8EJX
Crystal structure of human cyclophilin D (CypD) with in complex with the covalently bound Ebselen inhibitor
Summary for 8EJX
Entry DOI | 10.2210/pdb8ejx/pdb |
Descriptor | Peptidyl-prolyl cis-trans isomerase F, mitochondrial, N-phenyl-2-selanylbenzamide (3 entities in total) |
Functional Keywords | isomerase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 18031.40 |
Authors | Lovell, S.,Battaile, K.P.,Yan, S. (deposition date: 2022-09-19, release date: 2023-10-18, Last modification date: 2024-05-15) |
Primary citation | Samanta, S.,Akhter, F.,Roy, A.,Chen, D.,Turner, B.,Wang, Y.,Clemente, N.,Wang, C.,Swerdlow, R.H.,Battaile, K.P.,Lovell, S.,Yan, S.F.,Yan, S.S. New cyclophilin D inhibitor rescues mitochondrial and cognitive function in Alzheimer's disease. Brain, 147:1710-1725, 2024 Cited by PubMed: 38146639DOI: 10.1093/brain/awad432 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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