4ZVI
GYRASE B IN COMPLEX WITH 4,5-DIBROMOPYRROLAMIDE-BASED INHIBITOR
Summary for 4ZVI
Entry DOI | 10.2210/pdb4zvi/pdb |
Descriptor | DNA gyrase subunit B, N-(4-{[(4,5-dibromo-1H-pyrrol-2-yl)carbonyl]amino}benzoyl)glycine, IODIDE ION, ... (4 entities in total) |
Functional Keywords | gyrase b, inhibitor, gyrb, proteros biostructures gmbh, isomerase |
Biological source | Escherichia coli |
Cellular location | Cytoplasm : P0AES7 |
Total number of polymer chains | 1 |
Total formula weight | 42388.84 |
Authors | Zidar, N.,Macut, H.,Tomasic, T.,Brvar, M.,Montalvao, S.,Tammela, P.,Solmajer, T.,Peterlin Masic, L.,Ilas, J.,Kikelj, D. (deposition date: 2015-05-18, release date: 2015-07-15, Last modification date: 2024-05-08) |
Primary citation | Zidar, N.,Macut, H.,Tomasic, T.,Brvar, M.,Montalvao, S.,Tammela, P.,Solmajer, T.,Peterlin Masic, L.,Ilas, J.,Kikelj, D. N-Phenyl-4,5-dibromopyrrolamides and N-Phenylindolamides as ATP Competitive DNA Gyrase B Inhibitors: Design, Synthesis, and Evaluation. J.Med.Chem., 58:6179-6194, 2015 Cited by PubMed: 26126187DOI: 10.1021/acs.jmedchem.5b00775 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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