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PDB: 244 件
6YYF
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BU of 6yyf by Molmil
Crystal Structure of 5-chloroindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
分子名称: 5-chloranyl-1,3-dihydroindol-2-one, MAGNESIUM ION, Tyrosine-protein kinase BTK, ...
著者Brear, P, Wagstaff, J, Hyvonen, M.
登録日2020-05-05
公開日2021-05-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Optimising crystallographic systems for structure-guided drug discovery
To Be Published
6YYG
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BU of 6yyg by Molmil
Crystal Structure of 5-(trifluoromethoxy)indoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
分子名称: 5-(trifluoromethyloxy)-1,3-dihydroindol-2-one, MAGNESIUM ION, Tyrosine-protein kinase BTK, ...
著者Brear, P, Wagstaff, J, Hyvonen, M.
登録日2020-05-05
公開日2021-05-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Optimising crystallographic systems for structure-guided drug discovery
To Be Published
4BBK
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BU of 4bbk by Molmil
Structural and functional characterisation of the kindlin-1 pleckstrin homology domain
分子名称: FERMITIN FAMILY HOMOLOG 1, GLYCEROL
著者Yates, L.A, Lumb, C.N, Brahme, N.N, Zalyte, R, Bird, L.E, De Colibus, L, Owens, R.J, Calderwood, D.A, Sansom, M.S.P, Gilbert, R.J.C.
登録日2012-09-25
公開日2012-11-14
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and Functional Characterisation of the Kindlin-1 Pleckstrin Homology Domain
J.Biol.Chem., 287, 2012
7AX3
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BU of 7ax3 by Molmil
CryoEM structure of the super-constricted two-start dynamin 1 filament
分子名称: Dynamin-1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
著者Liu, J.W, Zhang, P.J.
登録日2020-11-09
公開日2021-11-10
実験手法ELECTRON MICROSCOPY (3.74 Å)
主引用文献CryoEM structure of the super-constricted two-start dynamin 1 filament.
Nat Commun, 12, 2021
4CKH
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BU of 4ckh by Molmil
Helical reconstruction of ACAP1(BAR-PH domain) decorated membrane tubules by cryo-electron microscopy
分子名称: ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1
著者Pang, X.Y, Fan, J, Zhang, Y, Zhang, K, Gao, B.Q, Ma, J, Li, J, Deng, Y.C, Zhou, Q.J, Hsu, V, Sun, F.
登録日2014-01-06
公開日2014-10-15
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (17 Å)
主引用文献A Ph Domain in Acap1 Possesses Key Features of the Bar Domain in Promoting Membrane Curvature.
Dev.Cell, 31, 2014
4CKG
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BU of 4ckg by Molmil
Helical reconstruction of ACAP1(BAR-PH domain) decorated membrane tubules by cryo-electron microscopy
分子名称: ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1
著者Pang, X.Y, Fan, J, Zhang, Y, Zhang, K, Gao, B.Q, Ma, J, Li, J, Deng, Y.C, Zhou, Q.J, Hsu, V, Sun, F.
登録日2014-01-06
公開日2014-10-15
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (15 Å)
主引用文献A Ph Domain in Acap1 Possesses Key Features of the Bar Domain in Promoting Membrane Curvature.
Dev.Cell, 31, 2014
5JJD
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BU of 5jjd by Molmil
crystal structure of the ceramide transfer protein PH and START domain complex
分子名称: Collagen type IV alpha-3-binding protein, DI(HYDROXYETHYL)ETHER, TRIETHYLENE GLYCOL
著者Prashek, J, Bouyain, S, Yao, X.
登録日2016-04-23
公開日2017-07-05
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.403 Å)
主引用文献Interaction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain.
J. Biol. Chem., 292, 2017
1NTY
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BU of 1nty by Molmil
Crystal structure of the first DH/PH domain of Trio to 1.7 A
分子名称: Triple functional domain protein
著者Skowronek, K.R, Zheng, Y, Nassar, N.
登録日2003-01-30
公開日2004-06-29
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids.
J.Biol.Chem., 279, 2004
1QQG
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CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1
分子名称: INSULIN RECEPTOR SUBSTRATE 1
著者Dhe-Paganon, S, Shoelson, S.E.
登録日1999-06-04
公開日1999-08-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1.
Proc.Natl.Acad.Sci.USA, 96, 1999
6TSE
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BU of 6tse by Molmil
Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
分子名称: 1-methylindole-2,3-dione, MAGNESIUM ION, Tyrosine-protein kinase BTK, ...
著者Brear, P, Wagstaff, J, Hyvonen, M.
登録日2019-12-20
公開日2020-11-25
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
To Be Published
6U3E
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BU of 6u3e by Molmil
Best fitting antiparallel model for Volume 1 of truncated dimeric Cytohesin-3 (Grp1; amino acids 14-399)
分子名称: Cytohesin-3, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE
著者Das, S, Lambright, D.G.
登録日2019-08-21
公開日2019-09-25
最終更新日2023-11-29
実験手法ELECTRON MICROSCOPY (53 Å)
主引用文献Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes.
Structure, 27, 2019
3LJU
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BU of 3lju by Molmil
Crystal structure of full length centaurin alpha-1 bound with the head group of PIP3
分子名称: (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, Arf-GAP with dual PH domain-containing protein 1, ZINC ION
著者Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2010-01-26
公開日2010-11-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.702 Å)
主引用文献Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
Proc.Natl.Acad.Sci.USA, 107, 2010
6TVN
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BU of 6tvn by Molmil
Crystal Structure of 5-bromoindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase
分子名称: 5-bromanyl-1,3-dihydroindol-2-one, MAGNESIUM ION, Tyrosine-protein kinase BTK, ...
著者Brear, P, Wagstaff, J, Hyvonen, M.
登録日2020-01-10
公開日2020-11-25
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
To Be Published
4GMV
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BU of 4gmv by Molmil
Crystal Structure of the coiled-coil, RA and PH domains of Lamellipodin
分子名称: Ras-associated and pleckstrin homology domains-containing protein 1
著者Chang, Y.C.E, Wu, J.
登録日2012-08-16
公開日2012-11-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.403 Å)
主引用文献Crystal structure of Lamellipodin implicates diverse functions in actin polymerization and Ras signaling.
Protein Cell, 4, 2013
4H8S
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BU of 4h8s by Molmil
Crystal structure of human APPL2BARPH domain
分子名称: DCC-interacting protein 13-beta
著者Martin, J.L, King, G.J.
登録日2012-09-23
公開日2012-10-17
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Membrane Curvature Protein Exhibits Interdomain Flexibility and Binds a Small GTPase.
J.Biol.Chem., 287, 2012
6U3G
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BU of 6u3g by Molmil
Best fitting antiparallel model for Volume 2 of truncated dimeric Cytohesin-3 (Grp1; amino acids 14-399)
分子名称: Cytohesin-3, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE
著者Das, S, Lambright, D.G.
登録日2019-08-21
公開日2019-09-25
最終更新日2023-11-29
実験手法ELECTRON MICROSCOPY (53 Å)
主引用文献Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes.
Structure, 27, 2019
3MDB
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BU of 3mdb by Molmil
Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4
分子名称: (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, Arf-GAP with dual PH domain-containing protein 1, Kinesin-like protein KIF13B, ...
著者Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2010-03-30
公開日2010-08-04
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.952 Å)
主引用文献Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4
to be published
3MPX
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BU of 3mpx by Molmil
Crystal structure of the DH and PH-1 domains of human FGD5
分子名称: FYVE, RhoGEF and PH domain-containing protein 5, UNKNOWN ATOM OR ION
著者Shen, Y, Nedyalkova, L, Tong, Y, Tempel, W, Crombet, L, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2010-04-27
公開日2010-06-23
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of the DH and PH-1 domains of human FGD5
TO BE PUBLISHED
4GN1
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BU of 4gn1 by Molmil
Crystal Structure of the RA and PH domains of Lamellipodin
分子名称: MALONATE ION, Ras-associated and pleckstrin homology domains-containing protein 1
著者Chang, Y.C.E, Wu, J.
登録日2012-08-16
公開日2012-11-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of Lamellipodin implicates diverse functions in actin polymerization and Ras signaling.
Protein Cell, 4, 2013
4GZU
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BU of 4gzu by Molmil
Crystal structure of the DH-PH-PH domain of FARP2
分子名称: FERM, RhoGEF and pleckstrin domain-containing protein 2
著者He, X, Zhang, X.
登録日2012-09-06
公開日2013-03-13
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
Structure, 21, 2013
6TUH
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BU of 6tuh by Molmil
The PH domain of Bruton's tyrosine kinase mutant R28C
分子名称: 4,5,6,7-tetrahydro-1-benzofuran-3-carboxylic acid, MAGNESIUM ION, Tyrosine-protein kinase BTK, ...
著者Brear, P, Wagstaff, J, Hyvonen, M.
登録日2020-01-07
公開日2020-11-25
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
To Be Published
4H6Y
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BU of 4h6y by Molmil
Crystal structure of the DH-PH-PH domain of FARP1
分子名称: FERM, RhoGEF and pleckstrin domain-containing protein 1
著者He, X, Zhang, X.
登録日2012-09-19
公開日2013-03-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (4.09 Å)
主引用文献Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
Structure, 21, 2013
2LKO
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BU of 2lko by Molmil
Structural Basis of Phosphoinositide Binding to Kindlin-2 Pleckstrin Homology Domain in Regulating Integrin Activation
分子名称: Fermitin family homolog 2, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE
著者Liu, J, Fukuda, K, Xu, Z.
登録日2011-10-17
公開日2011-10-26
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation.
J.Biol.Chem., 286, 2011
2R0D
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BU of 2r0d by Molmil
Crystal Structure of Autoinhibited Form of Grp1 Arf GTPase Exchange Factor
分子名称: Cytohesin-3, DI(HYDROXYETHYL)ETHER, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, ...
著者DiNitto, J.P, Delprato, A, Gabe Lee, M.T, Cronin, T.C, Huang, S, Guilherme, A, Czech, M.P, Lambright, D.G.
登録日2007-08-18
公開日2007-12-04
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange Factors.
Mol.Cell, 28, 2007
3SNH
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BU of 3snh by Molmil
Crystal structure of nucleotide-free human dynamin1
分子名称: Dynamin-1
著者Faelber, K, Daumke, O.
登録日2011-06-29
公開日2011-09-21
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Crystal structure of nucleotide-free dynamin.
Nature, 477, 2011

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件を2024-07-10に公開中

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