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PDB: 65 件
7RE8
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BU of 7re8 by Molmil
Class I MHC (HLA-A*02) presenting alpha fetoprotein peptide (AFP)
分子名称: Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, MHC class I antigen, ...
著者Dasgupta, M, Baker, B.M.
登録日2021-07-12
公開日2022-07-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Validation and promise of a TCR mimic antibody for cancer immunotherapy of hepatocellular carcinoma.
Sci Rep, 12, 2022
6VMC
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BU of 6vmc by Molmil
T4H2 T cell receptor bound to HLA-A2 presenting gp100T2L peptide (ILDQVPFSV)
分子名称: Beta-2-microglobulin, GLYCEROL, MHC class I antigen, ...
著者Smith, A.R, Baker, B.M.
登録日2020-01-27
公開日2021-01-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Structurally silent peptide anchor modifications allosterically modulate T cell recognition in a receptor-dependent manner
Proc.Natl.Acad.Sci.USA, 118, 2021
8U9G
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Human Class I MHC HLA-A2 bound to sorting nexin 24 (127-135) neoantigen KLSHQLVLL
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ...
著者Arbuiso, A, Weiss, L.I, Brambley, C.A, Ma, J, Keller, G.L.J, Ayres, C.M, Baker, B.M.
登録日2023-09-19
公開日2024-01-10
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献Accurate modeling of peptide-MHC structures with AlphaFold.
Structure, 32, 2024
8EB2
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Structure of HLA-A*02:01 in complex with NY-ESO-1 peptide and PA2.1 Fab
分子名称: Beta-2-microglobulin, HLA-A*02:01 alpha chain, NY-ESO-1 peptide, ...
著者Jette, C.A, West, A.P.
登録日2022-08-30
公開日2022-11-30
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献HLA-A∗02-gated safety switch for cancer therapy has exquisite specificity for its allelic target antigen.
Mol Ther Oncolytics, 27, 2022
6VM9
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BU of 6vm9 by Molmil
T4H2 T cell receptor bound to HLA-A2 presenting gp100T2M peptide (IMDQVPFSV)
分子名称: Beta-2-microglobulin, MHC class I antigen, A-2 alpha chain, ...
著者Smith, A.R, Baker, B.M.
登録日2020-01-27
公開日2021-01-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structurally silent peptide anchor modifications allosterically modulate T cell recognition in a receptor-dependent manner
Proc.Natl.Acad.Sci.USA, 118, 2021
6VQO
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BU of 6vqo by Molmil
T cell receptor-p53-HLA-A2 complex
分子名称: Beta-2-microglobulin, MHC class I antigen, T-cell receptor 1a2, ...
著者Wu, D, Gallagher, D.T, Pierce, B.G, Mariuzza, R.A.
登録日2020-02-05
公開日2020-06-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen.
Nat Commun, 11, 2020
7PBE
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BU of 7pbe by Molmil
Emergence of immune escape at dominant SARS-CoV-2 killer T-cell epitope
分子名称: Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, Human T-cell Receptor YLQ36, ...
著者Rizkallah, P.J, Sewell, A.K, Wall, A, Fuller, A.
登録日2021-08-02
公開日2022-04-27
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope.
Cell, 185, 2022
6TRO
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BU of 6tro by Molmil
Crystal structure of the T-cell receptor GVY01 bound to HLA A2*01-GVYDGREHTV
分子名称: Beta-2-microglobulin, MAGE-A4 peptide (amino acids 230-239), MHC class I antigen, ...
著者Coles, C.H, McMurran, C, Lloyd, A, Hibbert, L, Lupardus, P.J, Cole, D.K, Harper, S.
登録日2019-12-19
公開日2020-06-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4.
J.Biol.Chem., 295, 2020
6P64
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Alpha-beta TCR Binding to Neoantigen KQWLVWLFL Presented by HLA-A206
分子名称: 302TIL TCR alpha chain, 302TIL TCR beta chain, Beta-2-microglobulin, ...
著者Devlin, J.R, Baker, B.M.
登録日2019-05-31
公開日2020-06-03
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献A T cell receptor peptide/MHC complex at 3.05 Angstrom resolution
To be Published
8ESB
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CryoEM structure of HLA-A2 bound to MAGEA8 (232-241) peptide
分子名称: Beta-2-microglobulin,HLA class I antigen,MAGE-A8 peptide chimera
著者Saotome, K, Franklin, M.C.
登録日2022-10-13
公開日2023-05-03
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM.
Nat Commun, 14, 2023
6UZ1
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BU of 6uz1 by Molmil
Noncanonical binding of single-chain A6 TCR variant S3-4 in complex with Tax/HLA-A2
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-2-microglobulin, LEU-LEU-PHE-GLY-TYR-PRO-VAL-TYR-VAL, ...
著者Ma, J, Singh, N.K.
登録日2019-11-14
公開日2020-10-28
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.14 Å)
主引用文献An Engineered T Cell Receptor Variant Realizes the Limits of Functional Binding Modes.
Biochemistry, 59, 2020
7N6E
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BU of 7n6e by Molmil
TCR peptide HLA-A2 complex
分子名称: Beta-2-microglobulin, MHC class I antigen, Spike protein S1, ...
著者Chaurasia, P, Rossjohn, J, Petersen, J.
登録日2021-06-08
公開日2021-07-28
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein.
J.Biol.Chem., 297, 2021
7Q9B
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BU of 7q9b by Molmil
MHC Class I A02 Allele presenting EAAGIGILTV, in complex with Mel8 TCR
分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, GLU-ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL, ...
著者Rizkallah, P.J, Sewell, A.K, Wall, A, Fuller, A.
登録日2021-11-12
公開日2023-02-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.24 Å)
主引用文献Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy.
Cell, 186, 2023
8ESA
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BU of 8esa by Molmil
CryoEM structure of HLA-A2 bound to MAGEA4 (230-239) peptide
分子名称: Beta-2-microglobulin,HLA class I antigen,MAGE-A4 peptide chimera
著者Saotome, K, Franklin, M.C.
登録日2022-10-13
公開日2023-05-03
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM.
Nat Commun, 14, 2023
6W51
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BU of 6w51 by Molmil
Structure of the antibody fragment H2 in complex with HLA-A*02:01/p53R175H
分子名称: Beta-2-microglobulin, Cellular tumor antigen p53 peptide, Immunoglobulin heavy chain H2, ...
著者Wright, K.M, Gabelli, S.B.
登録日2020-03-12
公開日2021-03-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.53 Å)
主引用文献Targeting a neoantigen derived from a common TP53 mutation.
Science, 371, 2021
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件を2024-09-04に公開中

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