7YQ8
Cryo-EM structure of human topoisomerase II beta in complex with DNA and etoposide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DNA topoisomerase 2-beta | polymer | 1626 | 183542.3 | 2 | UniProt (Q02880) Pfam (PF02518) Pfam (PF00204) Pfam (PF01751) Pfam (PF16898) Pfam (PF00521) Pfam (PF08070) | Homo sapiens (human) | DNA topoisomerase II,beta isozyme |
| 2 | C, D (C, D) | 50-mer DNA | polymer | 50 | 15449.9 | 2 | Homo sapiens | ||
| 3 | E, F (E, F) | 50-mer DNA | polymer | 50 | 15364.8 | 2 | Homo sapiens | ||
| 4 | G, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | I, J (D, F) | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside | non-polymer | 588.6 | 2 | Chemie (EVP) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 428713.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1225.7 | |
| All* | Total formula weight | 429939.5 |
