6VWA
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8STE
| Cryo-EM structure of NKCC1 Fu_CTD | 分子名称: | 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, Solute carrier family 12 member 2 | 著者 | Moseng, M.A. | 登録日 | 2023-05-10 | 公開日 | 2023-05-17 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling. Sci Adv, 8, 2022
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6VW9
| C-terminal regulatory domain of the chloride transporter KCC-1 from C. elegans, proteolyzed during crystallization | 分子名称: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, GLYCEROL, K+/Cl-Cotransporter | 著者 | Zimanyi, C.M, Cheung, J. | 登録日 | 2020-02-19 | 公開日 | 2020-07-15 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure of the Regulatory Cytosolic Domain of a Eukaryotic Potassium-Chloride Cotransporter. Structure, 28, 2020
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6NPJ
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9BWT
| human sodium chloride cotransporter NCC S344E in the phosphorylation state and in complex with hydrochlorothiazide | 分子名称: | 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, ADENOSINE-5'-TRIPHOSPHATE, Solute carrier family 12 member 3 | 著者 | Cao, E.H, Zhao, Y.X. | 登録日 | 2024-05-21 | 公開日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases. Nat Commun, 15, 2024
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6Y5R
| Structure of Human Potassium Chloride Transporter KCC3 S45D/T940D/T997D in NaCl | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier family 12 member 6, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Chi, G, Man, H, Ebenhoch, R, Reggiano, G, Pike, A.C.W, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, B, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Singh, N.K, Abrusci, P, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, DiMaio, F, Duerr, K.L, Structural Genomics Consortium (SGC) | 登録日 | 2020-02-25 | 公開日 | 2020-03-11 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.76 Å) | 主引用文献 | Structure of Human Potassium Chloride Transporter KCC3 in NaCl To be published
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6PZT
| cryo-EM structure of human NKCC1 | 分子名称: | Solute carrier family 12 member 2 | 著者 | Cao, E, Wang, Q, Yang, X. | 登録日 | 2019-08-01 | 公開日 | 2020-03-25 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Structure of the human cation-chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy. Nat Commun, 11, 2020
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7SMP
| CryoEM structure of NKCC1 Bu-I | 分子名称: | 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, POTASSIUM ION, Solute carrier family 12 member 2 | 著者 | Moseng, M.A. | 登録日 | 2021-10-26 | 公開日 | 2022-09-28 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling. Sci Adv, 8, 2022
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6UKN
| Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs | 分子名称: | CHLORIDE ION, POTASSIUM ION, Solute carrier family 12 member 7, ... | 著者 | Reid, M.S, Kern, D.M, Brohawn, S.G. | 登録日 | 2019-10-05 | 公開日 | 2020-06-10 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.65 Å) | 主引用文献 | Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs. Elife, 9, 2020
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8VPP
| Phosphorylated human NCC in complex with chlorthalidone | 分子名称: | 2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide, Solute carrier family 12 member 3 | 著者 | Zhao, Y.X, Cao, E.H. | 登録日 | 2024-01-16 | 公開日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases. Nat Commun, 15, 2024
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6NPL
| Cryo-EM structure of NKCC1 | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHLORIDE ION, POTASSIUM ION, ... | 著者 | Feng, L, Liao, M.F, Orlando, B, Zhang, J.R. | 登録日 | 2019-01-17 | 公開日 | 2019-07-31 | 最終更新日 | 2019-08-28 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure and mechanism of the cation-chloride cotransporter NKCC1. Nature, 572, 2019
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8VPN
| Phosphorylated human NCC in complex with indapamide | 分子名称: | 4-chloro-N-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamide, ADENOSINE-5'-TRIPHOSPHATE, Solute carrier family 12 member 3 | 著者 | Zhao, Y.X, Cao, E.H. | 登録日 | 2024-01-16 | 公開日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases. Nat Commun, 15, 2024
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6Y5V
| Structure of Human Potassium Chloride Transporter KCC3b (S45D/T940D/T997D) in KCl | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier family 12 member 6, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Chi, G, Man, H, Ebenhoch, R, Reggiano, G, Pike, A.C.W, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Singh, N.K, Abrusci, P, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, DiMaio, F, Duerr, K.L. | 登録日 | 2020-02-25 | 公開日 | 2020-07-15 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (4.08 Å) | 主引用文献 | Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters. Embo J., 40, 2021
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7TTI
| Human KCC1 bound with VU0463271 In an outward-open state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-cyclopropyl-N-(4-methyl-1,3-thiazol-2-yl)-2-[(6-phenylpyridazin-3-yl)sulfanyl]acetamide, Solute carrier family 12 member 4 | 著者 | Zhao, Y.X, Cao, E.H. | 登録日 | 2022-02-01 | 公開日 | 2022-06-29 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of the human cation-chloride cotransport KCC1 in an outward-open state. Proc.Natl.Acad.Sci.USA, 119, 2022
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7TTH
| Human potassium-chloride cotransporter 1 in inward-open state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, POTASSIUM ION, Solute carrier family 12 member 4 | 著者 | Zhao, Y.X, Cao, E.H. | 登録日 | 2022-02-01 | 公開日 | 2022-06-29 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Structure of the human cation-chloride cotransport KCC1 in an outward-open state. Proc.Natl.Acad.Sci.USA, 119, 2022
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7NGB
| Structure of Wild-Type Human Potassium Chloride Transporter KCC3 in NaCl (LMNG/CHS) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Solute carrier family 12 member 6, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Chi, G, Man, H, Pike, A.C.W, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Abrusci, P, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, Duerr, K.L. | 登録日 | 2021-02-09 | 公開日 | 2021-06-09 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | 主引用文献 | Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters. Embo J., 40, 2021
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7MXO
| CryoEM structure of human NKCC1 | 分子名称: | CHLORIDE ION, POTASSIUM ION, Solute carrier family 12 member 2 | 著者 | Moseng, M.A. | 登録日 | 2021-05-19 | 公開日 | 2022-09-28 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling. Sci Adv, 8, 2022
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7N3N
| CryoEM structure of human NKCC1 state Fu-I | 分子名称: | 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, Solute carrier family 12 member 2 | 著者 | Moseng, M.A. | 登録日 | 2021-06-01 | 公開日 | 2022-09-28 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | 主引用文献 | Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling. Sci Adv, 8, 2022
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7S1X
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7S1Z
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7S1Y
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7SFL
| Human NKCC1 state Fu-II | 分子名称: | 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, Solute carrier family 12 member 2 | 著者 | Moseng, M.A. | 登録日 | 2021-10-04 | 公開日 | 2022-09-28 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling. Sci Adv, 8, 2022
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7YG1
| Cryo-EM structure of the C-terminal domain of the human sodium-chloride cotransporter | 分子名称: | Solute carrier family 12 member 3 | 著者 | Nan, J, Yang, X.M, Shan, Z.Y, Yuan, Y.F, Zhang, Y.Q. | 登録日 | 2022-07-09 | 公開日 | 2022-11-23 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.77 Å) | 主引用文献 | Cryo-EM structure of the human sodium-chloride cotransporter NCC. Sci Adv, 8, 2022
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7Y6I
| Cryo-EM structure of human sodium-chloride cotransporter | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Nan, J, Yang, X, Shan, Z, Yuan, Y, Zhang, Y.Q. | 登録日 | 2022-06-20 | 公開日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Cryo-EM structure of the human sodium-chloride cotransporter NCC. Sci Adv, 8, 2022
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7YG0
| Cryo-EM structure of human sodium-chloride cotransporter | 分子名称: | Solute carrier family 12 member 3 | 著者 | Nan, J, Yang, X.M, Shan, Z.Y, Yuan, Y.F, Zhang, Y.Q. | 登録日 | 2022-07-09 | 公開日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | 主引用文献 | Cryo-EM structure of the human sodium-chloride cotransporter NCC. Sci Adv, 8, 2022
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