7YQ8

Cryo-EM structure of human topoisomerase II beta in complex with DNA and etoposide

Summary for 7YQ8

• Entry DOI: 10.2210/pdb7yq8/pdb
• EMDB information: 34022
• Descriptor: DNA topoisomerase 2-beta, 50-mer DNA, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: topoisomerase, etoposide, dna, isomerase, isomerase-dna complex, isomerase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 429939.50

Authors

Naganuma, M.,Ehara, H.,Kim, D.,Nakagawa, R.,Cong, A.,Bu, H.,Jeong, J.,Jang, J.,Schellenberg, M.J.,Bunch, H.,Sekine, S. (deposition date: 2022-08-05, release date: 2024-01-03)

• Primary citation: Bunch, H.,Kim, D.,Naganuma, M.,Nakagawa, R.,Cong, A.,Jeong, J.,Ehara, H.,Vu, H.,Chang, J.H.,Schellenberg, M.J.,Sekine, S.I.; ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes.; Nat Commun, 14:8341-8341, 2023; PubMed: 38097570; DOI: 10.1038/s41467-023-44089-y

Experimental method

ELECTRON MICROSCOPY (3.9 Å)