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PDB: 292 件
3RZX
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BU of 3rzx by Molmil
Mouse importin alpha-Ku70 NLS peptide complex
分子名称: Importin subunit alpha-2, Ku70 NLS peptide
著者Takeda, A.A.S, Fontes, M.R.M.
登録日2011-05-12
公開日2011-08-03
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Structural basis of importin-alpha-mediated nuclear transport for Ku70 and Ku80.
J.Mol.Biol., 412, 2011
3RZ9
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BU of 3rz9 by Molmil
Mouse importin alpha-Ku80 NLS peptide complex
分子名称: Importin subunit alpha-2, Ku80 NLS peptide
著者Barros, A.C, Takeda, A.A.S, Fontes, M.R.M.
登録日2011-05-11
公開日2011-08-03
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Structural basis of importin-alpha-mediated nuclear transport for Ku70 and Ku80.
J.Mol.Biol., 412, 2011
3SL9
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BU of 3sl9 by Molmil
X-ray structure of Beta catenin in complex with Bcl9
分子名称: 1,2-ETHANEDIOL, B-cell CLL/lymphoma 9 protein, Catenin beta-1, ...
著者Gupta, D, Bienz, M.
登録日2011-06-24
公開日2012-02-29
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献An intrinsically labile alpha-helix abutting the BCL9-binding site of beta-catenin is required for its inhibition by carnosic acid.
Nat Commun, 3, 2012
7F6M
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BU of 7f6m by Molmil
Crystal structure of APC complexed with a peptide inhibitor MAI-516
分子名称: Adenomatous polyposis coli protein, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Song, K, Zhang, J.
登録日2021-06-25
公開日2022-06-29
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery of Efficient Adenomatous Polyposis Coli - Rho Guanine Nucleotide Exchange Factor 4 Inhibitors by Employing High Binding Affinity Tracer
To Be Published
5VQI
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BU of 5vqi by Molmil
Nuclear transport of the Neurospora crassa NIT2 transcription factor is mediated by Importin-alpha
分子名称: Importin subunit alpha, Nuclear localization sequence of NIT2 transcription factor (NIT2-NLS)
著者Bernardes, N.E, Fontes, M.R.M.
登録日2017-05-09
公開日2017-11-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Nuclear transport of the Neurospora crassa NIT-2 transcription factor is mediated by importin-alpha.
Biochem. J., 474, 2017
5W4F
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BU of 5w4f by Molmil
Importin binding to pol Mu NLS peptide
分子名称: DNA-directed DNA/RNA polymerase mu, GLYCEROL, Importin subunit alpha-1
著者Pedersen, L.C, London, R.E.
登録日2017-06-10
公開日2018-06-13
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.984 Å)
主引用文献Variations in nuclear localization strategies among pol X family enzymes.
Traffic, 2018
7F7O
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BU of 7f7o by Molmil
APC-Asef FP assay tracer
分子名称: Adenomatous polyposis coli protein, N-[3',6'-bis(oxidanyl)-3-oxidanylidene-spiro[2-benzofuran-1,9'-xanthene]-5-yl]methanethioamide, Tracer 7
著者Yang, X, Zhang, J.
登録日2021-06-30
公開日2022-07-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The tracer of FP assay for screening APC-Asef inhbitors
To Be Published
5W4G
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BU of 5w4g by Molmil
Importin binding to NLS peptide of DNA polymerase lambda
分子名称: DNA polymerase lambda, GLYCEROL, Importin subunit alpha-1, ...
著者Pedersen, L.C, London, R.E.
登録日2017-06-10
公開日2018-06-13
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.038 Å)
主引用文献Structure of Importin with bound NLS from DNA polymerase lambda
To Be Published
5W41
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BU of 5w41 by Molmil
Zika MR766 NLS in complex with Importin alpha subunit-1
分子名称: Importin subunit alpha-1, ZIKA MR766 NLS
著者Jeffress, S, Smith, K.M, Forwood, J.K.
登録日2017-06-08
公開日2018-06-13
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Zika virus NS5 forms supramolecular nuclear bodies that sequester importin alpha and modulate the host immune and pro-inflammatory response in neuronal cells.
ACS Infect Dis, 2019
5W4E
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BU of 5w4e by Molmil
Importin binding to Tdt NLS peptide
分子名称: GLYCEROL, Importin subunit alpha-1,Importin subunit alpha-1, human DNA repair polymerase Tdt
著者Pedersen, L.C, London, R.
登録日2017-06-10
公開日2018-06-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Variations in nuclear localization strategies among pol X family enzymes.
Traffic, 2018
5WUN
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BU of 5wun by Molmil
Crystal structure of mouse importin-alpha1 bound to non-phosphorylated NLS of EBNA1
分子名称: Epstein-Barr nuclear antigen 1, Importin subunit alpha-1
著者Nakada, R, Hirano, H, Matsuura, Y.
登録日2016-12-19
公開日2017-01-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for the regulation of nuclear import of Epstein-Barr virus nuclear antigen 1 (EBNA1) by phosphorylation of the nuclear localization signal.
Biochem. Biophys. Res. Commun., 484, 2017
5WUM
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BU of 5wum by Molmil
Crystal structure of mouse importin-alpha1 bound to S385-phosphorylated NLS of EBNA1
分子名称: Epstein-Barr nuclear antigen 1, Importin subunit alpha-1
著者Nakada, R, Hirano, H, Matsuura, Y.
登録日2016-12-19
公開日2017-01-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for the regulation of nuclear import of Epstein-Barr virus nuclear antigen 1 (EBNA1) by phosphorylation of the nuclear localization signal.
Biochem. Biophys. Res. Commun., 484, 2017
7JJM
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BU of 7jjm by Molmil
Crystal structure of Importin alpha 2 in complex with LSD1 NLS
分子名称: CHLORIDE ION, Importin subunit alpha-1, Lysine-specific histone demethylase 1A
著者Tu, W.J, McGuaig, R, Tan, H.Y.A, Hardy, C, Seddiki, N, Ali, S, Dahlstrom, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K.M, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S.
登録日2020-07-27
公開日2020-08-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
7JJL
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BU of 7jjl by Molmil
Crystal structure of Importin Alpha 3 in complex with human LSD1 NLS
分子名称: Importin subunit alpha-3, Lysine-specific histone demethylase 1A
著者Tu, W.J, McCuaig, R, Tan, H.Y.A, Hardy, K, Seddiki, N, Ali, S, Dahlstrom, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S.
登録日2020-07-27
公開日2020-08-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
7JK7
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BU of 7jk7 by Molmil
Crystal structure of Importin alpha 2 in complex with LSD1 NLS S111E mutant
分子名称: GLYCEROL, Importin subunit alpha-1, Lysine-specific histone demethylase 1A
著者Tu, W.J, McCuaig, R, Tan, A.H.Y, Hardy, K, Seddiki, N, Ali, S, Dahlstron, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K.M, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S.
登録日2020-07-27
公開日2020-08-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
5X8N
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BU of 5x8n by Molmil
Crystal structure of mouse importin-alpha1 bound to the nuclear localization signal of Epstein-Barr virus EBNA-LP protein
分子名称: Epstein-Barr nuclear antigen leader protein, Importin subunit alpha-1
著者Nakada, R, Matsuura, Y.
登録日2017-03-03
公開日2017-04-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal structure of importin-alpha bound to the nuclear localization signal of Epstein-Barr virus EBNA-LP protein
Protein Sci., 26, 2017
7JVO
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BU of 7jvo by Molmil
Importin alpha bound to the C-terminus of ACE2
分子名称: ARG-LYS-LYS-LYS-ASN-LYS-ALA, Importin subunit alpha-1
著者Forwood, J.K, Cross, E.M, Tsimbalyuk, S.
登録日2020-08-22
公開日2020-10-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication.
Cell Discov, 7, 2021
5XZX
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BU of 5xzx by Molmil
Crystal structure of importin-alpha3 bound to the nuclear localization signal of Ran-binding protein 3
分子名称: Importin subunit alpha-3, Ran-binding protein 3
著者Koyama, M, Matsuura, Y.
登録日2017-07-14
公開日2017-08-09
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of importin-alpha 3 bound to the nuclear localization signal of Ran-binding protein 3
Biochem. Biophys. Res. Commun., 491, 2017
7L04
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BU of 7l04 by Molmil
Crystal Structure of Adeno-Associated Virus Porcine Origin capsid protein in complex with Importin-alpha 2
分子名称: Importin subunit alpha-1, VP1
著者Hoad, M, Forwood, J.
登録日2020-12-11
公開日2021-02-24
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Crystal Structure of Adeno-Associated Virus Porcine Origin capsid protein in complex with Importin-alpha 2
To Be Published
5Z8H
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BU of 5z8h by Molmil
APC with an inhibitor
分子名称: Adenomatous polyposis coli protein, GLYCEROL, Peptide inhibitor
著者Zhang, J, Yang, X.Y, Song, K.
登録日2018-01-31
公開日2019-02-06
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献APC with an inhibitor
To Be Published
7LEU
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BU of 7leu by Molmil
Structure of importin a2 bound to p65-NLS
分子名称: Importin subunit alpha-1, Transcription factor p65
著者Florio, T.J, Lokareddy, R.K, Cingolani, G.
登録日2021-01-15
公開日2022-01-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Differential recognition of canonical NF-kappa B dimers by Importin alpha 3.
Nat Commun, 13, 2022
7LFC
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BU of 7lfc by Molmil
Structure of importin a3 bound to p50 NLS
分子名称: Importin subunit alpha-3, Nuclear factor NF-kappa-B p105 subunit
著者Florio, T.J, Lokareddy, R.K, Cingolani, G.
登録日2021-01-16
公開日2022-01-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Differential recognition of canonical NF-kappa B dimers by Importin alpha 3.
Nat Commun, 13, 2022
7LEQ
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BU of 7leq by Molmil
Structure of importin a2 bound to p50 NLS
分子名称: Importin subunit alpha-1, Nuclear factor NF-kappa-B p105 subunit
著者Florio, T.J, Lokareddy, R.K, Cingolani, G.
登録日2021-01-14
公開日2022-01-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Differential recognition of canonical NF-kappa B dimers by Importin alpha 3.
Nat Commun, 13, 2022
7LET
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BU of 7let by Molmil
Structure of importin a2 bound to the p50- and p65-NLSs
分子名称: Importin subunit alpha-1, Nuclear factor NF-kappa-B p105 subunit, Transcription factor p65
著者Florio, T.J, Lokareddy, R.K, Cingolani, G.
登録日2021-01-15
公開日2022-01-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Differential recognition of canonical NF-kappa B dimers by Importin alpha 3.
Nat Commun, 13, 2022
7LF4
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BU of 7lf4 by Molmil
Structure of importin a3 bound to the p50- and p65-NLSs
分子名称: Importin subunit alpha-3, Nuclear factor NF-kappa-B p105 subunit, Transcription factor p65
著者Florio, T.J, Lokareddy, R.K, Cingolani, G.
登録日2021-01-15
公開日2022-01-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Differential recognition of canonical NF-kappa B dimers by Importin alpha 3.
Nat Commun, 13, 2022

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件を2024-06-05に公開中

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