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PDB: 592 件
6N6V
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BU of 6n6v by Molmil
OXA-23 mutant F110A/M221A low pH form meropenem complex
分子名称: Beta-lactamase, meropenem, bound form
著者Smith, C.A, Vakulenko, S.B.
登録日2018-11-27
公開日2018-12-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Role of the Hydrophobic Bridge in the Carbapenemase Activity of Class D beta-Lactamases.
Antimicrob. Agents Chemother., 63, 2019
7R6Z
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BU of 7r6z by Molmil
OXA-48 bound by Compound 3.3
分子名称: 1,2-ETHANEDIOL, 4-amino-5-hydroxynaphthalene-2,7-disulfonic acid, Beta-lactamase, ...
著者Taylor, D.M, Hu, L, Prasad, B.V.V, Sankaran, B, Palzkill, T.
登録日2021-06-24
公開日2021-12-01
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48.
Acs Infect Dis., 7, 2021
6NHS
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BU of 6nhs by Molmil
Crystal Structure of the Beta Lactamase Class D YbXI from Nostoc
分子名称: 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ...
著者Kim, Y, Tesar, C, Endres, M, Babnigg, G, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2018-12-23
公開日2019-01-16
最終更新日2019-12-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of the Beta Lactamase Class D YbXI from Nostoc
To Be Published
7RPA
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BU of 7rpa by Molmil
X-ray crystal structure of OXA-24/40 K84D in complex with meropenem
分子名称: (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, BICARBONATE ION, Beta-lactamase, ...
著者Powers, R.A, Mitchell, J.M, June, C.M.
登録日2021-08-03
公開日2022-07-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40.
J.Biol.Chem., 298, 2022
7RP9
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BU of 7rp9 by Molmil
X-ray crystal structure of OXA-24/40 V130D in complex with imipenem
分子名称: (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-ca rboxylic acid, BICARBONATE ION, Beta-lactamase, ...
著者Powers, R.A, Mitchell, J.M, June, C.M.
登録日2021-08-03
公開日2022-07-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40.
J.Biol.Chem., 298, 2022
7RP8
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X-ray crystal structure of OXA-24/40 K84D in complex with imipenem
分子名称: Beta-lactamase, Imipenem, SULFATE ION
著者Powers, R.A, Mitchell, J.M, June, C.M.
登録日2021-08-03
公開日2022-07-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40.
J.Biol.Chem., 298, 2022
7RPE
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X-ray crystal structure of OXA-24/40 in complex with ertapenem
分子名称: (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, BICARBONATE ION, Beta-lactamase, ...
著者Powers, R.A, Mitchell, J.M, June, C.M.
登録日2021-08-03
公開日2022-07-06
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40.
J.Biol.Chem., 298, 2022
7RPD
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X-ray crystal structure of OXA-24/40 V130D in complex with ertapenem
分子名称: (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, BICARBONATE ION, Beta-lactamase, ...
著者Powers, R.A, Mitchell, J.M, June, C.M.
登録日2021-08-03
公開日2022-07-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40.
J.Biol.Chem., 298, 2022
7RPC
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X-ray crystal structure of OXA-24/40 K84D in complex with ertapenem
分子名称: (1S,4R,5S,6S)-3-{[(3S,5S)-5-carbamoylpyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, BICARBONATE ION, Beta-lactamase, ...
著者Powers, R.A, Mitchell, J.M, June, C.M.
登録日2021-08-03
公開日2022-07-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40.
J.Biol.Chem., 298, 2022
7RPF
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BU of 7rpf by Molmil
X-ray crystal structure of OXA-24/40 in complex with doripenem
分子名称: (2S,3R,4S)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-4-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-3,4-dihydro-2H-pyrrole-5-carboxylic acid, (4R,5S)-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-3-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid, BICARBONATE ION, ...
著者Powers, R.A, Mitchell, J.M, June, C.M.
登録日2021-08-03
公開日2022-07-06
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40.
J.Biol.Chem., 298, 2022
7RPB
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BU of 7rpb by Molmil
X-ray crystal structure of OXA-24/40 V130D in complex with meropenem
分子名称: (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, BICARBONATE ION, Beta-lactamase
著者Powers, R.A, Mitchell, J.M, June, C.M.
登録日2021-08-03
公開日2022-07-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40.
J.Biol.Chem., 298, 2022
7RPG
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X-ray crystal structure of OXA-24/40 K84D in complex with cefotaxime
分子名称: Beta-lactamase, CEFOTAXIME, C3' cleaved, ...
著者Powers, R.A, Mitchell, J.M, June, C.M.
登録日2021-08-03
公開日2022-07-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40.
J.Biol.Chem., 298, 2022
6N6Y
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BU of 6n6y by Molmil
OXA-23 mutant F110A/M221A neutral pH form meropenem complex
分子名称: Beta-lactamase oxa23, meropenem, bound form
著者Smith, C.A, Vakulenko, S.B.
登録日2018-11-27
公開日2018-12-19
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.501 Å)
主引用文献Role of the Hydrophobic Bridge in the Carbapenemase Activity of Class D beta-Lactamases.
Antimicrob. Agents Chemother., 63, 2019
6NZ8
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BU of 6nz8 by Molmil
Structure of carbamylated apo OXA-231 carbapenemase
分子名称: Beta-lactamase OXA-231, CHLORIDE ION, SODIUM ION
著者Favaro, D.C, Llontop, E.E, Vasconcelos, F.N, Antunes, V.U, Farah, S.C, Lincopan, N.
登録日2019-02-13
公開日2020-02-19
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Importance of the beta 5-beta 6 Loop for the Structure, Catalytic Efficiency, and Stability of Carbapenem-Hydrolyzing Class D beta-Lactamase Subfamily OXA-143.
Biochemistry, 58, 2019
6N6X
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BU of 6n6x by Molmil
OXA-23 mutant F110A/M221A neutral pH form imipenem complex
分子名称: Beta-lactamase oxa23, Imipenem, SULFATE ION
著者Smith, C.A, Vakulenko, S.B.
登録日2018-11-27
公開日2018-12-19
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Role of the Hydrophobic Bridge in the Carbapenemase Activity of Class D beta-Lactamases.
Antimicrob. Agents Chemother., 63, 2019
6N6U
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BU of 6n6u by Molmil
OXA-23 mutant F110A/M221A low pH form imipenem complex
分子名称: Beta-lactamase, Imipenem
著者Smith, C.A, Vakulenko, S.B.
登録日2018-11-27
公開日2018-12-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Role of the Hydrophobic Bridge in the Carbapenemase Activity of Class D beta-Lactamases.
Antimicrob. Agents Chemother., 63, 2019
6NLW
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BU of 6nlw by Molmil
The crystal structure of class D carbapenem-hydrolyzing beta-lactamase BlaA from Shewanella oneidensis MR-1
分子名称: Beta-lactamase, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者Tan, K, Tesar, C, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2019-01-09
公開日2019-01-23
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献The crystal structure of class D carbapenem-hydrolyzing beta-lactamase BlaA from Shewanella oneidensis MR-1
To Be Published
6NHU
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BU of 6nhu by Molmil
Crystal Structure of the Beta Lactamase Class D YbxI from Agrobacterium fabrum
分子名称: 1,2-ETHANEDIOL, Beta-lactamase, GLYCEROL, ...
著者Kim, Y, Welk, L, Endres, M, Babnigg, G, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2018-12-23
公開日2019-01-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of the Beta Lactamase Class D YbxI from Agrobacterium fabrum
To Be Published
6O9S
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BU of 6o9s by Molmil
Crystal structure of Staphylococcus aureus MecR1 antibiotic-sensor domain in complex with avibactam
分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Methicillin resistance mecR1 protein, SULFATE ION
著者Alexander, J.A.N, Strynadka, N.C.J.
登録日2019-03-14
公開日2020-06-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus .
J.Biol.Chem., 295, 2020
6O9W
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BU of 6o9w by Molmil
Crystal structure of Staphylococcus aureus BlaR1 antibiotic-sensor domain in complex with avibactam
分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Regulatory protein BlaR1
著者Alexander, J.A.N, Strynadka, N.C.J.
登録日2019-03-15
公開日2020-06-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus .
J.Biol.Chem., 295, 2020
6N1N
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BU of 6n1n by Molmil
Crystal structure of class D beta-lactamase from Sebaldella termitidis ATCC 33386
分子名称: Beta-lactamase, GLYCEROL, SULFATE ION
著者Michalska, K, Tesar, C, Endres, M, Joachimiak, A, Satchell, K.J, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2018-11-09
公開日2018-12-19
最終更新日2019-12-18
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献Crystal structure of class D beta-lactamase from Sebaldella termitidis ATCC 33386
To Be Published
6N6T
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BU of 6n6t by Molmil
OXA-23 mutant F110A/M221A low pH form
分子名称: Beta-lactamase oxa23, CITRATE ANION
著者Smith, C.A, Vakulenko, S.B.
登録日2018-11-27
公開日2018-12-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Role of the Hydrophobic Bridge in the Carbapenemase Activity of Class D beta-Lactamases.
Antimicrob. Agents Chemother., 63, 2019
6HZI
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BU of 6hzi by Molmil
Apo structure of TP domain from Burkholderia pseudomallei penicillin-binding protein 3
分子名称: Peptidoglycan D,D-transpeptidase FtsI
著者Bellini, D, Koekemoer, L, Newman, H, Dowson, C.G.
登録日2018-10-23
公開日2019-11-20
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Apo structure of TP domain from Burkholderia pseudomallei penicillin-binding protein 3
To Be Published
6I5D
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BU of 6i5d by Molmil
Crystal structure of an OXA-48 beta-lactamase synthetic mutant
分子名称: 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ...
著者Zavala, A, Retailleau, P, Dabos, L, Naas, T, Iorga, B.
登録日2018-11-13
公開日2020-03-04
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Substrate specificity of an OXA-48 beta-lactamase synthetic mutant
To be published
6HUH
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CRYSTAL STRUCTURE OF OXA-427 class D BETA-LACTAMASE
分子名称: Beta-lactamase, SULFATE ION
著者Zavala, A, Retailleau, P, Bogaerts, P, Glupczynski, Y, Naas, T, Iorga, B.
登録日2018-10-08
公開日2019-10-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献CRYSTAL STRUCTURE OF CMY-OXA-427-HisTag BETA-LACTAMASE
To be published

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件を2024-06-12に公開中

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