6ZU4

Human Sirt6 13-308 in complex with ADP-ribose and the activator fluvastatin

Summary for 6ZU4

• Entry DOI: 10.2210/pdb6zu4/pdb
• Descriptor: NAD-dependent protein deacetylase sirtuin-6, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ZINC ION, ... (7 entities in total)
• Functional Keywords: deacylase, activator, allosteric, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 69972.86

Authors

You, W.,Steegborn, C. (deposition date: 2020-07-21, release date: 2020-11-18, Last modification date: 2024-01-31)

• Primary citation: You, W.,Steegborn, C.; Structural Basis for Activation of Human Sirtuin 6 by Fluvastatin.; Acs Med.Chem.Lett., 11:2285-2289, 2020; PubMed: 33214841; DOI: 10.1021/acsmedchemlett.0c00407

Experimental method

X-RAY DIFFRACTION (2.46 Å)