8BL1
 
 | | Human Sirt6 in complex with the inhibitor S6039 and ADP-ribose | | 分子名称: | 2-azanyl-5-[4-[[5-(2-fluorophenyl)thiophen-2-yl]methyl]piperazin-1-yl]sulfonyl-benzenesulfonamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | You, W, Steegborn, C. | | 登録日 | 2022-11-09 | | 公開日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen
To Be Published
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5MGN
 | | Human Sirt6 in complex with activator UBCS38 | | 分子名称: | (4~{R})-4-pyridin-3-yl-5-[3-(trifluoromethyl)phenyl]sulfonyl-4~{H}-pyrrolo[1,2-a]quinoxaline, 1,2-ETHANEDIOL, NAD-dependent protein deacetylase sirtuin-6, ... | | 著者 | Steegborn, C, You, W, Kambach, C. | | 登録日 | 2016-11-21 | | 公開日 | 2016-12-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.
Angew. Chem. Int. Ed. Engl., 56, 2017
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5MFZ
 | | Human Sirt6 in complex with small molecule UBCS40 | | 分子名称: | 1,2-ETHANEDIOL, 1-pyrrolo[1,2-a]quinoxalin-4-ylnaphthalen-2-ol, NAD-dependent protein deacetylase sirtuin-6, ... | | 著者 | Steegborn, C, You, W, Kambach, C. | | 登録日 | 2016-11-19 | | 公開日 | 2016-12-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.
Angew. Chem. Int. Ed. Engl., 56, 2017
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6XVG
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6QCH
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8AK5
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3PKJ
 | | Human SIRT6 crystal structure in complex with 2'-N-Acetyl ADP ribose | | 分子名称: | NAD-dependent deacetylase sirtuin-6, SULFATE ION, UNKNOWN ATOM OR ION, ... | | 著者 | Pan, P.W, Dong, A, Qiu, W, Loppnau, P, Wang, J, Ravichandran, M, Walker, J.R, Bountra, C, Weigelt, J, Arrowsmith, C.H, Min, J, Edwards, A.M, Structural Genomics Consortium (SGC) | | 登録日 | 2010-11-11 | | 公開日 | 2011-01-26 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Structure and biochemical functions of SIRT6.
J.Biol.Chem., 286, 2011
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6XUY
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8AKB
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8I2B
 | | Human SIRT6 in complex with inhibitor 7702 | | 分子名称: | N1-[[4-(4-aminophenyl)sulfanyl-3-(trifluoromethyl)phenyl]methoxy]benzene-1,4-dicarboxamide, NAD-dependent protein deacylase sirtuin-6, SULFATE ION, ... | | 著者 | Wang, Y. | | 登録日 | 2023-01-14 | | 公開日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The SIRT6 in complex with inhibitor 7702
To Be Published
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3ZG6
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6ZU4
 | | Human Sirt6 13-308 in complex with ADP-ribose and the activator fluvastatin | | 分子名称: | (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid, GLYCEROL, NAD-dependent protein deacetylase sirtuin-6, ... | | 著者 | You, W, Steegborn, C. | | 登録日 | 2020-07-21 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Structural Basis for Activation of Human Sirtuin 6 by Fluvastatin.
Acs Med.Chem.Lett., 11, 2020
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7CL0
 | | Crystal structure of human SIRT6 | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, NAD-dependent protein deacetylase sirtuin-6, ... | | 著者 | Song, K, Zhang, J. | | 登録日 | 2020-07-20 | | 公開日 | 2021-02-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | Reply to: Binding site for MDL-801 on SIRT6.
Nat.Chem.Biol., 17, 2021
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5Y2F
 | | Human SIRT6 in complex with allosteric activator MDL-801 | | 分子名称: | 5-[[3,5-bis(chloranyl)phenyl]sulfonylamino]-2-[(5-bromanyl-4-fluoranyl-2-methyl-phenyl)sulfamoyl]benzoic acid, 9-mer peptide QTARKSTGG, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Zhang, J, Huang, Z, Song, K. | | 登録日 | 2017-07-25 | | 公開日 | 2018-11-07 | | 最終更新日 | 2018-11-28 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | Identification of a cellularly active SIRT6 allosteric activator.
Nat. Chem. Biol., 14, 2018
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8OF4
 | | Nucleosome Bound human SIRT6 (Composite) | | 分子名称: | DNA (145-MER), Histone H2A type 1, Histone H2B, ... | | 著者 | Smirnova, E, Bignon, E, Schultz, P, Papai, G, Ben-Shem, A. | | 登録日 | 2023-03-13 | | 公開日 | 2023-08-09 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | | 主引用文献 | Binding to nucleosome poises human SIRT6 for histone H3 deacetylation.
Elife, 12, 2024
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8G57
 | | Structure of nucleosome-bound Sirtuin 6 deacetylase | | 分子名称: | DNA strand 1, DNA strand 2, Histone H2A type 1-B/E, ... | | 著者 | Chio, U.S, Rechiche, O, Bryll, A.R, Zhu, J, Feldman, J.L, Peterson, C.L, Tan, S, Armache, J.-P. | | 登録日 | 2023-02-11 | | 公開日 | 2023-04-26 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | Cryo-EM structure of the human Sirtuin 6-nucleosome complex.
Sci Adv, 9, 2023
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8F86
 | | SIRT6 bound to an H3K9Ac nucleosome | | 分子名称: | DNA (148-MER), Histone H2A type 1, Histone H2B, ... | | 著者 | Markert, J, Whedon, S, Wang, Z, Cole, P, Farnung, L. | | 登録日 | 2022-11-21 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation.
J.Am.Chem.Soc., 145, 2023
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7CL1
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