6V3K

Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ419 (compound 4c)

Summary for 6V3K

Entry DOI	10.2210/pdb6v3k/pdb
EMDB information	21038
Descriptor	Chimeric Sso7d and HIV-1 integrase, viral DNA non-transferred strand, viral DNA transferred strand, ... (6 entities in total)
Functional Keywords	integrase, intasome, enzyme, transposition, viral protein-dna complex, viral protein/dna
Biological source	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) More
Total number of polymer chains	6
Total formula weight	185858.17
Authors	Lyumkis, D.,Jozwik, I.K.,Passos, D. (deposition date: 2019-11-25, release date: 2020-02-12, Last modification date: 2024-03-06)
Primary citation	Passos, D.O.,Li, M.,Jozwik, I.K.,Zhao, X.Z.,Santos-Martins, D.,Yang, R.,Smith, S.J.,Jeon, Y.,Forli, S.,Hughes, S.H.,Burke Jr., T.R.,Craigie, R.,Lyumkis, D. Structural basis for strand-transfer inhibitor binding to HIV intasomes. Science, 367:810-814, 2020 Cited by PubMed: 32001521 DOI: 10.1126/science.aay8015 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation