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PDB: 50 件
9BON
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BU of 9bon by Molmil
Crystal structure of glucosyltransferase (GTD) domain of TpeL
分子名称: TpeL
著者Gill, S, Sugiman-Marangos, S.N, Beilhartz, G.L, Mei, E, Taipale, M, Melnyk, R.A.
登録日2024-05-05
公開日2024-08-07
実験手法X-RAY DIFFRACTION (2.222 Å)
主引用文献A diphtheria toxin-like intracellular delivery platform that evades pre-existing antidrug antibodies.
Embo Mol Med, 2024
3SS1
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BU of 3ss1 by Molmil
Clostridium difficile toxin A (TcdA) glucolsyltransferase domain
分子名称: MANGANESE (II) ION, Toxin A
著者Pruitt, R.N, Chumbler, N.M, Farrow, M.A, Seeback, S.A, Friedman, D.B, Spiller, B.W, Lacy, D.B.
登録日2011-07-07
公開日2012-02-01
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.202 Å)
主引用文献Structural Determinants of Clostridium difficile Toxin A Glucosyltransferase Activity.
J.Biol.Chem., 287, 2012
4DMV
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BU of 4dmv by Molmil
Crystal structure of the GT domain of Clostridium difficile Toxin A
分子名称: Toxin A
著者Malito, E, D'Urzo, N, Bottomley, M.J, Biancucci, M, Maione, D, Scarselli, M, Martinelli, M.
登録日2012-02-08
公開日2012-07-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The structure of Clostridium difficile toxin A glucosyltransferase domain bound to Mn2+ and UDP provides insights into glucosyltransferase activity and product release.
Febs J., 279, 2012
7UBY
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BU of 7uby by Molmil
Structure of the GTD domain of Clostridium difficile toxin A in complex with VHH AH3
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Glucosyltransferase TcdA, ...
著者Chen, B, Rongsheng, J, Kay, P.
登録日2022-03-15
公開日2022-11-16
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies.
Front Immunol, 13, 2022
4DMW
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BU of 4dmw by Molmil
Crystal structure of the GT domain of Clostridium difficile toxin A (TcdA) in complex with UDP and Manganese
分子名称: MANGANESE (II) ION, Toxin A, URIDINE-5'-DIPHOSPHATE
著者Malito, E, D'Urzo, N, Bottomley, M.J, Biancucci, M, Scarselli, M, Maione, D, Martinelli, M.
登録日2012-02-08
公開日2012-07-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The structure of Clostridium difficile toxin A glucosyltransferase domain bound to Mn2+ and UDP provides insights into glucosyltransferase activity and product release.
Febs J., 279, 2012
3SRZ
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BU of 3srz by Molmil
Clostridium difficile toxin A (TcdA) glucolsyltransferase domain bound to UDP-glucose
分子名称: MANGANESE (II) ION, Toxin A, URIDINE-5'-DIPHOSPHATE-GLUCOSE
著者Pruitt, R.N, Chumbler, N.M, Farrow, M.A, Seeback, S.A, Friedman, D.B, Spiller, B.W, Lacy, D.B.
登録日2011-07-07
公開日2012-02-01
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Structural Determinants of Clostridium difficile Toxin A Glucosyltransferase Activity.
J.Biol.Chem., 287, 2012
6OQ8
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BU of 6oq8 by Molmil
Structure of the GTD domain of Clostridium difficile toxin B in complex with VHH 7F
分子名称: 7F, Toxin B
著者Chen, P, Lam, K, Jin, R.
登録日2019-04-25
公開日2019-07-10
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of the full-length Clostridium difficile toxin B.
Nat.Struct.Mol.Biol., 26, 2019
2BVM
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Crystal structure of the catalytic domain of toxin B from Clostridium difficile in complex with UDP, Glc and manganese ion
分子名称: MANGANESE (II) ION, SULFATE ION, TOXIN B, ...
著者Reinert, D.J, Jank, T, Aktories, K, Schulz, G.E.
登録日2005-06-30
公開日2005-08-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structural Basis for the Function of Clostridium Difficile Toxin B.
J.Mol.Biol., 351, 2005
2BVL
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BU of 2bvl by Molmil
Crystal structure of the catalytic domain of toxin B from Clostridium difficile in complex with UDP, Glc and manganese ion
分子名称: HEXATANTALUM DODECABROMIDE, MANGANESE (II) ION, SULFATE ION, ...
著者Reinert, D.J, Jank, T, Aktories, K, Schulz, G.E.
登録日2005-06-30
公開日2005-08-03
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Basis for the Function of Clostridium Difficile Toxin B.
J.Mol.Biol., 351, 2005
2VK9
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BU of 2vk9 by Molmil
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF ALPHA-TOXIN FROM CLOSTRIDIUM NOVYI
分子名称: ALPHA-TOXIN
著者Ziegler, M.O.P, Jank, T, Aktories, K, Schulz, G.E.
登録日2007-12-18
公開日2008-03-18
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Conformational Changes and Reaction of Clostridial Glycosylating Toxins.
J.Mol.Biol., 377, 2008
7SO7
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BU of 7so7 by Molmil
Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B
分子名称: FAB B1 LC, Fab B1 HC, Toxin B
著者Liu, J.
登録日2021-10-29
公開日2022-05-11
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (3.59 Å)
主引用文献Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B.
Curr Res Struct Biol, 4, 2022
7SO5
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Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B
分子名称: Fab B2 HC, Fab B2 LC, Toxin B
著者Liu, J.
登録日2021-10-29
公開日2022-05-11
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (1.797 Å)
主引用文献Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B.
Curr Res Struct Biol, 4, 2022
8Y2L
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BU of 8y2l by Molmil
The Crystal Structure of Glucosyltransferase TcdB from Clostridioides difficile
分子名称: Glucosyltransferase TcdB, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE
著者Fan, S, Wei, X, Lv, R, Wang, C, Tang, M, Jin, Y, Yang, Z.
登録日2024-01-26
公開日2025-01-29
実験手法X-RAY DIFFRACTION (3.95 Å)
主引用文献The Crystal Structure of Glucosyltransferase TcdB from Clostridioides difficile
To Be Published
5UQK
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Clostridium difficile toxin A (TcdA) glucosyltransferase domain in complex with U2F
分子名称: MANGANESE (II) ION, Toxin A, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE
著者Alvin, J.W, Lacy, D.B.
登録日2017-02-08
公開日2017-05-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.851 Å)
主引用文献Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
5UQL
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Clostridium difficile toxin A (TcdA) glucosyltransferase domain in complex with U2F
分子名称: MANGANESE (II) ION, Toxin A, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE
著者Alvin, J.W, Lacy, D.B.
登録日2017-02-08
公開日2017-05-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
5UQT
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Clostridium difficile Toxin B (TcdB) glucosyltransferase domain co-crystallized with apigenin
分子名称: 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, MANGANESE (II) ION, Toxin B
著者Alvin, J.W, Lacy, D.B.
登録日2017-02-08
公開日2017-05-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
5UQM
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Clostridium difficile Toxin B (TcdB) glucosyltransferase domain in complex with U2F
分子名称: MANGANESE (II) ION, SULFATE ION, Toxin B, ...
著者Alvin, J.W, Lacy, D.B.
登録日2017-02-08
公開日2017-05-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
5UQN
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BU of 5uqn by Molmil
Clostridium difficile Toxin B (TcdB) glucosyltransferase domain in complex with U2F
分子名称: MANGANESE (II) ION, SULFATE ION, Toxin B, ...
著者Alvin, J.W, Lacy, D.B.
登録日2017-02-08
公開日2017-05-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
7LOU
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Crystal structure of Clostridium difficile Toxin B (TcdB) glucosyltransferase in complex with UDP and isofagomine
分子名称: 1,2-ETHANEDIOL, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, Glucosyltransferase TcdB, ...
著者Harijan, R.K, Paparella, A.S, Aboulache, B.L, Bonanno, J.B, Almo, S.C, Schramm, V.L.
登録日2021-02-10
公開日2021-11-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues.
Nat Commun, 12, 2021
7LOV
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Crystal structure of Clostridium difficile Toxin B (TcdB) glucosyltransferase in complex with UDP and noeuromycin
分子名称: (2R,3S,4R,5R)-5-(HYDROXYMETHYL)PIPERIDINE-2,3,4-TRIOL, GLYCEROL, MANGANESE (II) ION, ...
著者Harijan, R.K, Paparella, A.S, Aboulache, B.L, Bonanno, J.B, Almo, S.C, Schramm, V.L.
登録日2021-02-10
公開日2021-11-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues.
Nat Commun, 12, 2021
7POG
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High-resolution structure of native toxin A from Clostridioides difficile
分子名称: Toxin A, ZINC ION
著者Boesen, T, Joergensen, R, Aminzadeh, A, Engelbrecht Larsen, C.
登録日2021-09-08
公開日2021-12-08
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献High-resolution structure of native toxin A from Clostridioides difficile.
Embo Rep., 23, 2022
9CM5
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BU of 9cm5 by Molmil
CryoEM Strucuture of TcdB in complex with De Novo Minibinder fzd48
分子名称: De Novo Minibinder fzd48, Toxin B
著者Weidle, C, Carr, K.D, Borst, A.J.
登録日2024-07-12
公開日2025-05-21
実験手法ELECTRON MICROSCOPY (4.61 Å)
主引用文献De Novo Design of Potent Inhibitors of Clostridial Family Toxins
To Be Published
6AR6
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Clostridioides difficile toxinB with DLD-4 darpin
分子名称: DLD-4 darpin, Toxin B
著者Zhang, J, Jiang, M.
登録日2017-08-21
公開日2018-08-22
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (9 Å)
主引用文献Clostridioides difficile toxinB with DLD-4 darpin
To Be Published
6OQ5
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Structure of the full-length Clostridium difficile toxin B in complex with 3 VHHs
分子名称: 5D, 7F, E3, ...
著者Chen, P, Lam, K, Jin, R.
登録日2019-04-25
公開日2019-07-10
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (3.87 Å)
主引用文献Structure of the full-length Clostridium difficile toxin B.
Nat.Struct.Mol.Biol., 26, 2019
4R04
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BU of 4r04 by Molmil
Clostridium difficile Toxin A (TcdA)
分子名称: Toxin A, ZINC ION
著者Lacy, D.B, Spiller, B.W, Rutherford, S.A.
登録日2014-07-29
公開日2016-01-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.26 Å)
主引用文献Glucosyl Transferase Structure
Nat Microbiol, 2016

 

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