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PDB: 150 件
4U2H
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The crystal structure of apo CalE6, a methionine gamma lyase from Micromonospora echinospora
分子名称: CalE6, SULFATE ION
著者Song, H.G, Xu, R.
登録日2014-07-17
公開日2015-01-07
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Identification and Characterization of a Methionine gamma-Lyase in the Calicheamicin Biosynthetic Cluster of Micromonospora echinospora
Chembiochem, 16, 2015
4XQ2
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Ensemble refinement of cystathione gamma lyase (CalE6) D7G from Micromonospora echinospora
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, CalE6, ...
著者Wang, F, Yennamalli, R.M, Singh, S, Tan, K, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2015-01-18
公開日2015-04-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The crystal structure of cystathione gamma lyase (CalE6) from Micromonospora echinospora
To Be Published
3COG
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Crystal structure of human cystathionase (Cystathionine gamma lyase) in complex with DL-propargylglycine
分子名称: (2S)-2-aminopent-4-enoic acid, Cystathionine gamma-lyase, DI(HYDROXYETHYL)ETHER, ...
著者Collins, R, Karlberg, T, Lehtio, L, Arrowsmith, C.H, Berglund, H, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Kallas, A, Kotenyova, T, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Olesen, K, Persson, C, Schuler, H, Svensson, L, Thorsell, A.G, Tresaugues, L, Van den Berg, S, Sagermark, J, Busam, R.D, Welin, M, Weigelt, J, Wikstrom, M, Structural Genomics Consortium (SGC)
登録日2008-03-28
公開日2008-05-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S.
J.Biol.Chem., 284, 2009
2RFV
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BU of 2rfv by Molmil
High resolution structure of L-methionine gamma-lyase from Citrobacter freundii
分子名称: CHLORIDE ION, Methionine gamma-lyase
著者Nikulin, A.D, Revtovich, S.V, Morozova, E.A, Nevskaya, N.A, Nikonov, S.V, Garber, M.B, Demidkina, T.V.
登録日2007-10-02
公開日2008-08-19
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.355 Å)
主引用文献High-resolution structure of methionine gamma-lyase from Citrobacter freundii.
Acta Crystallogr.,Sect.D, 64, 2008
3MKJ
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Methionine gamma-lyase from Citrobacter freundii with pyridoximine-5'-phosphate
分子名称: Methionine gamma-lyase, [5-hydroxy-4-(iminomethyl)-6-methyl-pyridin-3-yl]methyl dihydrogen phosphate
著者Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Demidkina, T.V.
登録日2010-04-15
公開日2010-08-11
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Exploring methionine gamma-lyase structure-function relationship via microspectrophotometry and X-ray crystallography
Biochim.Biophys.Acta, 1814, 2011
4KAM
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BU of 4kam by Molmil
X-ray crystal structure of O-acetylhomoserine sulfhydrylase MetC from Mycobacterium marinum ATCC BAA-535 / M
分子名称: O-acetylhomoserine sulfhydrylase MetC, SULFATE ION
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2013-04-22
公開日2013-05-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
8SF4
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BU of 8sf4 by Molmil
Cystathionine gamma lyase from Thermobifida fusca in internal aldimine form
分子名称: Cystathionine gamma-lyase, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ...
著者Perkins, L.J, Buller, A.R, Bindman, C.A.
登録日2023-04-10
公開日2024-07-03
実験手法X-RAY DIFFRACTION (1.455 Å)
主引用文献Multiplexed deconvolution of enzyme function in a PLP-dependent protein family
To Be Published
7SWH
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Crystal Structure of Putative cystathionine gamma-synthase from Burkholderia pseudomallei in Complex with PLP
分子名称: 1,2-ETHANEDIOL, Putative cystathionine gamma-synthase
著者Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2021-11-19
公開日2021-12-01
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal Structure of Putative cystathionine gamma-synthase from Burkholderia pseudomallei in Complex with PLP
to be published
6EGR
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Crystal structure of Citrobacter freundii methionine gamma-lyase with V358Y replacement
分子名称: DI(HYDROXYETHYL)ETHER, Methionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE, ...
著者Revtovich, S.V, Demitri, N, Raboni, S, Nikulin, A.D, Morozova, E.A, Demidkina, T.V, Storici, P, Mozzarelli, A.
登録日2017-09-12
公開日2018-10-10
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Engineering methionine gamma-lyase from Citrobacter freundii for anticancer activity.
Biochim Biophys Acta Proteins Proteom, 1866, 2018
5M3Z
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Crystal structure of Citrobacter freundii methionine gamma-lyase with C115H replacement in the complex with L-norleucine
分子名称: 2-[O-PHOSPHONOPYRIDOXYL]-AMINO-HEXANOIC ACID, Methionine gamma-lyase, NORLEUCINE, ...
著者Revtovich, S.V, Nikulin, A.D, Anufrieva, N.V, Morozova, E.A, Demidkina, T.V.
登録日2016-10-17
公開日2017-06-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Crystal structure of mutant form Cys115His of Citrobacter freundii methionine gamma-lyase complexed with l-norleucine.
Biochim. Biophys. Acta, 1865, 2017
8DUY
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BU of 8duy by Molmil
Crystal structure of Cystathionine beta-lyase from Klebsiella pneumoniae
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Cystathionine beta-lyase
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2022-07-27
公開日2022-08-10
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structure of Cystathionine beta-lyase from Klebsiella pneumoniae
To be Published
1UKJ
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BU of 1ukj by Molmil
Detailed structure of L-Methionine-Lyase from Pseudomonas putida
分子名称: Methionine gamma-lyase, SULFATE ION
著者Misaki, S, Takimoto, A, Takakura, T, Yoshioka, T, Yamashita, M, Tamura, T, Tanaka, H, Inagaki, K.
登録日2003-08-24
公開日2004-10-19
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Detailed structure of L-Methionine -Lyase from Pseudomonas putida
To be Published
5D5S
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BU of 5d5s by Molmil
Crystal structure of methionine gamma-lyase from Citrobacter freundii, S339A mutant
分子名称: DI(HYDROXYETHYL)ETHER, Methionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE, ...
著者Revtovich, S.V, Nikulin, A.D, Anufrieva, N.V, Morozova, E.A, Demidkina, T.V.
登録日2015-08-11
公開日2016-08-17
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The crystal structure of methionine gamma-lyase from Citrobacter freundii, S339A mutant
To Be Published
3NDN
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BU of 3ndn by Molmil
Crystal structure of O-succinylhomoserine sulfhydrylase from Mycobacterium tuberculosis covalently bound to pyridoxal-5-phosphate
分子名称: O-succinylhomoserine sulfhydrylase
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2010-06-07
公開日2010-06-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
7YEO
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BU of 7yeo by Molmil
Crystal Structure of cystathionine gamma-synthase-like protein C23A1.14c
分子名称: MAGNESIUM ION, PYRIDOXAL-5'-PHOSPHATE, Uncharacterized trans-sulfuration enzyme C23A1.14c
著者Zhang, S.J.
登録日2022-07-06
公開日2023-01-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure of cystathionine gamma-synthase-like protein C23A1.14c
To Be Published
6S0C
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Crystal structure of methionine gamma-lyase from Citrobacter freundii modified by dimethylthiosulfinate
分子名称: Cystathionine gamma-synthase, PYRIDOXAL-5'-PHOSPHATE, TRIETHYLENE GLYCOL
著者Revtovich, S.V, Morozova, E.A, Nikulin, A.D, Demidkina, T.V.
登録日2019-06-14
公開日2020-04-22
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Sulfoxides of sulfur-containing amino acids are suicide substrates of Citrobacter freundii methionine gamma-lyase. Structural bases of the enzyme inactivation.
Biochimie, 168, 2020
1Y4I
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BU of 1y4i by Molmil
Crystal structure of Citrobacter Freundii L-methionine-lyase
分子名称: SULFATE ION, methionine gamma-lyase
著者Revtovich, S.V, Mamaeva, D.V, Morozova, E.A, Nikulin, A.D, Nikonov, S.V, Garber, M.B, Demidkina, T.V.
登録日2004-12-01
公開日2005-06-14
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of Citrobacter freundii L-methionine gamma-lyase.
Acta Crystallogr.,Sect.F, 61, 2005
1N8P
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Crystal Structure of cystathionine gamma-lyase from yeast
分子名称: Cystathionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE
著者Messerschmidt, A, Worbs, M, Steegborn, C, Wahl, M.C, Huber, R, Clausen, T.
登録日2002-11-21
公開日2002-12-04
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Determinants of Enzymatic Specificity in the Cys-Met-Metabolism PLP-Dependent Enzymes Family: Crystal Structure of Cystathionine gamma-lyase from Yeast and Intrafamiliar Structural Comparison
BIOL.CHEM., 384, 2003
6NBA
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Crystal structure of Human Cystathionine gamma lyase with S-3-Carboxpropyl-L-Cysteine
分子名称: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Cystathionine gamma-lyase
著者Kim, H, Yadav, P.K, Banerjee, R, Cho, U.-S.
登録日2018-12-06
公開日2019-06-12
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.495 Å)
主引用文献S-3-Carboxypropyl-l-cysteine specifically inhibits cystathionine gamma-lyase-dependent hydrogen sulfide synthesis.
J.Biol.Chem., 294, 2019
2NMP
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Crystal structure of human Cystathionine gamma lyase
分子名称: Cystathionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE
著者Karlberg, T, Uppenberg, J, Arrowsmith, C, Berglund, H, Busam, R.D, Collins, R, Edwards, A, Ericsson, U.B, Flodin, S, Flores, A, Graslund, S, Hallberg, B.M, Hammarstrom, M, Hogbom, M, Johansson, I, Kotenyova, T, Magnusdottir, A, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, van-den-Berg, S, Wallden, K, Weigelt, J, Holmberg-Schiavone, L, Structural Genomics Consortium (SGC)
登録日2006-10-23
公開日2006-11-07
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S
J.Biol.Chem., 284, 2009
6OVG
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BU of 6ovg by Molmil
L-Methionine Depletion with an Engineered Human Enzyme Disrupts Prostate Cancer Metabolism
分子名称: Cystathionine gamma-lyase, SULFATE ION
著者Yan, W, Irani, S, Zhang, J.
登録日2019-05-07
公開日2020-04-22
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.719 Å)
主引用文献Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.
Proc.Natl.Acad.Sci.USA, 117, 2020
5TT2
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Inactive conformation of engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine
分子名称: Cystathionine gamma-lyase, SULFATE ION
著者Yan, W, Zhang, Y.
登録日2016-10-31
公開日2017-10-11
最終更新日2019-11-27
実験手法X-RAY DIFFRACTION (2.949 Å)
主引用文献Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry, 56, 2017
5K30
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Crystal structure of methionine gamma-lyase from Citrobacter freundii modified by S-Ethyl-L-cysteine sulfoxide
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, Methionine gamma-lyase, ...
著者Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Demidkina, T.V.
登録日2016-05-19
公開日2017-07-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Sulfoxides of sulfur-containing amino acids are suicide substrates of Citrobacter freundii methionine gamma-lyase. Structural bases of the enzyme inactivation.
Biochimie, 168, 2020
5EIG
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Engineered human cystathionine gamma lyase (E59T, E339V) to deplet cysteine
分子名称: CYSTEINE, Cystathionine gamma-lyase, SULFATE ION
著者Yan, W, Zhang, J.
登録日2015-10-29
公開日2016-11-09
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Systemic Depletion of Serum L-Cyst(e)ine with an Engineered Human Enzyme Mediates Potent Induction of ROS and Cancer Ablation
To Be Published
5IJG
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Crystal structure of O-acetylhomoserine sulfhydrolase from Brucella melitensis at 2.0 A resolution
分子名称: Cys/Met metabolism pyridoxal-phosphate-dependent enzyme, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE
著者Boyko, K.M, Nikolaeva, A.Y, Koolikova, V.V, Kotlov, M.I, Demidkina, T.V, Popov, V.O.
登録日2016-03-02
公開日2017-04-05
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of O-acetylhomoserine sulfhydrolase from Brucella melitensis at 2.0 A resolution
To Be Published

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