6HUE
 
 | | ParkinS65N | | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase parkin, GLYCEROL, ... | | 著者 | McWilliams, T.G, Barini, E, Pohjolan-Pirhonen, R, Brooks, S.P, Singh, F, Burel, S, Balk, K, Kumar, A, Montava-Garriga, L, Prescott, A.R, Hassoun, S.M, Mouton-Liger, F, Ball, G, Hills, R, Knebel, A, Ulusoy, A, Di Monte, D.A, Tamjar, J, Antico, O, Fears, K, Smith, L, Brambilla, R, Palin, E, Valori, M, Eerola-Rautio, J, Tienari, P, Corti, O, Dunnett, S.B, Ganley, I.G, Suomalainen, A, Muqit, M.M.K. | | 登録日 | 2018-10-07 | | 公開日 | 2018-10-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Phosphorylation of Parkin at serine 65 is essential for its activation in vivo .
Open Biology, 8, 2018
|
|
6HEI
 | |
6I7Q
 | |
6JH1
 | |
6J62
 | |
6GLC
 | | Structure of phospho-Parkin bound to phospho-ubiquitin | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, E3 ubiquitin-protein ligase parkin, GLYCEROL, ... | | 著者 | Gladkova, C, Maslen, S.L, Skehel, J.M, Komander, D. | | 登録日 | 2018-05-23 | | 公開日 | 2018-06-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Mechanism of parkin activation by PINK1.
Nature, 559, 2018
|
|
6HR2
 | | Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB | | 分子名称: | (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... | | 著者 | Roy, M, Bader, G, Diers, E, Trainor, N, Farnaby, W, Ciulli, A. | | 登録日 | 2018-09-26 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
Nat.Chem.Biol., 15, 2019
|
|
6I7R
 | |
6HAY
 | | Crystal structure of PROTAC 1 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | | 分子名称: | (2~{S},4~{R})-~{N}-[[2-[2-[2-[2-[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Roy, M, Bader, G, Diers, E, Trainor, N, Farnaby, W, Ciulli, A. | | 登録日 | 2018-08-09 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
Nat.Chem.Biol., 15, 2019
|
|
6HIY
 | | Cryo-EM structure of the Trypanosoma brucei mitochondrial ribosome - This entry contains the body of the small mitoribosomal subunit in complex with mt-IF-3 | | 分子名称: | 9S rRNA, MAGNESIUM ION, SPERMIDINE, ... | | 著者 | Ramrath, D.J.F, Niemann, M, Leibundgut, M, Bieri, P, Prange, C, Horn, E.K, Leitner, A, Boehringer, D, Schneider, A, Ban, N. | | 登録日 | 2018-08-31 | | 公開日 | 2018-09-26 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
Science, 362, 2018
|
|
6HIW
 | | Cryo-EM structure of the Trypanosoma brucei mitochondrial ribosome - This entry contains the complete small mitoribosomal subunit in complex with mt-IF-3 | | 分子名称: | 9S rRNA, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Ramrath, D, Niemann, M, Leibundgut, M, Bieri, P, Prange, C, Horn, E.K, Leitner, A, Boehringer, D, Schneider, A, Ban, N. | | 登録日 | 2018-08-31 | | 公開日 | 2018-09-26 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | | 主引用文献 | Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
Science, 362, 2018
|
|
6GMR
 | | pVHL:EloB:EloC in complex with (4-(1H-pyrrol-1-yl)phenyl)methanol | | 分子名称: | (4-pyrrol-1-ylphenyl)methanol, Elongin-B, Elongin-C, ... | | 著者 | Van Molle, I, Lucas, X, Ciulli, A. | | 登録日 | 2018-05-28 | | 公開日 | 2018-08-08 | | 最終更新日 | 2018-09-05 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.
J. Med. Chem., 61, 2018
|
|
6HAX
 | | Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | | 分子名称: | (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Roy, M, Bader, G, Diers, E, Trainor, N, Farnaby, W, Ciulli, A. | | 登録日 | 2018-08-09 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
Nat.Chem.Biol., 15, 2019
|
|
6HEK
 | |
6GZS
 | |
6H4H
 | | Usp28 catalytic domain variant E593D in complex with UbPA | | 分子名称: | Polyubiquitin-B, SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 28, ... | | 著者 | Klemm, T.A, Sauer, F, Kisker, C. | | 登録日 | 2018-07-21 | | 公開日 | 2019-03-27 | | 最終更新日 | 2019-05-15 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Differential Oligomerization of the Deubiquitinases USP25 and USP28 Regulates Their Activities.
Mol.Cell, 74, 2019
|
|
6JWI
 | |
6ISU
 | | Crystal structure of Lys27-linked di-ubiquitin in complex with its selective interacting protein UCHL3 | | 分子名称: | Ubiquitin, Ubiquitin carboxyl-terminal hydrolase isozyme L3 | | 著者 | Ding, S, Pan, M, Zheng, Q, Ren, Y, Hong, D. | | 登録日 | 2018-11-19 | | 公開日 | 2019-02-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.866 Å) | | 主引用文献 | Chemical Protein Synthesis Enabled Mechanistic Studies on the Molecular Recognition of K27-linked Ubiquitin Chains.
Angew. Chem. Int. Ed. Engl., 58, 2019
|
|
6KBE
 | | Structure of Deubiquitinase | | 分子名称: | Polyubiquitin-C, Ubiquitin thioesterase | | 著者 | Lu, L.N, Liu, L, Wang, F. | | 登録日 | 2019-06-24 | | 公開日 | 2020-06-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.339 Å) | | 主引用文献 | Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains
Nat Commun, 13, 2022
|
|
6K9P
 | | Structure of Deubiquitinase | | 分子名称: | Ubiquitin, Ubiquitin thioesterase | | 著者 | Lu, L.N, Liu, L, Wang, F. | | 登録日 | 2019-06-17 | | 公開日 | 2020-06-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.047 Å) | | 主引用文献 | Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains
Nat Commun, 13, 2022
|
|
2LVO
 | | Structure of the gp78CUE domain bound to monubiquitin | | 分子名称: | E3 ubiquitin-protein ligase AMFR, Ubiquitin | | 著者 | Liu, S, Chen, Y, Huang, T, Tarasov, S.G, King, A, Li, J, Weissman, A.M, Byrd, R.A, Das, R. | | 登録日 | 2012-07-09 | | 公開日 | 2012-11-21 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Promiscuous Interactions of gp78 E3 Ligase CUE Domain with Polyubiquitin Chains.
Structure, 20, 2012
|
|
2JZ3
 | | SOCS box elonginBC ternary complex | | 分子名称: | Suppressor of cytokine signaling 3, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2 | | 著者 | Babon, J.J, Sabo, J, Soetopo, A, Yao, S, Bailey, M.F, Zhang, J, Nicola, N.A, Norton, R.S. | | 登録日 | 2007-12-27 | | 公開日 | 2008-09-23 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase
J.Mol.Biol., 381, 2008
|
|
5XBO
 | | Lanthanoid tagging via an unnatural amino acid for protein structure characterization | | 分子名称: | Polyubiquitin-B, TERBIUM(III) ION, UV excision repair protein RAD23 homolog A | | 著者 | Jiang, W, Gu, X, Dong, X, Tang, C. | | 登録日 | 2017-03-21 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Lanthanoid tagging via an unnatural amino acid for protein structure characterization
J. Biomol. NMR, 67, 2017
|
|
2JRI
 | | Solution structure of the Josephin domain of Ataxin-3 in complex with ubiquitin molecule. | | 分子名称: | Ataxin-3, UBC protein | | 著者 | Nicastro, G, Masino, L, Esposito, V, Menon, R, Pastore, A. | | 登録日 | 2007-06-27 | | 公開日 | 2008-07-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Understanding the plasticity of the ubiquitin-protein recognition code: the josephin domain of ataxin-3 is a diubiquitin binding motif
To be Published
|
|
5XU8
 | |
