6V3K
Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ419 (compound 4c)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Chimeric Sso7d and HIV-1 integrase | polymer | 383 | 42321.3 | 4 | UniProt (P39476) UniProt (Q76353) Pfam (PF02294) Pfam (PF02022) Pfam (PF00665) Pfam (PF00552) UniProt (by SIFTS) (P12497) | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) | 7 kDa DNA-binding protein d,Sso7d |
| 2 | E (E) | viral DNA non-transferred strand | polymer | 27 | 8188.3 | 1 | Human immunodeficiency virus 1 | ||
| 3 | F (F) | viral DNA transferred strand | polymer | 25 | 7773.0 | 1 | Human immunodeficiency virus 1 | ||
| 4 | G, H (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | I, K (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | J (A) | 4-azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-(5-oxidanylpentyl)-1,8-naphthyridine-3-carboxamide | non-polymer | 432.4 | 1 | Chemie (QUW) |
Sequence modifications
A, B, C, D: -74 - -11 (UniProt: P39476)
A, B, C, D: 1 - 288 (UniProt: Q76353)
| PDB | External Database | Details |
|---|---|---|
| Met -94 | - | expression tag |
| Gly -93 | - | expression tag |
| Ser -92 | - | expression tag |
| Ser -91 | - | expression tag |
| His -90 | - | expression tag |
| His -89 | - | expression tag |
| His -88 | - | expression tag |
| His -87 | - | expression tag |
| His -86 | - | expression tag |
| His -85 | - | expression tag |
| Ser -84 | - | expression tag |
| Ser -83 | - | expression tag |
| Gly -82 | - | expression tag |
| Leu -81 | - | expression tag |
| Val -80 | - | expression tag |
| Pro -79 | - | expression tag |
| Arg -78 | - | expression tag |
| Gly -77 | - | expression tag |
| Ser -76 | - | expression tag |
| His -75 | - | expression tag |
| Gly -10 | - | linker |
| Gly -9 | - | linker |
| Gly -8 | - | linker |
| Gly -7 | - | linker |
| Gly -6 | - | linker |
| Gly -5 | - | linker |
| Gly -4 | - | linker |
| Gly -3 | - | linker |
| Gly -2 | - | linker |
| Gly -1 | - | linker |
| Gly 0 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 185246.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 611.8 | |
| All* | Total formula weight | 185858.2 |
