2W2D

Crystal Structure of a Catalytically Active, Non-toxic Endopeptidase Derivative of Clostridium botulinum Toxin A

Summary for 2W2D

Entry DOI	10.2210/pdb2w2d/pdb
Descriptor	BOTULINUM NEUROTOXIN A LIGHT CHAIN, BOTULINUM NEUROTOXIN A HEAVY CHAIN, SULFATE ION, ... (8 entities in total)
Functional Keywords	metalloprotease, membrane domain, protein engineering, neurotoxin, metal-binding, transmembrane, pharmaceutical, hydrolase, zinc protease, mixed alpha and beta, bont, membrane, secreted, protease
Biological source	CLOSTRIDIUM BOTULINUM More
Cellular location	Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9
Total number of polymer chains	4
Total formula weight	203251.05
Authors	Masuyer, G.,Thiyagarajan, N.,James, P.L.,Marks, P.M.H.,Chaddock, J.A.,Acharya, K.R. (deposition date: 2008-10-29, release date: 2009-03-24, Last modification date: 2022-05-04)
Primary citation	Masuyer, G.,Thiyagarajan, N.,James, P.L.,Marks, P.M.H.,Chaddock, J.A.,Acharya, K.R. Crystal Structure of a Catalytically Active, Non-Toxic Endopeptidase Derivative of Clostridium Botulinum Toxin A. Biochem.Biophys.Res.Commun., 381:50-, 2009 Cited by PubMed: 19351593 DOI: 10.1016/J.BBRC.2009.02.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.59 Å)

Structure validation