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PDB: 409 件

3EOV
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Crystal structure of cyclophilin from Leishmania donovani ligated with cyclosporin A
分子名称: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
著者Venugopal, V, Dasgupta, D, Datta, A.K, Banerjee, R.
登録日2008-09-29
公開日2008-11-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of Cyclophilin from Leishmania Donovani Bound to Cyclosporin at 2.6 A Resolution: Correlation between Structure and Thermodynamic Data.
Acta Crystallogr.,Sect.D, 65, 2009
1E8K
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Cyclophilin 3 Complexed With Dipeptide Ala-Pro
分子名称: ALANINE, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE 3, PROLINE
著者Wu, S.Y, Dornan, J, Kontopidis, G, Taylor, P, Walkinshaw, M.D.
登録日2000-09-25
公開日2001-09-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The First Direct Determination of a Ligand Binding Constant in Protein Crystals
Angew.Chem.Int.Ed.Engl., 40, 2001
8B58
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Crystal Structure of Cyclophilin TgCyp23 from Toxoplasma gondii in complex with Cyclosporin A
分子名称: Cyclosporin A, Peptidyl-prolyl cis-trans isomerase
著者Jimenez-Faraco, E, Hermoso, J.A.
登録日2022-09-22
公開日2023-02-01
最終更新日2023-02-22
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Structural Basis for Cyclosporin Isoform-Specific Inhibition of Cyclophilins from Toxoplasma gondii .
Acs Infect Dis., 9, 2023
7ZFM
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Engineered Protein Targeting the Zika Viral Envelope Fusion Loop
分子名称: 1,2-ETHANEDIOL, ACETIC ACID, HEXAETHYLENE GLYCOL, ...
著者Athayde, D, Archer, M, Viana, I.F.T, Adan, W.C.S, Xavier, L.S.S, Lins, R.D.
登録日2022-04-01
公開日2022-08-17
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.711 Å)
主引用文献In Vitro Neutralisation of Zika Virus by an Engineered Protein Targeting the Viral Envelope Fusion Loop
SSRN, 2022
1W8L
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Enzymatic and structural characterization of non peptide ligand cyclophilin complexes
分子名称: (3R)-1-ACETYL-3-METHYLPIPERIDINE, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
著者Kontopidis, G, Taylor, P, Walkinshaw, M.
登録日2004-09-23
公開日2004-09-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Enzymatic and Structural Characterization of Non-Peptide Ligand-Cyclophilin Complexes
Acta Crystallogr.,Sect.D, 60, 2004
1MIK
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THE ROLE OF WATER MOLECULES IN THE STRUCTURE-BASED DESIGN OF (5-HYDROXYNORVALINE)-2-CYCLOSPORIN: SYNTHESIS, BIOLOGICAL ACTIVITY, AND CRYSTALLOGRAPHIC ANALYSIS WITH CYCLOPHILIN A
分子名称: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
著者Mikol, V.
登録日1995-09-20
公開日1996-03-08
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献The Role of Water Molecules in the Structure-Based Design of (5-Hydroxynorvaline)-2-Cyclosporin: Synthesis, Biological Activity, and Crystallographic Analysis with Cyclophilin A.
J.Med.Chem., 38, 1995
8CU5
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Crystal Structure of Putative Cyclophilin B from Brugia malayi
分子名称: 1,2-ETHANEDIOL, Peptidyl-prolyl cis-trans isomerase, SULFATE ION
著者Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2022-05-16
公開日2022-05-25
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal Structure of Putative Cyclophilin B from Brugia malayi
to be published
1W74
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X-ray structure of peptidyl-prolyl cis-trans isomerase A, PpiA, Rv0009, from Mycobacterium tuberculosis.
分子名称: PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
著者Henriksson, L.M, Johansson, P, Unge, T, Mowbray, S.L.
登録日2004-08-27
公開日2004-10-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献X-Ray Structure of Peptidyl-Prolyl Cis-Trans Isomerase a from Mycobacterium Tuberculosis
Eur.J.Biochem., 271, 2004
7ZDN
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Human Cyclophilin D in complex with fragment
分子名称: (1~{R},9~{R},10~{S})-12-oxa-8-azatricyclo[7.3.1.0^{2,7}]trideca-2(7),3,5-trien-10-ol, Peptidyl-prolyl cis-trans isomerase F, mitochondrial
著者Silva, D.O, Graedler, U, Bandeiras, T.M.
登録日2022-03-29
公開日2023-04-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Human Cyclophilin D in complex with fragment
To Be Published
1FGL
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Cyclophilin A complexed with a fragment of HIV-1 GAG protein
分子名称: CYCLOPHILIN A, HIV-1 GAG PROTEIN
著者Zhao, Y, Chen, Y, Schutkowski, M, Fischer, G, Ke, H.
登録日1996-11-18
公開日1997-04-01
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Cyclophilin A complexed with a fragment of HIV-1 gag protein: insights into HIV-1 infectious activity.
Structure, 5, 1997
7L6Y
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Crystal Structure of the Peptidyl-Prolyl Cis-Trans Isomerase (PpiB) from Streptococcus pyogenes.
分子名称: Peptidyl-prolyl cis-trans isomerase
著者Minasov, G, Shuvalova, L, Kiryukhina, O, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2020-12-24
公開日2021-12-01
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Crystal Structure of the Peptidyl-Prolyl Cis-Trans Isomerase (PpiB) from Streptococcus pyogenes.
To Be Published
7L6Z
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Crystal Structure of Peptidyl-Prolyl Cis-Trans Isomerasefrom (PpiB) Streptococcus pneumoniae R6
分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ...
著者Minasov, G, Shuvalova, L, Kiryukhina, O, Dubrovska, I, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2020-12-24
公開日2021-12-01
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Crystal Structure of Peptidyl-Prolyl Cis-Trans Isomerasefrom (PpiB) Streptococcus pneumoniae R6
To Be Published
8HZ8
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Structure of PPIA in complex with the peptide of NRF2
分子名称: NRF2 peptide, Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
著者Wanyan, W, Hui, M, Jin, H, Lu, W.
登録日2023-01-08
公開日2024-03-13
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Structure of PPIA in complex with the peptide of NRF2
To Be Published
1H0P
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Cyclophilin_5 from C. elegans
分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE 5
著者Picken, N.C, Eschenlauer, S, Taylor, P, Page, A.P, Walkinshaw, M.D.
登録日2002-06-26
公開日2002-09-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural and Biological Characterisation of the Gut-Associated Cyclophilin B Isoforms from Caenorhabditis Elegans
J.Mol.Biol., 322, 2002
8EJX
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Crystal structure of human cyclophilin D (CypD) with in complex with the covalently bound Ebselen inhibitor
分子名称: N-phenyl-2-selanylbenzamide, Peptidyl-prolyl cis-trans isomerase F, mitochondrial
著者Lovell, S, Battaile, K.P, Yan, S.
登録日2022-09-19
公開日2023-10-18
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献New cyclophilin D inhibitor rescues mitochondrial and cognitive function in Alzheimer's disease.
Brain, 147, 2024
6BTA
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CypA Mutant - S99T C115S
分子名称: Peptidyl-prolyl cis-trans isomerase A
著者Fraser, J.S, Kenner, L.R, Liu, L.
登録日2017-12-06
公開日2018-04-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Rescue of conformational dynamics in enzyme catalysis by directed evolution.
Nat Commun, 9, 2018
2R99
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Crystal structure of cyclophilin ABH-like domain of human peptidylprolyl isomerase E isoform 1
分子名称: Peptidyl-prolyl cis-trans isomerase E
著者Walker, J.R, Davis, T, Newman, E.M, Mackenzie, F, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2007-09-12
公開日2007-09-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
5A0E
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Crystal structure of cyclophilin D in complex with CsA analogue, JW47.
分子名称: JW47, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE F, MITOCHONDRIAL
著者Warne, J, Pryce, G, Hill, J, Shi, X, Lenneras, F, Puentes, F, Kip, M, Hilditch, L, Walker, P, Simone, M, Chan, A.W.E, Towers, G, Coker, A.R, Duchen, M, Szabadkai, G, Baker, D, Selwood, D.L.
登録日2015-04-19
公開日2015-12-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects Against Neuro-Degeneration in Experimental Multiple Sclerosis.
J.Biol.Chem., 291, 2016
4ZSD
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Human Cyclophilin D Complexed with an Inhibitor at room temperature
分子名称: 1-(4-aminobenzyl)-3-[(2S)-4-(methylsulfanyl)-1-{(2R)-2-[2-(methylsulfanyl)phenyl]pyrrolidin-1-yl}-1-oxobutan-2-yl]urea, Peptidyl-prolyl cis-trans isomerase F, mitochondrial
著者Gelin, M, Delfosse, V, Allemand, F, Hoh, F, Sallaz-Damaz, Y, Pirocchi, M, Bourguet, W, Ferrer, J.-L, Labesse, G, Guichou, J.-F.
登録日2015-05-13
公開日2015-08-12
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.
Acta Crystallogr.,Sect.D, 71, 2015
4ZSC
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Human Cyclophilin D Complexed with an Inhibitor at room temperature
分子名称: Peptidyl-prolyl cis-trans isomerase F, mitochondrial, ethyl N-[(4-aminobenzyl)carbamoyl]glycinate
著者Gelin, M, Delfosse, V, Allemand, F, Hoh, F, Sallaz-Damaz, Y, Pirocchi, M, Bourguet, W, Ferrer, J.-L, Labesse, G, Guichou, J.-F.
登録日2015-05-13
公開日2015-08-12
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.
Acta Crystallogr.,Sect.D, 71, 2015
2RMC
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Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A
分子名称: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE C
著者Ke, H, Zhao, Y, Luo, F, Weissman, I, Friedman, J.
登録日1994-01-07
公開日1995-02-14
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Crystal Structure of Murine Cyclophilin C Complexed with Immunosuppressive Drug Cyclosporin A
Proc.Natl.Acad.Sci.USA, 90, 1993
2RMA
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Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A
分子名称: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
著者Ke, H, Mayrose, D.
登録日1994-01-07
公開日1995-02-07
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structures of Cyclophilin a Complexed with Cyclosporin a and N-Methyl-4-[(E)-2-Butenyl]-4,4-Dimethylthreonine Cyclosporin A.
Structure, 2, 1994
7N3J
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E. coli peptidyl-prolyl cis-trans isomerase, mutant Phe27CF3-Tyr/Phe98CF3-Tyr
分子名称: Peptidyl-prolyl cis-trans isomerase B
著者Frkic, R.L, Otting, G, Jackson, C.J.
登録日2021-06-01
公開日2021-09-29
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Through-Space Scalar 19 F- 19 F Couplings between Fluorinated Noncanonical Amino Acids for the Detection of Specific Contacts in Proteins.
J.Am.Chem.Soc., 143, 2021
7OGI
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Human Cyclophilin D in complex with N-(5-ethyl-4-oxo-1,2,3,4,5,6-hexahydro-1,5-benzodiazocin-8-yl)-7methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide
分子名称: DIMETHYL SULFOXIDE, N-(5-ethyl-4-oxidanylidene-1,2,3,6-tetrahydro-1,5-benzodiazocin-8-yl)-7-methyl-2-oxidanylidene-1H-pyrazolo[1,5-a]pyrimidine-6-carboxamide, Peptidyl-prolyl cis-trans isomerase F, ...
著者Silva, D.O, Graedler, U, Bandeiras, T.M.
登録日2021-05-06
公開日2022-06-01
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.01 Å)
主引用文献Human Cyclophilin D in complex with N-(5-ethyl-4-oxo-1,2,3,4,5,6-hexahydro-1,5-benzodiazocin-8-yl)-7methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide
To Be Published
6U5C
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RT XFEL structure of CypA solved using MESH injection system
分子名称: Peptidyl-prolyl cis-trans isomerase A
著者Wolff, A.M, Thompson, M.C.
登録日2019-08-27
公開日2020-01-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals
Iucrj, 7, 2020

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件を2024-07-17に公開中

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