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PDB: 67 件
3S7F
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BU of 3s7f by Molmil
Structural Basis of Substrate Methylation and Inhibition of SMYD2
分子名称: (R,R)-2,3-BUTANEDIOL, N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ...
著者Ferguson, A.D.
登録日2011-05-26
公開日2011-08-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Structural Basis of Substrate Methylation and Inhibition of SMYD2.
Structure, 19, 2011
5XXD
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BU of 5xxd by Molmil
Crystal structure of SmyD3 in complex with covalent inhibitor 1
分子名称: S-ADENOSYLMETHIONINE, Smyd3 methyltransferase, ZINC ION, ...
著者Baburajendran, N, Anna E, J.
登録日2017-07-03
公開日2018-08-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.314 Å)
主引用文献Crystal structure of SmyD3 in complex with covalent inhibitor 1
To Be Published
5XXJ
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Crystal structure of SmyD3 in complex with covalent inhibitor 3
分子名称: S-ADENOSYLMETHIONINE, SMYD3, ZINC ION, ...
著者Baburajendran, N, Jansson, A.E.
登録日2017-07-04
公開日2018-08-08
実験手法X-RAY DIFFRACTION (1.689 Å)
主引用文献Crystal structure of SmyD3 in complex with covalent inhibitor 3
To Be Published
3TG4
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Structure of SMYD2 in complex with SAM
分子名称: GLYCEROL, N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ...
著者Zhao, K, Wang, L.
登録日2011-08-17
公開日2011-08-31
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of human SMYD2 reveals the basis of p53 tumor suppressor methylation
J.Biol.Chem., 2011
5XXG
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Crystal structure of SmyD3 in complex with covalent inhibitor 2
分子名称: S-ADENOSYLMETHIONINE, SMYD3, ZINC ION, ...
著者Baburajendran, N, Jansson, E.A.
登録日2017-07-03
公開日2018-08-08
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Crystal structure of SmyD3 in complex with covalent inhibitor 2
To Be Published
5V37
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BU of 5v37 by Molmil
Crystal structure of SMYD3 with SAM and EPZ028862
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ...
著者Boriack-Sjodin, P.A.
登録日2017-03-06
公開日2018-03-07
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation.
Plos One, 13, 2018
5WCG
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BU of 5wcg by Molmil
SET and MYND Domain Containing protein 2
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DIMETHYL SULFOXIDE, N-lysine methyltransferase SMYD2, ...
著者Dong, A, Zeng, H, Walker, J.R, Hutch, A, Seitova, A, Tatlock, J, Kumpf, R, Owen, A, Taylor, A, Casimiro-Garcia, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC)
登録日2017-06-30
公開日2017-08-02
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献The crystal structure of SMYD2 in complex with compound MTF003
to be published
5YJO
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BU of 5yjo by Molmil
Crystal structure of SmyD3 in complex with covalent inhibitor 4
分子名称: Histone-lysine N-methyltransferase SMYD3, S-ADENOSYLMETHIONINE, ZINC ION, ...
著者Baburajendran, N, Anna E, J.
登録日2017-10-11
公開日2018-10-17
最終更新日2019-07-10
実験手法X-RAY DIFFRACTION (2.135 Å)
主引用文献Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3.
Acs Med.Chem.Lett., 10, 2019
3OXG
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BU of 3oxg by Molmil
human lysine methyltransferase Smyd3 in complex with AdoHcy (Form III)
分子名称: S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 3, ZINC ION
著者Xu, S, Wu, J, Sun, B, Zhong, C, Ding, J.
登録日2010-09-21
公開日2011-02-23
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.41 Å)
主引用文献Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding.
Nucleic Acids Res., 39, 2011
3OXF
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BU of 3oxf by Molmil
Human lysine methyltransferase Smyd3 in complex with AdoHcy (Form I)
分子名称: S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 3, ZINC ION
著者Xu, S, Wu, J, Sun, B, Zhong, C, Ding, J.
登録日2010-09-21
公開日2011-02-23
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding.
Nucleic Acids Res., 39, 2011
3OXL
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BU of 3oxl by Molmil
Human lysine methyltransferase Smyd3 in complex with AdoHcy (Form II)
分子名称: S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 3, ZINC ION
著者Xu, S, Wu, J, Sun, B, Zhong, C, Ding, J.
登録日2010-09-21
公開日2011-02-23
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding
Nucleic Acids Res., 39, 2011
3QWP
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BU of 3qwp by Molmil
Crystal structure of SET and MYND domain containing 3; Zinc finger MYND domain-containing protein 1
分子名称: GLYCEROL, S-ADENOSYLMETHIONINE, SET and MYND domain-containing protein 3, ...
著者Dong, A, Dombrovski, L, Li, Y, Wernimont, A, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC)
登録日2011-02-28
公開日2011-04-06
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献The Crystal Structure of human Histone-lysine N-methyltransferase SMYD3
To be Published
3QWW
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Crystal structure of histone lysine methyltransferase SmyD2 in complex with the methyltransferase inhibitor sinefungin
分子名称: SET and MYND domain-containing protein 2, SINEFUNGIN, ZINC ION
著者Jiang, Y, Sirinupong, N, Brunzelle, J, Yang, Z.
登録日2011-02-28
公開日2011-07-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structures of histone and p53 methyltransferase SmyD2 reveal a conformational flexibility of the autoinhibitory C-terminal domain.
Plos One, 6, 2011
3QWV
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BU of 3qwv by Molmil
Crystal structure of histone lysine methyltransferase SmyD2 in complex with the cofactor product AdoHcy
分子名称: S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 2, ZINC ION
著者Jiang, Y, Sirinupong, N, Brunzelle, J, Yang, Z.
登録日2011-02-28
公開日2011-07-06
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Crystal structures of histone and p53 methyltransferase SmyD2 reveal a conformational flexibility of the autoinhibitory C-terminal domain.
Plos One, 6, 2011
3PDN
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BU of 3pdn by Molmil
Crystal structure of SmyD3 in complex with methyltransferase inhibitor sinefungin
分子名称: GLYCEROL, MAGNESIUM ION, SET and MYND domain-containing protein 3, ...
著者Sirinupong, N, Brunzelle, J, Yang, Z.
登録日2010-10-23
公開日2010-11-17
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Insights into the Autoinhibition and Posttranslational Activation of Histone Methyltransferase SmyD3.
J.Mol.Biol., 406, 2011
3RIB
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BU of 3rib by Molmil
Human lysine methyltransferase Smyd2 in complex with AdoHcy
分子名称: N-lysine methyltransferase SMYD2, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
著者Xu, S, Zhang, T, Zhong, C, Ding, J.
登録日2011-04-13
公開日2011-07-20
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Structure of human lysine methyltransferase Smyd2 reveals insights into the substrate divergence in Smyd proteins
J Mol Cell Biol, 3, 2011
3RU0
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BU of 3ru0 by Molmil
Cocrystal structure of human SMYD3 with inhibitor Sinefungin bound
分子名称: SET and MYND domain-containing protein 3, SINEFUNGIN, ZINC ION
著者Foreman, K.W, Brown, M, Park, F, Emtage, S, Harriss, J, Das, C, Zhu, L, Crew, A, Arnold, L, Shaaban, S, Tucker, P.
登録日2011-05-04
公開日2011-05-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.849 Å)
主引用文献Structural and Functional Profiling of the Human Histone Methyltransferase SMYD3.
Plos One, 6, 2011
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