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PDB: 381 件
7MET
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A. baumannii MsbA in complex with TBT1 decoupler
分子名称: 2-(4-chlorobenzamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid, ATP-dependent lipid A-core flippase
著者Thelot, F, Liao, M.
登録日2021-04-07
公開日2021-10-06
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.97 Å)
主引用文献Distinct allosteric mechanisms of first-generation MsbA inhibitors.
Science, 374, 2021
7MJP
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Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Sung, M.W, Shyng, S.L.
登録日2021-04-20
公開日2021-10-13
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MJQ
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Vascular KATP channel: Kir6.1 SUR2B quatrefoil-like conformation 2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ATP-sensitive inward rectifier potassium channel 8, ...
著者Sung, M.W, Shyng, S.L.
登録日2021-04-20
公開日2021-10-13
最終更新日2022-10-26
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MJO
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Vascular KATP channel: Kir6.1 SUR2B quatrefoil-like conformation 1
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ...
著者Sung, M.W, Shyng, S.L.
登録日2021-04-20
公開日2021-10-13
最終更新日2022-10-26
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M69
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E1435Q Ycf1 mutant in inward-facing wide conformation
分子名称: Metal resistance protein YCF1
著者Khandelwal, N.K, Millan, C.R, Thaker, T.M, Tomasiak, T.M.
登録日2021-03-25
公開日2022-04-06
最終更新日2022-10-19
実験手法ELECTRON MICROSCOPY (3.42 Å)
主引用文献The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation.
Nat Commun, 13, 2022
7M68
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E1435Q Ycf1 mutant in inward-facing narrow conformation
分子名称: Metal resistance protein YCF1
著者Khandelwal, N.K, Millan, C.R, Thaker, T.M, Tomasiak, T.M.
登録日2021-03-25
公開日2022-04-06
最終更新日2022-10-19
実験手法ELECTRON MICROSCOPY (4.04 Å)
主引用文献The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation.
Nat Commun, 13, 2022
7MIT
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Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 1
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ...
著者Sung, M.W, Shyng, S.L.
登録日2021-04-17
公開日2021-10-13
最終更新日2023-08-16
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021
7NIU
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Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab and QA2-Fab (apo-inward-open conformation)
分子名称: 4B1 Fab-fragment heavy chain, 4B1 Fab-fragment light chain, CHOLESTEROL, ...
著者Nosol, K, Locher, K.P.
登録日2021-02-14
公開日2021-08-25
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structures of ABCB4 provide insight into phosphatidylcholine translocation.
Proc.Natl.Acad.Sci.USA, 118, 2021
7NIV
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Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab and QA2-Fab (phosphatidylcholine-bound, occluded conformation)
分子名称: 1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 4B1 Fab-fragment light chain, CHOLESTEROL, ...
著者Nosol, K, Locher, K.P.
登録日2021-02-14
公開日2021-08-25
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structures of ABCB4 provide insight into phosphatidylcholine translocation.
Proc.Natl.Acad.Sci.USA, 118, 2021
7NIW
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Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab (posaconazole-bound, inward-open conformation)
分子名称: 1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 4B1 Fab-fragment heavy chain, 4B1 Fab-fragment light chain, ...
著者Nosol, K, Locher, K.P.
登録日2021-02-14
公開日2021-08-25
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structures of ABCB4 provide insight into phosphatidylcholine translocation.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N5B
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Structure of AtAtm3 in the outward-facing conformation
分子名称: ABC transporter B family member 25, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, ...
著者Fan, C, Rees, D.C.
登録日2021-06-05
公開日2022-04-13
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Glutathione binding to the plant At Atm3 transporter and implications for the conformational coupling of ABC transporters.
Elife, 11, 2022
7N58
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Structure of AtAtm3 in the inward-facing conformation
分子名称: ABC transporter B family member 25, mitochondrial
著者Fan, C, Rees, D.C.
登録日2021-06-05
公開日2022-04-13
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Glutathione binding to the plant At Atm3 transporter and implications for the conformational coupling of ABC transporters.
Elife, 11, 2022
7N59
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Structure of AtAtm3 in the inward-facing conformation with GSSG bound
分子名称: ABC transporter B family member 25, mitochondrial, OXIDIZED GLUTATHIONE DISULFIDE
著者Fan, C, Rees, D.C.
登録日2021-06-05
公開日2022-04-13
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Glutathione binding to the plant At Atm3 transporter and implications for the conformational coupling of ABC transporters.
Elife, 11, 2022
7N5A
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Structure of AtAtm3 in the closed conformation
分子名称: ABC transporter B family member 25, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, ...
著者Fan, C, Rees, D.C.
登録日2021-06-05
公開日2022-04-13
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.95 Å)
主引用文献Glutathione binding to the plant At Atm3 transporter and implications for the conformational coupling of ABC transporters.
Elife, 11, 2022
7M33
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The structure of Bacillus subtilis BmrCD in the inward-facing conformation bound to Hoechst-33342 and ATP
分子名称: 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, ADENOSINE-5'-TRIPHOSPHATE, Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH, ...
著者Thaker, T.M, Tomasiak, T.M.
登録日2021-03-18
公開日2022-01-05
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.55 Å)
主引用文献Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter.
Nat.Chem.Biol., 18, 2022
7O9W
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Encequidar-bound human P-glycoprotein in complex with UIC2-Fab
分子名称: Multidrug resistance protein 1, UIC2 Fab-fragment heavy chain, UIC2 Fab-fragment light chain, ...
著者Nosol, K, Locher, K.P.
登録日2021-04-17
公開日2022-01-12
最終更新日2022-01-26
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations.
J.Med.Chem., 65, 2022
7OCY
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BU of 7ocy by Molmil
Enterococcus faecalis EfrCD in complex with a nanobody
分子名称: ABC transporter ATP-binding protein, Nanobody
著者Ehrenbolger, K, Hutter, C.A.J, Meier, G, Seeger, M.A, Barandun, J.
登録日2021-04-28
公開日2022-05-18
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (4.25 Å)
主引用文献Deep mutational scan of a drug efflux pump reveals its structure-function landscape.
Nat.Chem.Biol., 19, 2023
8JW4
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BU of 8jw4 by Molmil
Cryo-EM structure of Plasmodium falciparum multidrug resistance protein 1 in the apo state without H1 helix
分子名称: Multidrug resistance protein 1
著者Li, M, Si, K.
登録日2023-06-28
公開日2023-08-30
実験手法ELECTRON MICROSCOPY (3.13 Å)
主引用文献The structure of Plasmodium falciparum multidrug resistance protein 1 reveals an N-terminal regulatory domain.
Proc.Natl.Acad.Sci.USA, 120, 2023
8JWG
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Cryo-EM structure of Plasmodium falciparum multidrug resistance protein 1 without H1 helix in complex with MFQ
分子名称: Mefloquine, Multidrug resistance protein 1
著者Li, M, Si, K.
登録日2023-06-29
公開日2023-08-30
実験手法ELECTRON MICROSCOPY (3.54 Å)
主引用文献The structure of Plasmodium falciparum multidrug resistance protein 1 reveals an N-terminal regulatory domain.
Proc.Natl.Acad.Sci.USA, 120, 2023
8JWI
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Cryo-EM structure of the outward-facing Plasmodium falciparum multidrug resistance protein 1
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug resistance protein 1
著者Li, M, Si, K.
登録日2023-06-29
公開日2023-08-30
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献The structure of Plasmodium falciparum multidrug resistance protein 1 reveals an N-terminal regulatory domain.
Proc.Natl.Acad.Sci.USA, 120, 2023
8JWF
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BU of 8jwf by Molmil
Cryo-EM structure of Plasmodium falciparum multidrug resistance protein 1 with H1 helix in complex with MFQ
分子名称: Mefloquine, Multidrug resistance protein 1
著者Li, M, Si, K.
登録日2023-06-29
公開日2023-08-30
実験手法ELECTRON MICROSCOPY (3.64 Å)
主引用文献The structure of Plasmodium falciparum multidrug resistance protein 1 reveals an N-terminal regulatory domain.
Proc.Natl.Acad.Sci.USA, 120, 2023
8JVH
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BU of 8jvh by Molmil
Cryo-EM structure of Plasmodium falciparum multidrug resistance protein 1 in the apo state with H1 helix
分子名称: Multidrug resistance protein 1
著者Li, M, Si, K.
登録日2023-06-28
公開日2023-08-30
実験手法ELECTRON MICROSCOPY (3.19 Å)
主引用文献The structure of Plasmodium falciparum multidrug resistance protein 1 reveals an N-terminal regulatory domain.
Proc.Natl.Acad.Sci.USA, 120, 2023
8K7C
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BU of 8k7c by Molmil
Outward-facing structure of human ABCB6 W546A mutant (ADP/VO4-bound)
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family B member 6, MAGNESIUM ION, ...
著者Jin, M.S, Lee, S.S, Park, J.G, Jang, E, Choi, S.H, Kim, S, Kim, J.W.
登録日2023-07-26
公開日2023-10-04
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献W546 stacking disruption traps the human porphyrin transporter ABCB6 in an outward-facing transient state.
Commun Biol, 6, 2023
8K7B
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post-occluded structure of human ABCB6 W546A mutant (ADP/VO4-bound)
分子名称: (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, ADP ORTHOVANADATE, ATP-binding cassette sub-family B member 6, ...
著者Jin, M.S, Lee, S.S, Park, J.G, Jang, E, Choi, S.H, Kim, S, Kim, J.W.
登録日2023-07-26
公開日2023-10-04
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献W546 stacking disruption traps the human porphyrin transporter ABCB6 in an outward-facing transient state.
Commun Biol, 6, 2023
8K7A
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Cryo-EM structure of nucleotide-bound ComA E647Q mutant with Mg2+
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Transport/processing ATP-binding protein ComA
著者Yu, L, Xin, X, Min, L.
登録日2023-07-26
公開日2023-10-11
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structural basis of peptide secretion for Quorum sensing by ComA.
Nat Commun, 14, 2023

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