7Z9C

E.coli gyrase holocomplex with 217 bp DNA and albicidin

Summary for 7Z9C

• Entry DOI: 10.2210/pdb7z9c/pdb
• EMDB information: 14570
• Descriptor: DNA gyrase subunit A, DNA gyrase subunit B, DNA (5'-D(P*AP*AP*AP*TP*CP*TP*GP*TP*GP*CP*GP*GP*GP*T)-3'), ... (9 entities in total)
• Functional Keywords: type ii topoisomerase, antibiotic, albicidin, dna gyrase, isomerase
• Biological source: Escherichia coli str. K-12 substr. MG1655; More
• Total number of polymer chains: 8
• Total formula weight: 397973.30

Authors

Ghilarov, D.,Heddle, J.G.H.,Suessmuth, R. (deposition date: 2022-03-21, release date: 2023-02-15, Last modification date: 2023-07-19)

• Primary citation: Michalczyk, E.,Hommernick, K.,Behroz, I.,Kulike, M.,Pakosz-Stepien, Z.,Mazurek, L.,Seidel, M.,Kunert, M.,Santos, K.,von Moeller, H.,Loll, B.,Weston, J.B.,Mainz, A.,Heddle, J.G.,Sussmuth, R.D.,Ghilarov, D.; Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin.; Nat Catal, 6:52-67, 2023; PubMed: 36741192; DOI: 10.1038/s41929-022-00904-1

Experimental method

ELECTRON MICROSCOPY (3.06 Å)