1QMC
| C-terminal DNA-binding domain of HIV-1 integrase, NMR, 42 structures | 分子名称: | HIV-1 INTEGRASE | 著者 | Eijkelenboom, A.P.A.M, Sprangers, R, Hard, K, Puras Lutzke, R.A, Plasterk, R.H.A, Boelens, R, Kaptein, R. | 登録日 | 1999-09-27 | 公開日 | 1999-12-14 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Refined Solution Structure of the C-Terminal DNA-Binding Domain of Human Immunovirus-1 Integrase. Proteins: Struct.,Funct., Genet., 36, 1999
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5D7U
| Crystal structure of the C-terminal domain of MMTV integrase | 分子名称: | ISOPROPYL ALCOHOL, Pr160 | 著者 | Cook, N.J, Pye, V.E, Ballandras-Colas, A, Engelman, A, Cherepanov, P. | 登録日 | 2015-08-14 | 公開日 | 2016-02-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature, 530, 2016
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1IHV
| SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, MINIMIZED AVERAGE STRUCTURE | 分子名称: | HIV-1 INTEGRASE | 著者 | Clore, G.M, Lodi, P.J, Ernst, J.A, Gronenborn, A.M. | 登録日 | 1995-05-12 | 公開日 | 1996-10-14 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the DNA binding domain of HIV-1 integrase. Biochemistry, 34, 1995
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1IHW
| SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 40 STRUCTURES | 分子名称: | HIV-1 INTEGRASE | 著者 | Clore, G.M, Lodi, P.J, Ernst, J.A, Gronenborn, A.M. | 登録日 | 1995-05-12 | 公開日 | 1996-07-11 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the DNA binding domain of HIV-1 integrase. Biochemistry, 34, 1995
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5TC2
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6TJU
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6T6I
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6T6E
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6T6J
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5HOT
| Structural Basis for Inhibitor-Induced Aggregation of HIV-1 Integrase | 分子名称: | (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid, Integrase | 著者 | Gupta, K, Turkki, V, Sherrill-Mix, S, Hwang, Y, Eilers, G, Taylor, L, McDanal, C, Wang, P, Temelkoff, D, Nolte, R, Velthuisen, E, Jeffrey, J, Van Duyne, G.D, Bushman, F.D. | 登録日 | 2016-01-19 | 公開日 | 2016-12-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | 主引用文献 | Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol., 14, 2016
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7PEL
| CryoEM structure of simian T-cell lymphotropic virus intasome in complex with PP2A regulatory subunit B56 gamma | 分子名称: | DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*AP*GP*AP*AP*GP*CP*GP*CP*CP*AP*AP*AP*CP*AP*CP*A)-3'), Isoform 3 of PC4 and SFRS1-interacting protein,Isoform Gamma-2 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, ... | 著者 | Barski, M, Pye, V.E, Nans, A, Cherepanov, P, Maertens, G.N. | 登録日 | 2021-08-10 | 公開日 | 2021-08-25 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56gamma. Nat Commun, 11, 2020
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5EJK
| Crystal structure of the Rous sarcoma virus intasome | 分子名称: | DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*TP*AP*CP*TP*C)-3'), DNA (5'-D(*AP*GP*TP*GP*TP*CP*TP*T)-3'), DNA (5'-D(*CP*TP*TP*CP*TP*CP*TP*C)-3'), ... | 著者 | Yin, Z, Shi, K, Banerjee, S, Aihara, H. | 登録日 | 2015-11-02 | 公開日 | 2016-02-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Crystal structure of the Rous sarcoma virus intasome. Nature, 530, 2016
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8CTA
| Minimal 2:2 Ternary Complex between BI-224436 bound HIV-1 Integrase Catalytic Core Domain Dimer and Carboxy Terminal Domains | 分子名称: | (2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid, 1,2-ETHANEDIOL, Integrase | 著者 | Gupta, K, Van Duyne, G.D, Eilers, G, Bushman, F.D. | 登録日 | 2022-05-13 | 公開日 | 2023-02-22 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | 主引用文献 | Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 angstrom resolution: Routes to inhibitor optimization. Plos Pathog., 19, 2023
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3JCA
| Core model of the Mouse Mammary Tumor Virus intasome | 分子名称: | 5'-D(*AP*AP*TP*GP*CP*CP*GP*CP*AP*GP*TP*CP*GP*GP*CP*CP*GP*AP*CP*CP*TP*G)-3', 5'-D(*CP*AP*GP*GP*TP*CP*GP*GP*CP*CP*GP*AP*CP*TP*GP*CP*GP*GP*CP*A)-3', Integrase, ... | 著者 | Lyumkis, D.L, Ballandras-Colas, A, Brown, M, Cook, N.J, Dewdney, T.G, Demeler, B, Cherepanov, P, Engelman, A.N. | 登録日 | 2015-11-24 | 公開日 | 2016-02-17 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature, 530, 2016
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4FW1
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5U1C
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7UT1
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7USF
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4FW2
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6TOQ
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6U8Q
| CryoEM structure of HIV-1 cleaved synaptic complex (CSC) intasome | 分子名称: | (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ... | 著者 | Li, M, Chen, X, Craigie, R. | 登録日 | 2019-09-05 | 公開日 | 2020-02-05 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4.67 Å) | 主引用文献 | A Peptide Derived from Lens Epithelium-Derived Growth Factor Stimulates HIV-1 DNA Integration and Facilitates Intasome Structural Studies. J.Mol.Biol., 432, 2020
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7JN3
| Cryo-EM structure of Rous sarcoma virus cleaved synaptic complex (CSC) with HIV-1 integrase strand transfer inhibitor MK-2048 | 分子名称: | (6S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*GP*CP*AP*TP*AP*AP*GP*AP*CP*AP*AP*CP*A)-3'), ... | 著者 | Pandey, K.K, Bera, S, Shi, K, Aihara, H, Grandgenett, D.P. | 登録日 | 2020-08-03 | 公開日 | 2021-03-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome. Commun Biol, 4, 2021
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6V3K
| Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ419 (compound 4c) | 分子名称: | 4-azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-(5-oxidanylpentyl)-1,8-naphthyridine-3-carboxamide, Chimeric Sso7d and HIV-1 integrase, MAGNESIUM ION, ... | 著者 | Lyumkis, D, Jozwik, I.K, Passos, D. | 登録日 | 2019-11-25 | 公開日 | 2020-02-12 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis for strand-transfer inhibitor binding to HIV intasomes. Science, 367, 2020
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7KUI
| Cryo-EM structure of Rous sarcoma virus cleaved synaptic complex (CSC) with HIV-1 integrase strand transfer inhibitor MK-2048. CIC region of a cluster identified by 3-dimensional variability analysis in cryoSPARC. | 分子名称: | (6S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*GP*CP*AP*TP*AP*AP*GP*AP*CP*AP*AP*CP*A)-3'), ... | 著者 | Pandey, K.K, Bera, S, Shi, K, Aihara, H, Grandgenett, D.P. | 登録日 | 2020-11-25 | 公開日 | 2021-03-17 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome. Commun Biol, 4, 2021
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7KU7
| Cryo-EM structure of Rous sarcoma virus cleaved synaptic complex (CSC) with HIV-1 integrase strand transfer inhibitor MK-2048. Cluster identified by 3-dimensional variability analysis in cryoSPARC. | 分子名称: | (6S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*GP*CP*AP*TP*AP*AP*GP*AP*CP*AP*AP*CP*A)-3'), ... | 著者 | Pandey, K.K, Bera, S, Shi, K, Aihara, H, Grandgenett, D.P. | 登録日 | 2020-11-24 | 公開日 | 2021-03-17 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome. Commun Biol, 4, 2021
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