5V8P
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4KTX
| Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A C134S mutant with covalent inhibitor that modifies Cys-165 causing disorder in 167-174 stretch | 分子名称: | Botulinum neurotoxin A light chain, GLYCEROL, Peptide inhibitor MPT-DPP-ARG-G-LEU-NH2, ... | 著者 | Stura, E.A, Vera, L, Guitot, K, Dive, V. | 登録日 | 2013-05-21 | 公開日 | 2014-10-15 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Covalent modification of the active site cysteine stresses Clostridium botulinum neurotoxin A To be Published
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2W2D
| Crystal Structure of a Catalytically Active, Non-toxic Endopeptidase Derivative of Clostridium botulinum Toxin A | 分子名称: | ACETATE ION, BOTULINUM NEUROTOXIN A HEAVY CHAIN, BOTULINUM NEUROTOXIN A LIGHT CHAIN, ... | 著者 | Masuyer, G, Thiyagarajan, N, James, P.L, Marks, P.M.H, Chaddock, J.A, Acharya, K.R. | 登録日 | 2008-10-29 | 公開日 | 2009-03-24 | 最終更新日 | 2022-05-04 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Crystal Structure of a Catalytically Active, Non-Toxic Endopeptidase Derivative of Clostridium Botulinum Toxin A. Biochem.Biophys.Res.Commun., 381, 2009
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5TPB
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3K3Q
| Crystal Structure of a Llama Antibody complexed with the C. Botulinum Neurotoxin Serotype A Catalytic Domain | 分子名称: | Botulinum neurotoxin type A, ZINC ION, llama Aa1 VHH domain | 著者 | Thompson, A.A, Dong, J, Marks, J.D, Stevens, R.C. | 登録日 | 2009-10-04 | 公開日 | 2010-02-23 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic alpha-Exosite Binding Region. J.Mol.Biol., 397, 2010
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5VGV
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2NYY
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5JMC
| Receptor binding domain of Botulinum neurotoxin A in complex with rat SV2C | 分子名称: | Botulinum neurotoxin type A, Synaptic vesicle glycoprotein 2C | 著者 | Yao, G, Zhang, S, Mahrhold, S, Lam, K, Stern, D, Bagramyan, K, Perry, K, Kalkum, M, Rummel, A, Dong, M, Jin, R. | 登録日 | 2016-04-28 | 公開日 | 2016-06-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nat.Struct.Mol.Biol., 23, 2016
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8HKH
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3V0A
| 2.7 angstrom crystal structure of BoNT/Ai in complex with NTNHA | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BoNT/A, CALCIUM ION, ... | 著者 | Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R. | 登録日 | 2011-12-07 | 公開日 | 2012-03-14 | 実験手法 | X-RAY DIFFRACTION (2.703 Å) | 主引用文献 | Botulinum neurotoxin is shielded by NTNHA in an interlocked complex. Science, 335, 2012
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3ZUR
| Crystal structure of an engineered botulinum neurotoxin type A- SNARE23 derivative, LC0-A-SNAP25-Hn-A | 分子名称: | BOTULINUM NEUROTOXIN TYPE A, SYNAPTOSOMAL-ASSOCIATED PROTEIN, SULFATE ION | 著者 | Masuyer, G, Stancombe, P, Chaddock, J.A, Acharya, K.R. | 登録日 | 2011-07-19 | 公開日 | 2011-12-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Structures of Engineered Clostridium Botulinum Neurotoxin Derivatives Acta Crystallogr.,Sect.F, 67, 2011
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7KY2
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7M1H
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7LZP
| LC/A-JPU-B9-JPU-A11-JPU-G11 | 分子名称: | Botulinum neurotoxin A light chain, JPU-A11, JPU-B9, ... | 著者 | Lam, K, Jin, R. | 登録日 | 2021-03-10 | 公開日 | 2021-12-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies. Plos Pathog., 18, 2022
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3ZUS
| Crystal structure of an engineered botulinum neurotoxin type A- SNARE23 derivative, LC-A-SNAP23-Hn-A | 分子名称: | BOTULINUM NEUROTOXIN TYPE A, SYNAPTOSOMAL-ASSOCIATED PROTEIN 23, ZINC ION | 著者 | Masuyer, G, Stancombe, P, Chaddock, J.A, Acharya, K.R. | 登録日 | 2011-07-19 | 公開日 | 2011-12-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structures of Engineered Clostridium Botulinum Neurotoxin Derivatives Acta Crystallogr.,Sect.F, 67, 2011
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3BTA
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2NZ9
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3V0B
| 3.9 angstrom crystal structure of BoNT/Ai in complex with NTNHA | 分子名称: | BoNT/A, CALCIUM ION, NTNH, ... | 著者 | Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R. | 登録日 | 2011-12-07 | 公開日 | 2012-03-14 | 最終更新日 | 2013-09-25 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Botulinum neurotoxin is shielded by NTNHA in an interlocked complex. Science, 335, 2012
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3V0C
| 4.3 angstrom crystal structure of an inactive BoNT/A (E224Q/R363A/Y366F) | 分子名称: | BoNT/A, ZINC ION | 著者 | Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R. | 登録日 | 2011-12-07 | 公開日 | 2012-03-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | 主引用文献 | Botulinum neurotoxin is shielded by NTNHA in an interlocked complex. Science, 335, 2012
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