Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 414 件
6DCN
DownloadVisualize
BU of 6dcn by Molmil
Bcl-xL complex with Beclin 1 BH3 domain T108pThr
分子名称: BCL-xl protein, Beclin-1
著者Lee, E.F, Smith, B.J, Smith, N.A, Yao, S, Fairlie, W.D.
登録日2018-05-07
公開日2018-05-23
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.444 Å)
主引用文献Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1.
Autophagy, 15, 2019
4PPI
DownloadVisualize
BU of 4ppi by Molmil
Crystal structure of Bcl-xL hexamer
分子名称: Bcl-2-like protein 1, GLYCEROL
著者Sreekanth, R, Yoon, H.S.
登録日2014-02-27
公開日2015-03-04
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.851 Å)
主引用文献Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport
Sci Rep, 5, 2015
4QVE
DownloadVisualize
BU of 4qve by Molmil
Crystal structure of Bcl-xL in complex with BID BH3 domain
分子名称: Bcl-2-like protein 1, IMIDAZOLE, Peptide from BH3-interacting domain death agonist
著者Sreekanth, R, Yoon, H.S.
登録日2014-07-14
公開日2015-06-10
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Bh3 induced conformational changes in Bcl-Xl revealed by crystal structure and comparative analysis.
Proteins, 83, 2015
4QNQ
DownloadVisualize
BU of 4qnq by Molmil
Crystal Structure Analysis of full-length Bcl-XL in complex with the inhibitor ABT-263
分子名称: 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide, Bcl-2-like protein 1
著者Korste, A, Vetter, I.R, Stoll, R.
登録日2014-06-18
公開日2015-10-28
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure Analysis of full-length Bcl-XL in complex with the inhibitor ABT-263
TO BE PUBLISHED
4QVX
DownloadVisualize
BU of 4qvx by Molmil
Discovery of a Potent and Selective BCL-XL Inhibitor That Demonstrates Thrombocytopenia and Inhibits Tumor Growth in Vivo
分子名称: 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-5-(3-{4-[3-(dimethylamino)prop-1-yn-1-yl]-2-fluorophenoxy}propyl)-1,3-thiazole-4-carboxylic acid, Bcl-2-like protein 1
著者Park, C.H.
登録日2014-07-16
公開日2015-07-22
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
ACS MED.CHEM.LETT., 5, 2014
1R2G
DownloadVisualize
BU of 1r2g by Molmil
Human Bcl-XL containing a Phe to Trp mutation at position 97
分子名称: Apoptosis regulator Bcl-X
著者O'Neill, J.W, Manion, M.K, Giedt, C.D, Kim, K.M, Zhang, K.Y, Hockenbery, D.M.
登録日2003-09-26
公開日2004-02-03
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Bcl-XL mutations suppress cellular sensitivity to antimycin A.
J.Biol.Chem., 279, 2004
1R2E
DownloadVisualize
BU of 1r2e by Molmil
Human Bcl-XL containing a Glu to Leu mutation at position 92
分子名称: Apoptosis regulator Bcl-X
著者O'Neill, J.W, Manion, M.K, Giedt, C.D, Kim, K.M, Zhang, K.Y, Hockenbery, D.M.
登録日2003-09-26
公開日2004-02-03
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Bcl-XL mutations suppress cellular sensitivity to antimycin A.
J.Biol.Chem., 279, 2004
1R2I
DownloadVisualize
BU of 1r2i by Molmil
Human Bcl-XL containing a Phe to Leu mutation at position 146
分子名称: Apoptosis regulator Bcl-X
著者O'Neill, J.W, Manion, M.K, Giedt, C.D, Kim, K.M, Zhang, K.Y, Hockenbery, D.M.
登録日2003-09-26
公開日2004-02-03
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Bcl-XL mutations suppress cellular sensitivity to antimycin A.
J.Biol.Chem., 279, 2004
7XGF
DownloadVisualize
BU of 7xgf by Molmil
Crystal structure of BCL-xL in complex with computationally designed inhibitor protein
分子名称: BCL-xL, BCL-xL and MCL-1 dual inhibitor 2
著者Oh, B.-H, Kim, S.
登録日2022-04-04
公開日2022-07-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Computational design of an apoptogenic protein that binds BCL-xL and MCL-1 simultaneously and potently.
Comput Struct Biotechnol J, 20, 2022
7XGG
DownloadVisualize
BU of 7xgg by Molmil
Crystal structure of BCL-xL in complex with computationally designed inhibitor protein
分子名称: BCL-xL and MCL-1 dual inhibitor, Bcl-2-like protein 1
著者Oh, B.-H, Kim, S.
登録日2022-04-04
公開日2022-07-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Computational design of an apoptogenic protein that binds BCL-xL and MCL-1 simultaneously and potently.
Comput Struct Biotechnol J, 20, 2022
7WJH
DownloadVisualize
BU of 7wjh by Molmil
Crystal structure of Bcl-xL bound to the BH3 domain of human Pxt1
分子名称: Bcl-2-like protein 1, MAGNESIUM ION, Peroxisomal testis-specific protein 1, ...
著者Lim, D, Ku, B.
登録日2022-01-06
公開日2022-09-14
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.698 Å)
主引用文献Structural and biochemical analyses of Bcl-xL in complex with the BH3 domain of peroxisomal testis-specific 1.
Biochem.Biophys.Res.Commun., 625, 2022
3ZK6
DownloadVisualize
BU of 3zk6 by Molmil
Crystal structure of Bcl-xL in complex with inhibitor (Compound 2).
分子名称: BCL-2-LIKE PROTEIN 1, N-(3-(5-(1-(2-(benzo[d]thiazol-2-yl)hydrazono)ethyl)furan-2-yl)phenylsulfonyl)-6-phenylhexanamide
著者Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M.
登録日2013-01-22
公開日2013-04-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
3WIZ
DownloadVisualize
BU of 3wiz by Molmil
Crystal structure of Bcl-xL in complex with compound 10
分子名称: 7-(4-{[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]carbamoyl}-2-methylphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid, Bcl-2-like protein 1, PHOSPHATE ION
著者Sogabe, S, Igaki, S, Hayano, Y.
登録日2013-09-26
公開日2013-11-27
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
J.Med.Chem., 56, 2013
3ZLO
DownloadVisualize
BU of 3zlo by Molmil
Crystal structure of BCL-XL in complex with inhibitor (Compound 6)
分子名称: 2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-5-(4-phenylbutyl)-1,3-thiazole-4-carboxylic acid, BCL-2-LIKE PROTEIN 1
著者Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M.
登録日2013-02-04
公開日2013-04-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.601 Å)
主引用文献Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
3ZLR
DownloadVisualize
BU of 3zlr by Molmil
Crystal structure of BCL-XL in complex with inhibitor (WEHI-539)
分子名称: 1,2-ETHANEDIOL, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid, BCL-2-LIKE PROTEIN 1, ...
著者Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M.
登録日2013-02-04
公開日2013-04-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.026 Å)
主引用文献Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
3ZLN
DownloadVisualize
BU of 3zln by Molmil
Crystal structure of BCL-XL in complex with inhibitor (Compound 3)
分子名称: 1,2-ETHANEDIOL, 6-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]pyridine-2-carboxylic acid, BCL-2-LIKE PROTEIN 1, ...
著者Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M.
登録日2013-02-04
公開日2013-04-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.288 Å)
主引用文献Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
4AQ3
DownloadVisualize
BU of 4aq3 by Molmil
HUMAN BCL-2 WITH PHENYLACYLSULFONAMIDE INHIBITOR
分子名称: APOPTOSIS REGULATOR BCL-2, BCL-2-LIKE PROTEIN 1, N,N-dibutyl-4-chloranyl-1-[2-(3,4-dihydro-1H-isoquinolin-2-ylcarbonyl)-4-[(7-iodanylnaphthalen-2-yl)sulfonylcarbamoyl]phenyl]-5-methyl-pyrazole-3-carboxamide
著者Bertrand, J.A, Fasolini, M, Modugno, M.
登録日2012-04-12
公開日2012-06-06
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Identification of a Phenylacylsulfonamide Series of Dual Bcl-2/Bcl-Xl Antagonists.
Bioorg.Med.Chem.Lett., 22, 2012
4A1U
DownloadVisualize
BU of 4a1u by Molmil
Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL
分子名称: ALPHA-BETA-FOLDAMER 2C, BCL-2-LIKE PROTEIN 1, CHLORIDE ION, ...
著者Boersma, M.D, Haase, H.S, Kaufman, K.J, Horne, W.S, Lee, E.F, Clarke, O.B, Smith, B.J, Colman, P.M, Gellman, S.H, Fairlie, W.D.
登録日2011-09-20
公開日2011-12-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain.
J.Am.Chem.Soc., 134, 2012
4A1W
DownloadVisualize
BU of 4a1w by Molmil
Crystal structure of alpha-beta foldamer 4c in complex with Bcl-xL
分子名称: ALPHA-BETA-FOLDAMER 2C, BCL-2-LIKE PROTEIN 1
著者Boersma, M.D, Haase, H.S, Kaufman, K.J, Horne, W.S, Lee, E.F, Clarke, O.B, Smith, B.J, Colman, P.M, Gellman, S.H, Fairlie, W.D.
登録日2011-09-20
公開日2011-12-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.497 Å)
主引用文献Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain.
J.Am.Chem.Soc., 134, 2012
7Y99
DownloadVisualize
BU of 7y99 by Molmil
Crystal Structure Analysis of cp2 bound BCLxl
分子名称: Bcl-2-like protein 1, CP2 peptide, N-(2-acetamidoethyl)-4-(4,5-dihydro-1,3-thiazol-2-yl)benzamide
著者Li, F.W, Liu, C, Wu, C.L, Wu, D.L.
登録日2022-06-24
公開日2023-09-27
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.
Nat Commun, 15, 2024
7Y8D
DownloadVisualize
BU of 7y8d by Molmil
Crystal structure of cp1 bound BCLxl
分子名称: (2R)-3-[2-(aminomethyl)-3-azanyl-1-[4-[2-(2-chloranylethanoylamino)ethylcarbamoyl]phenyl]prop-1-enyl]sulfanyl-2-(carboxyamino)propanoic acid, Bcl-2-like protein 1, cp1 peptide
著者Li, F.W, Liu, C, Wu, C.L, Wu, D.L.
登録日2022-06-23
公開日2023-11-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.
Nat Commun, 15, 2024
7YB7
DownloadVisualize
BU of 7yb7 by Molmil
anti-apoptotic protein BCL-2-M12
分子名称: Apoptosis regulator Bcl-2,Bcl-2-like protein 1, N-(2-acetamidoethyl)-4-(4,5-dihydro-1,3-thiazol-2-yl)benzamide, cp2 peptide
著者Li, F.W, Liu, C, Wu, D.L.
登録日2022-06-29
公開日2023-11-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.
Nat Commun, 15, 2024
7YA5
DownloadVisualize
BU of 7ya5 by Molmil
Crystal structure analysis of cp1 bound BCL2/G101V
分子名称: (2R)-3-[2-(aminomethyl)-3-azanyl-1-[4-[2-(2-chloranylethanoylamino)ethylcarbamoyl]phenyl]prop-1-enyl]sulfanyl-2-(carboxyamino)propanoic acid, Apoptosis regulator Bcl-2, cp1 peptide
著者Li, F.W, Liu, C, Wu, C.L, Wu, D.L.
登録日2022-06-27
公開日2023-11-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.
Nat Commun, 15, 2024
7Y90
DownloadVisualize
BU of 7y90 by Molmil
Crystal Structure Analysis of cp1 bound BCL2
分子名称: (2R)-3-[2-(aminomethyl)-3-azanyl-1-[4-[2-(2-chloranylethanoylamino)ethylcarbamoyl]phenyl]prop-1-enyl]sulfanyl-2-(carboxyamino)propanoic acid, Apoptosis regulator Bcl-2, cp1 peptide
著者Li, F.W.
登録日2022-06-24
公開日2023-11-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.
Nat Commun, 15, 2024
7YAA
DownloadVisualize
BU of 7yaa by Molmil
Crystal structure analysis of cp3 bound BCLxl
分子名称: Bcl-2-like protein 1, GLYCEROL, N-(2-acetamidoethyl)-4-(4-methanoyl-1,3-thiazol-2-yl)benzamide, ...
著者Li, F.W, Liu, C, Wu, C.L, Wu, D.L.
登録日2022-06-27
公開日2023-11-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.
Nat Commun, 15, 2024

221051

件を2024-06-12に公開中

PDB statisticsPDBj update infoContact PDBjnumon