. Cell(Cambridge,Mass.), 156, 2014
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7KEU
| Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer | 分子名称: | Apoptosis-associated speck-like protein containing a CARD, Caspase-1 | 著者 | Hollingsworth, L.R, David, L, Li, Y, Ruan, J, Wu, H. | 登録日 | 2020-10-12 | 公開日 | 2020-11-25 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nat Commun, 12, 2021
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6K99
| Structure of ASC CARD filament | 分子名称: | Apoptosis-associated speck-like protein containing a CARD | 著者 | Gong, Q, Xu, C, Zhang, J, Boo, Z.Z, Wu, B. | 登録日 | 2019-06-14 | 公開日 | 2020-09-16 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8. Nat Commun, 12, 2021
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5H8O
| Crystal structure of an ASC-binding nanobody in complex with the CARD domain of ASC | 分子名称: | Apoptosis-associated speck-like protein containing a CARD, VHH nanobody | 著者 | Lu, A, Schmidt, F.I, Ruan, J, Tang, C, Wu, H, Ploegh, H.L. | 登録日 | 2015-12-23 | 公開日 | 2016-04-06 | 最終更新日 | 2016-05-18 | 実験手法 | X-RAY DIFFRACTION (4.206 Å) | 主引用文献 | A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. J.Exp.Med., 213, 2016
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1UCP
| NMR structure of the PYRIN domain of human ASC | 分子名称: | Apoptosis-associated speck-like protein containing a CARD | 著者 | Liepinsh, E, Barbals, R, Dahl, E, Sharipo, A, Staub, E, Otting, G. | 登録日 | 2003-04-16 | 公開日 | 2003-11-04 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition J.Mol.Biol., 332, 2003
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2KN6
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