6ZY6
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![BU of 6zy6 by Molmil](/molmil-images/mine/6zy6) | Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 2 | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... | 著者 | Vanden Broeck, A, Lamour, V. | 登録日 | 2020-07-30 | 公開日 | 2021-05-26 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural basis for allosteric regulation of Human Topoisomerase II alpha. Nat Commun, 12, 2021
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6ZY8
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![BU of 6zy8 by Molmil](/molmil-images/mine/6zy8) | Cryo-EM structure of the entire Human topoisomerase II alpha in State 2 | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... | 著者 | Vanden Broeck, A, Lamour, V. | 登録日 | 2020-07-30 | 公開日 | 2021-05-26 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (7.4 Å) | 主引用文献 | Structural basis for allosteric regulation of Human Topoisomerase II alpha. Nat Commun, 12, 2021
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2CH4
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6ZY5
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![BU of 6zy5 by Molmil](/molmil-images/mine/6zy5) | Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 1 | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... | 著者 | Vanden Broeck, A, Lamour, V. | 登録日 | 2020-07-30 | 公開日 | 2021-05-26 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis for allosteric regulation of Human Topoisomerase II alpha. Nat Commun, 12, 2021
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2CG9
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![BU of 2cg9 by Molmil](/molmil-images/mine/2cg9) | Crystal structure of an Hsp90-Sba1 closed chaperone complex | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, CO-CHAPERONE PROTEIN SBA1 | 著者 | Ali, M.M.U, Roe, S.M, Prodromou, C, Pearl, L.H. | 登録日 | 2006-03-01 | 公開日 | 2006-04-12 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Crystal Structure of an Hsp90-Nucleotide-P23/Sba1 Closed Chaperone Complex Nature, 440, 2006
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8SGK
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![BU of 8sgk by Molmil](/molmil-images/mine/8sgk) | CryoEM structure of Deinococcus radiodurans BphP photosensory module in Pr state | 分子名称: | 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, Bacteriophytochrome | 著者 | Li, H, Li, H. | 登録日 | 2023-04-12 | 公開日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | CryoEM structure of Deinococcus radiodurans BphP photosensory module in Pr state To Be Published
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8QQI
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![BU of 8qqi by Molmil](/molmil-images/mine/8qqi) | |
8QDX
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![BU of 8qdx by Molmil](/molmil-images/mine/8qdx) | |
8QQU
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2Q8I
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![BU of 2q8i by Molmil](/molmil-images/mine/2q8i) | Pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug radicicol | 分子名称: | DIHYDROLIPOIC ACID, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, GLYCEROL, ... | 著者 | Kato, M, Li, J, Chuang, J.L, Chuang, D.T. | 登録日 | 2007-06-10 | 公開日 | 2007-07-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol. Structure, 15, 2007
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2PNR
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![BU of 2pnr by Molmil](/molmil-images/mine/2pnr) | Crystal Structure of the asymmetric Pdk3-l2 Complex | 分子名称: | DIHYDROLIPOIC ACID, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3 | 著者 | Vassylyev, D.G, Steussy, C.N, Devedjiev, Y. | 登録日 | 2007-04-25 | 公開日 | 2007-08-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of an Asymmetric complex of Pyruvate Dehydrogenase
Kinase 3 with Lipoyl domain 2 and its Biological Implications J.Mol.Biol., 370, 2007
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8G3L
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![BU of 8g3l by Molmil](/molmil-images/mine/8g3l) | BceAB-S nucleotide free BceS state 2 | 分子名称: | Bacitracin export ATP-binding protein BceA, Bacitracin export permease protein BceB, OLEIC ACID, ... | 著者 | George, N.L, Orlando, B.J. | 登録日 | 2023-02-08 | 公開日 | 2023-06-21 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Architecture of a complete Bce-type antimicrobial peptide resistance module. Nat Commun, 14, 2023
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8G4C
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![BU of 8g4c by Molmil](/molmil-images/mine/8g4c) | BceABS ATPgS high res TM | 分子名称: | Bacitracin export ATP-binding protein BceA, Bacitracin export permease protein BceB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | George, N.L, Orlando, B.J. | 登録日 | 2023-02-09 | 公開日 | 2023-06-21 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Architecture of a complete Bce-type antimicrobial peptide resistance module. Nat Commun, 14, 2023
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8G4D
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![BU of 8g4d by Molmil](/molmil-images/mine/8g4d) | BceABS ATPgS tilted BceS | 分子名称: | Bacitracin export ATP-binding protein BceA, Bacitracin export permease protein BceB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | George, N.L, Orlando, B.J. | 登録日 | 2023-02-09 | 公開日 | 2023-06-21 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Architecture of a complete Bce-type antimicrobial peptide resistance module. Nat Commun, 14, 2023
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8G3B
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![BU of 8g3b by Molmil](/molmil-images/mine/8g3b) | BceAB-S nucleotide free TM state 2 | 分子名称: | Bacitracin export ATP-binding protein BceA, Bacitracin export permease protein BceB, OLEIC ACID, ... | 著者 | George, N.L, Orlando, B.J. | 登録日 | 2023-02-07 | 公開日 | 2023-06-21 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Architecture of a complete Bce-type antimicrobial peptide resistance module. Nat Commun, 14, 2023
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8G3F
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![BU of 8g3f by Molmil](/molmil-images/mine/8g3f) | BceAB-S nucleotide free BceS state 1 | 分子名称: | Bacitracin export ATP-binding protein BceA, Bacitracin export permease protein BceB, OLEIC ACID, ... | 著者 | George, N.L, Orlando, B.J. | 登録日 | 2023-02-07 | 公開日 | 2023-06-21 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Architecture of a complete Bce-type antimicrobial peptide resistance module. Nat Commun, 14, 2023
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8G3A
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![BU of 8g3a by Molmil](/molmil-images/mine/8g3a) | BceAB-S nucleotide free TM state 1 | 分子名称: | Bacitracin export ATP-binding protein BceA, Bacitracin export permease protein BceB, OLEIC ACID, ... | 著者 | George, N.L, Orlando, B.J. | 登録日 | 2023-02-07 | 公開日 | 2023-06-21 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Architecture of a complete Bce-type antimicrobial peptide resistance module. Nat Commun, 14, 2023
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4ZVI
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![BU of 4zvi by Molmil](/molmil-images/mine/4zvi) | GYRASE B IN COMPLEX WITH 4,5-DIBROMOPYRROLAMIDE-BASED INHIBITOR | 分子名称: | DNA gyrase subunit B, IODIDE ION, N-(4-{[(4,5-dibromo-1H-pyrrol-2-yl)carbonyl]amino}benzoyl)glycine | 著者 | Zidar, N, Macut, H, Tomasic, T, Brvar, M, Montalvao, S, Tammela, P, Solmajer, T, Peterlin Masic, L, Ilas, J, Kikelj, D. | 登録日 | 2015-05-18 | 公開日 | 2015-07-15 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | N-Phenyl-4,5-dibromopyrrolamides and N-Phenylindolamides as ATP Competitive DNA Gyrase B Inhibitors: Design, Synthesis, and Evaluation. J.Med.Chem., 58, 2015
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7Z8N
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![BU of 7z8n by Molmil](/molmil-images/mine/7z8n) | GacS histidine kinase from Pseudomonas aeruginosa | 分子名称: | CALCIUM ION, Histidine kinase, R-1,2-PROPANEDIOL | 著者 | Fadel, F, Bassim, V, Francis, V.I, Porter, S.L, Botzanowski, T, Legrand, P, Bourne, Y, Cianferani, S, Vincent, F. | 登録日 | 2022-03-17 | 公開日 | 2022-07-13 | 最終更新日 | 2023-01-25 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Insights into the atypical autokinase activity of the Pseudomonas aeruginosa GacS histidine kinase and its interaction with RetS. Structure, 30, 2022
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7Z9M
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![BU of 7z9m by Molmil](/molmil-images/mine/7z9m) | E.coli gyrase holocomplex with 217 bp DNA and Albi-1 (site AA) | 分子名称: | 4-[[4-[[5-[[(2S)-2-[[5-[(4-cyanophenyl)carbonylamino]pyridin-2-yl]carbonylamino]-3-(1H-1,2,3-triazol-4-yl)propanoyl]amino]pyridin-2-yl]carbonylamino]-2-oxidanyl-3-propan-2-yloxy-phenyl]carbonylamino]benzoic acid, DNA (5'-D(*AP*AP*TP*CP*AP*CP*CP*CP*GP*CP*AP*CP*AP*GP*AP*TP*TP*T)-3'), DNA (5'-D(*GP*AP*TP*TP*TP*TP*AP*TP*GP*CP*CP*TP*GP*AP*TP*TP*CP*T)-3'), ... | 著者 | Ghilarov, D, Heddle, J.G.H. | 登録日 | 2022-03-21 | 公開日 | 2023-02-15 | 最終更新日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin. Nat Catal, 6, 2023
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7Z9G
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![BU of 7z9g by Molmil](/molmil-images/mine/7z9g) | E.coli gyrase holocomplex with 217 bp DNA and Albi-2 | 分子名称: | 4-[[3-(2-azanylethoxy)-2-oxidanyl-4-[[5-[[(2~{S})-2-[[4-[(6-oxidanylnaphthalen-2-yl)carbonylamino]phenyl]carbonylamino]-3-(1~{H}-1,2,3-triazol-4-yl)propanoyl]amino]pyridin-2-yl]carbonylamino]phenyl]carbonylamino]-3-methoxy-2-oxidanyl-benzoic acid, DNA (5'-D(*AP*AP*TP*CP*AP*CP*CP*CP*GP*CP*AP*CP*AP*GP*AP*TP*TP*T)-3'), DNA (5'-D(*GP*AP*TP*TP*TP*TP*AP*TP*GP*CP*CP*TP*GP*AP*TP*TP*CP*T)-3'), ... | 著者 | Ghilarov, D, Heddle, J.G.H. | 登録日 | 2022-03-21 | 公開日 | 2023-02-15 | 最終更新日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin. Nat Catal, 6, 2023
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7Z9C
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![BU of 7z9c by Molmil](/molmil-images/mine/7z9c) | E.coli gyrase holocomplex with 217 bp DNA and albicidin | 分子名称: | DNA (5'-D(*AP*AP*TP*CP*AP*CP*CP*CP*GP*CP*AP*CP*AP*GP*AP*TP*TP*T)-3'), DNA (5'-D(*GP*AP*TP*TP*TP*TP*AP*TP*GP*CP*CP*TP*GP*AP*TP*TP*CP*T)-3'), DNA (5'-D(P*AP*AP*AP*TP*CP*TP*GP*TP*GP*CP*GP*GP*GP*T)-3'), ... | 著者 | Ghilarov, D, Heddle, J.G.H, Suessmuth, R. | 登録日 | 2022-03-21 | 公開日 | 2023-02-15 | 最終更新日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin. Nat Catal, 6, 2023
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7Z9K
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![BU of 7z9k by Molmil](/molmil-images/mine/7z9k) | E.coli gyrase holocomplex with 217 bp DNA and Albi-1 (site TG) | 分子名称: | 4-[[4-[[5-[[(2S)-2-[[5-[(4-cyanophenyl)carbonylamino]pyridin-2-yl]carbonylamino]-3-(1H-1,2,3-triazol-4-yl)propanoyl]amino]pyridin-2-yl]carbonylamino]-2-oxidanyl-3-propan-2-yloxy-phenyl]carbonylamino]benzoic acid, DNA (5'-D(*AP*AP*TP*CP*AP*CP*CP*CP*GP*CP*AP*CP*AP*GP*AP*TP*TP*T)-3'), DNA (5'-D(*GP*AP*TP*TP*TP*TP*AP*TP*GP*CP*CP*TP*GP*AP*TP*TP*CP*T)-3'), ... | 著者 | Ghilarov, D, Heddle, J.G.H. | 登録日 | 2022-03-21 | 公開日 | 2023-03-08 | 最終更新日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin. Nat Catal, 6, 2023
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7ZBG
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![BU of 7zbg by Molmil](/molmil-images/mine/7zbg) | Human Topoisomerase II Beta ATPase ADP | 分子名称: | 4-[(2S,3R)-3-[3,5-bis(oxidanylidene)piperazin-1-ium-1-yl]butan-2-yl]piperazin-4-ium-2,6-dione, ADENOSINE-5'-DIPHOSPHATE, DNA topoisomerase 2-beta, ... | 著者 | Ling, E.M, Basle, A, Cowell, I.G, Blower, T.R, Austin, C.A. | 登録日 | 2022-03-23 | 公開日 | 2022-05-25 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193. Structure, 30, 2022
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7YQ8
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![BU of 7yq8 by Molmil](/molmil-images/mine/7yq8) | Cryo-EM structure of human topoisomerase II beta in complex with DNA and etoposide | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, 50-mer DNA, DNA topoisomerase 2-beta, ... | 著者 | Naganuma, M, Ehara, H, Kim, D, Nakagawa, R, Cong, A, Bu, H, Jeong, J, Jang, J, Schellenberg, M.J, Bunch, H, Sekine, S. | 登録日 | 2022-08-05 | 公開日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes. Nat Commun, 14, 2023
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