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PDB: 113 件

3U9T
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Crystal structure of P. aeruginosa 3-methylcrotonyl-CoA carboxylase (MCC) 750 kD holoenzyme, free enzyme
分子名称: Methylcrotonyl-CoA carboxylase, alpha-subunit, beta-subunit
著者Huang, C.S, Tong, L.
登録日2011-10-19
公開日2011-12-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献An unanticipated architecture of the 750-kDa {alpha}6{beta}6 holoenzyme of 3-methylcrotonyl-CoA carboxylase
Nature, 481, 2012
3JZF
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Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazoles series
分子名称: 2-[(2-chlorobenzyl)amino]-1-(cyclohexylmethyl)-1H-benzimidazole-5-carboxamide, Biotin carboxylase, CARBONATE ION
著者Orth, P.
登録日2009-09-23
公開日2009-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Discovery and optimization of antibacterial AccC inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
3JRW
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Phosphorylated BC domain of ACC2
分子名称: Acetyl-CoA carboxylase 2
著者Cho, Y.S, Lee, J.I, Shin, D, Kim, H.T, Lee, T.G, Heo, Y.S.
登録日2009-09-09
公開日2010-01-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK
Biochem.Biophys.Res.Commun., 391, 2010
3JRX
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Crystal structure of the BC domain of ACC2 in complex with soraphen A
分子名称: Acetyl-CoA carboxylase 2, SORAPHEN A
著者Cho, Y.S, Lee, J.I, Shin, D, Kim, H.T, Lee, T.G, Heo, Y.S.
登録日2009-09-09
公開日2010-01-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK.
Biochem.Biophys.Res.Commun., 391, 2010
3OUU
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Crystal Structure of Biotin Carboxylase-beta-gamma-ATP Complex from Campylobacter jejuni
分子名称: Biotin carboxylase, CACODYLATE ION, CALCIUM ION, ...
著者Maltseva, N, Kim, Y, Makowska-Grzyska, M, Mulligan, R, Papazisi, L, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2010-09-15
公開日2010-10-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.252 Å)
主引用文献Crystal Structure of Biotin Carboxylase-beta-gamma-ATP Complex from Campylobacter jejuni
TO BE PUBLISHED
3JZI
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Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series
分子名称: 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide, Biotin carboxylase
著者Cheng, C, Shipps, G.W, Yang, Z, Sun, B, Kawahata, N, Soucy, K, Soriano, A, Orth, P, Xiao, L, Mann, P, Black, T.
登録日2009-09-23
公開日2009-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Discovery and optimization of antibacterial AccC inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
3U9S
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Crystal structure of P. aeruginosa 3-methylcrotonyl-CoA carboxylase (MCC) 750 kD holoenzyme, CoA complex
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Methylcrotonyl-CoA carboxylase, ...
著者Huang, C.S, Tong, L.
登録日2011-10-19
公開日2011-12-14
最終更新日2013-01-23
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献An unanticipated architecture of the 750-kDa {alpha}6{beta}6 holoenzyme of 3-methylcrotonyl-CoA carboxylase
Nature, 481, 2012
3TW7
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Structure of Rhizobium etli pyruvate carboxylase T882A crystallized without acetyl coenzyme-A
分子名称: CHLORIDE ION, MAGNESIUM ION, Pyruvate carboxylase protein, ...
著者St Maurice, M, Kumar, S, Lietzan, A.D.
登録日2011-09-21
公開日2011-10-12
最終更新日2011-12-28
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Interaction between the biotin carboxyl carrier domain and the biotin carboxylase domain in pyruvate carboxylase from Rhizobium etli.
Biochemistry, 50, 2011
3TW6
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Structure of Rhizobium etli pyruvate carboxylase T882A with the allosteric activator, acetyl coenzyme-A
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
著者St Maurice, M, Kumar, S, Lietzan, A.D.
登録日2011-09-21
公開日2011-10-19
最終更新日2011-12-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Interaction between the biotin carboxyl carrier domain and the biotin carboxylase domain in pyruvate carboxylase from Rhizobium etli.
Biochemistry, 50, 2011
4HR7
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Crystal Structure of Biotin Carboxyl Carrier Protein-Biotin Carboxylase Complex from E.coli
分子名称: 1,2-ETHANEDIOL, Biotin carboxyl carrier protein of acetyl-CoA carboxylase, Biotin carboxylase, ...
著者Broussard, T.C, Kobe, M.J, Pakhomova, S, Neau, D.B, Price, A.E, Champion, T.S, Waldrop, G.L.
登録日2012-10-26
公開日2013-03-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.495 Å)
主引用文献The three-dimensional structure of the biotin carboxylase-biotin carboxyl carrier protein complex of E. coli acetyl-CoA carboxylase.
Structure, 21, 2013
3N6R
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CRYSTAL STRUCTURE OF the holoenzyme of PROPIONYL-COA CARBOXYLASE (PCC)
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Propionyl-CoA carboxylase, alpha subunit, ...
著者Huang, C.S, Sadre-Bazzaz, K, Tong, L.
登録日2010-05-26
公開日2010-08-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structure of the alpha(6)beta(6) holoenzyme of propionyl-coenzyme A carboxylase.
Nature, 466, 2010
4HNT
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crystal structure of F403A mutant of S. aureus Pyruvate carboxylase
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Yu, L.P.C, Tong, L.
登録日2012-10-21
公開日2013-01-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis.
Biochemistry, 52, 2013
4HQ6
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BC domain in the presence of citrate
分子名称: Acetyl-CoA carboxylase 2
著者Heo, Y.S.
登録日2012-10-25
公開日2013-10-09
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Insights into the Regulation of ACC2 by Citrate
Bull.Korean Chem.Soc., 34, 2013
4HNU
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crystal structure of K442E mutant of S. aureus Pyruvate carboxylase
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
著者Yu, L.P.C, Tong, L.
登録日2012-10-21
公開日2013-01-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis.
Biochemistry, 52, 2013
4HNV
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Crystal structure of R54E mutant of S. aureus Pyruvate carboxylase
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Yu, L.P.C, Tong, L.
登録日2012-10-21
公開日2013-01-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis.
Biochemistry, 52, 2013
3OUZ
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Crystal Structure of Biotin Carboxylase-ADP complex from Campylobacter jejuni
分子名称: ADENOSINE-5'-DIPHOSPHATE, Biotin carboxylase, D-MALATE, ...
著者Maltseva, N, Kim, Y, Makowska-Grzyska, M, Mulligan, R, Papazisi, L, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2010-09-15
公開日2010-10-13
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.902 Å)
主引用文献Crystal Structure of Biotin Carboxylase-ADP complex from Campylobacter jejuni
TO BE PUBLISHED
3VA7
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Crystal structure of the Kluyveromyces lactis Urea Carboxylase
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, GLYCEROL, KLLA0E08119p, ...
著者Fan, C, Xiang, S.
登録日2011-12-29
公開日2012-02-01
最終更新日2013-07-17
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of urea carboxylase provides insights into the carboxyltransfer reaction
J.Biol.Chem., 287, 2012
3RUP
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Crystal structure of E.coli biotin carboxylase in complex with two ADP and two Ca ions
分子名称: ADENOSINE-5'-DIPHOSPHATE, Biotin carboxylase, CALCIUM ION, ...
著者Chou, C.Y, Tong, L.
登録日2011-05-05
公開日2011-05-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Structural and biochemical studies on the regulation of biotin carboxylase by substrate inhibition and dimerization.
J.Biol.Chem., 286, 2011
3RV4
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Crystal structure of E.coli biotin carboxylase R16E mutant in complex with Mg-ADP and bicarbonate
分子名称: ADENOSINE-5'-DIPHOSPHATE, BICARBONATE ION, Biotin carboxylase, ...
著者Chou, C.Y, Tong, L.
登録日2011-05-05
公開日2011-05-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Structural and biochemical studies on the regulation of biotin carboxylase by substrate inhibition and dimerization.
J.Biol.Chem., 286, 2011
3RV3
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Crystal structure of E.coli biotin carboxylase in complex with two ADP and one Mg ion
分子名称: ADENOSINE-5'-DIPHOSPHATE, Biotin carboxylase, MAGNESIUM ION
著者Chou, C.Y, Tong, L.
登録日2011-05-05
公開日2011-05-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Structural and biochemical studies on the regulation of biotin carboxylase by substrate inhibition and dimerization.
J.Biol.Chem., 286, 2011
7WTD
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Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 1
分子名称: ADENOSINE-5'-TRIPHOSPHATE, COENZYME A, Pyruvate carboxylase, ...
著者Chai, P, Lan, P, Wu, J, Lei, M.
登録日2022-02-04
公開日2022-11-09
最終更新日2022-11-16
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
7WTE
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Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 2
分子名称: ACETYL COENZYME *A, ADENOSINE-5'-TRIPHOSPHATE, Pyruvate carboxylase, ...
著者Chai, P, Lan, P, Wu, J, Lei, M.
登録日2022-02-04
公開日2022-11-09
最終更新日2022-11-16
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
7WTA
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Cryo-EM structure of human pyruvate carboxylase in apo state
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Pyruvate carboxylase, mitochondrial
著者Chai, P, Lan, P, Wu, J, Lei, M.
登録日2022-02-04
公開日2022-11-09
最終更新日2022-11-16
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
7WTC
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Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the ground state
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, Pyruvate carboxylase, ...
著者Chai, P, Lan, P, Wu, J, Lei, M.
登録日2022-02-04
公開日2022-11-09
最終更新日2022-11-16
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
7WTB
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Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Chai, P, Lan, P, Wu, J, Lei, M.
登録日2022-02-04
公開日2022-11-09
最終更新日2022-11-16
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022

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