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PDB: 54 件
8SHK
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BU of 8shk by Molmil
Structure of binary complex of mouse cGAS and bound ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, ZINC ION
著者Wu, S, Sohn, J.
登録日2023-04-14
公開日2024-04-24
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS.
Nat Commun, 15, 2024
8SHU
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BU of 8shu by Molmil
Structure of mouse cGAS
分子名称: Cyclic GMP-AMP synthase, ZINC ION
著者Wu, S, Sohn, J.
登録日2023-04-14
公開日2024-04-24
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS.
Nat Commun, 15, 2024
8SHY
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BU of 8shy by Molmil
Structure of binary complex of mouse cGAS QN and bound ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, ZINC ION
著者Wu, S, Sohn, J.
登録日2023-04-14
公開日2024-04-24
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS.
Nat Commun, 15, 2024
5XZG
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BU of 5xzg by Molmil
Mouse cGAS bound to the inhibitor RU521
分子名称: 2-(4,5-dichloro-1H-benzimidazol-2-yl)-5-methyl-4-[(1R)-3-oxo-1,3-dihydro-2-benzofuran-1-yl]-1,2-dihydro-3H-pyrazol-3-one, Cyclic GMP-AMP synthase, DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*G)-3'), ...
著者Vincent, J, Adura, C, Gao, P, Luz, A, Lama, L, Asano, Y, Okamoto, R, Imaeda, T, Aida, J, Rothamel, K, Gogakos, T, Steinberg, J, Reasoner, S, Aso, K, Tuschl, T, Patel, D.J, Glickman, J.F, Ascano, M.
登録日2017-07-12
公開日2017-10-11
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.828 Å)
主引用文献Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Nat Commun, 8, 2017
4O6A
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BU of 4o6a by Molmil
Mouse cyclic GMP-AMP synthase (cGAS) in complex with DNA
分子名称: Cyclic GMP-AMP synthase, DNA1, DNA2, ...
著者Zhang, X, Chen, Z, Zhang, X.W, Chen, Z.J.
登録日2013-12-20
公開日2014-02-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.859 Å)
主引用文献The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
Cell Rep, 6, 2014
4K98
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BU of 4k98 by Molmil
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG
分子名称: Cyclic GMP-AMP synthase, DNA-F, DNA-R, ...
著者Gao, P, Wu, Y, Patel, D.J.
登録日2013-04-19
公開日2013-05-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Cell(Cambridge,Mass.), 153, 2013
4K99
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BU of 4k99 by Molmil
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppdG(2 ,5 )pdG
分子名称: 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE, 3'-deoxy-guanosine 5'-monophosphate, Cyclic GMP-AMP synthase, ...
著者Gao, P, Wu, Y, Patel, D.J.
登録日2013-04-19
公開日2013-05-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Cell(Cambridge,Mass.), 153, 2013
4K8V
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BU of 4k8v by Molmil
Structure of cyclic GMP-AMP Synthase (cGAS)
分子名称: Cyclic GMP-AMP synthase, ZINC ION
著者Gao, P, Wu, Y, Patel, D.J.
登録日2013-04-18
公開日2013-05-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Cell(Cambridge,Mass.), 153, 2013
7UTT
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BU of 7utt by Molmil
Structure of Non-hydrolyzable ATP (ApCpp) binds to Cyclic GMP AMP synthase (cGAS) through Mn coordination
分子名称: Cyclic GMP-AMP synthase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, MANGANESE (II) ION, ...
著者Wu, S, Gabelli, S.B, Sohn, J.
登録日2022-04-27
公開日2023-05-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Structure of Non-hydrolyzable ATP (ApCpp) binds to Cyclic GMP AMP synthase (cGAS) through Mn coordination
To Be Published
4K96
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BU of 4k96 by Molmil
Structure of Binary Complex of cGAS with Bound dsDNA
分子名称: Cyclic GMP-AMP synthase, DNA-F, DNA-R, ...
著者Gao, P, Wu, Y, Patel, D.J.
登録日2013-04-19
公開日2013-05-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.084 Å)
主引用文献Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Cell(Cambridge,Mass.), 153, 2013
5XZB
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BU of 5xzb by Molmil
Mouse cGAS bound to the inhibitor RU365
分子名称: (3R)-3-[1-(1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-2-benzofuran-1(3H)-one, Cyclic GMP-AMP synthase, DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*G)-3'), ...
著者Vincent, J, Adura, C, Gao, P, Luz, A, Lama, L, Asano, Y, Okamoto, R, Imaeda, T, Aida, J, Rothamel, K, Gogakos, T, Steinberg, J, Reasoner, S, Aso, K, Tuschl, T, Patel, D.J, Glickman, J.F, Ascano, M.
登録日2017-07-12
公開日2017-08-09
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Nat Commun, 8, 2017
7BUJ
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BU of 7buj by Molmil
mcGAS bound with pppGpG
分子名称: Cyclic GMP-AMP synthase, GUANOSINE-5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Wang, B, Su, X.D.
登録日2020-04-07
公開日2020-09-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Mn2+Directly Activates cGAS and Structural Analysis Suggests Mn2+Induces a Noncanonical Catalytic Synthesis of 2'3'-cGAMP.
Cell Rep, 32, 2020
5XZE
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BU of 5xze by Molmil
Mouse cGAS bound to the inhibitor RU332
分子名称: (3R)-3-[1-(3H-1lambda~4~,3-benzothiazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-2-benzofuran-1(3H)-one, Cyclic GMP-AMP synthase, DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*G)-3'), ...
著者Vincent, J, Adura, C, Gao, P, Luz, A, Lama, L, Asano, Y, Okamoto, R, Imaeda, T, Aida, J, Rothamel, K, Gogakos, T, Steinberg, J, Reasoner, S, Aso, K, Tuschl, T, Patel, D.J, Glickman, J.F, Ascano, M.
登録日2017-07-12
公開日2017-10-11
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.177 Å)
主引用文献Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Nat Commun, 8, 2017
8SJ2
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BU of 8sj2 by Molmil
Structure of ternary complex of cGAS with dsDNA and bound ATP and 2'-dGTP
分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, ...
著者Wu, S, Sohn, J.
登録日2023-04-17
公開日2024-04-24
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS.
Nat Commun, 15, 2024
4K9B
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BU of 4k9b by Molmil
Structure of Ternary Complex of cGAS with dsDNA and Bound c[G(2 ,5 )pA(3 ,5 )p]
分子名称: ADENOSINE MONOPHOSPHATE, Cyclic GMP-AMP synthase, DNA-F, ...
著者Gao, P, Wu, Y, Patel, D.J.
登録日2013-04-19
公開日2013-05-15
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Cell(Cambridge,Mass.), 153, 2013
7UUX
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BU of 7uux by Molmil
ATP binds to Cyclic GMP AMP synthase (cGAS) through Mg coordination
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, MAGNESIUM ION, ...
著者Wu, S, Gabelli, S.B, Sohn, J.
登録日2022-04-29
公開日2023-05-03
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS
Nat Commun, 15, 2024
4K9A
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BU of 4k9a by Molmil
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pG(2 ,5 )pA
分子名称: ADENOSINE MONOPHOSPHATE, Cyclic GMP-AMP synthase, DNA-F, ...
著者Gao, P, Wu, Y, Patel, D.J.
登録日2013-04-19
公開日2013-05-15
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.264 Å)
主引用文献Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Cell(Cambridge,Mass.), 153, 2013
8G1J
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BU of 8g1j by Molmil
Structure of Ternary Complex of cGAS with dsDNA and Bound ATP and ITP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Wu, S, Sohn, J.
登録日2023-02-02
公開日2024-05-22
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS.
Nat Commun, 15, 2024
4LEZ
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BU of 4lez by Molmil
Structure of mouse cGAS bound to an 18bp DNA and cGAS product
分子名称: 18bp dsDNA, Cyclic GMP-AMP synthase, ZINC ION, ...
著者Li, P.
登録日2013-06-26
公開日2013-12-25
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization.
Immunity, 39, 2013
8G2Q
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BU of 8g2q by Molmil
Structure of Ternary Complex of mouse cGAS with dsDNA and Bound GTP
分子名称: Cyclic GMP-AMP synthase, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Wu, S, Sohn, J.
登録日2023-02-06
公開日2024-06-19
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Structure of Ternary Complex of mouse cGAS with dsDNA and Bound GTP
To Be Published
4K97
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BU of 4k97 by Molmil
Structure of Ternary Complex of cGAS with dsDNA and Bound ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, DNA-F, ...
著者Gao, P, Wu, Y, Patel, D.J.
登録日2013-04-19
公開日2013-05-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Cell(Cambridge,Mass.), 153, 2013
8ECC
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BU of 8ecc by Molmil
Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppI(2,5)pA
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, MAGNESIUM ION, ...
著者Wu, S, Sohn, J.
登録日2022-09-01
公開日2024-01-17
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppI(2,5)pA
To Be Published
8GIS
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BU of 8gis by Molmil
Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ and 0.5mM Mn2+
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, MANGANESE (II) ION, ...
著者Wu, S, Sohn, J.
登録日2023-03-14
公開日2024-04-17
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS.
Nat Commun, 15, 2024
8G10
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BU of 8g10 by Molmil
Structure of Ternary Complex of cGAS with dsDNA and Bound ITP and GTP
分子名称: Cyclic GMP-AMP synthase, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Wu, S, Sohn, J.
登録日2023-02-01
公開日2024-05-22
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS.
Nat Commun, 15, 2024
7UYZ
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BU of 7uyz by Molmil
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG
分子名称: Cyclic GMP-AMP synthase, GUANOSINE-5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Wu, S, Gabelli, S.B, Sohn, J.
登録日2022-05-07
公開日2023-05-10
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS
Nat Commun, 15, 2024

 

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