7CL0

Crystal structure of human SIRT6

Summary for 7CL0

• Entry DOI: 10.2210/pdb7cl0/pdb
• Descriptor: NAD-dependent protein deacetylase sirtuin-6, THR-ALA-ARG-LYS-SER-THR-GLY, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ... (9 entities in total)
• Functional Keywords: deacylase, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 42312.23

Authors

Song, K.,Zhang, J. (deposition date: 2020-07-20, release date: 2021-02-24, Last modification date: 2023-11-29)

• Primary citation: Huang, Z.,Zhao, J.,Deng, W.,Chen, Y.,Shang, J.,Song, K.,Zhang, L.,Wang, C.,Lu, S.,Yang, X.,He, B.,Min, J.,Hu, H.,Tan, M.,Xu, J.,Zhang, Q.,Zhong, J.,Sun, X.,Mao, Z.,Lin, H.,Xiao, M.,Chin, Y.E.,Jiang, H.,Shen, H.,Xu, Y.,Chen, G.,Zhang, J.; Reply to: Binding site for MDL-801 on SIRT6.; Nat.Chem.Biol., 17:522-523, 2021; PubMed: 33649600; DOI: 10.1038/s41589-021-00750-5

Experimental method

X-RAY DIFFRACTION (2.53 Å)