8EJX

Crystal structure of human cyclophilin D (CypD) with in complex with the covalently bound Ebselen inhibitor

Summary for 8EJX

Entry DOI	10.2210/pdb8ejx/pdb
Descriptor	Peptidyl-prolyl cis-trans isomerase F, mitochondrial, N-phenyl-2-selanylbenzamide (3 entities in total)
Functional Keywords	isomerase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	18031.40
Authors	Lovell, S.,Battaile, K.P.,Yan, S. (deposition date: 2022-09-19, release date: 2023-10-18, Last modification date: 2024-01-10)
Primary citation	Samanta, S.,Akhter, F.,Roy, A.,Chen, D.,Turner, B.,Wang, Y.,Clemente, N.,Wang, C.,Swerdlow, R.H.,Battaile, K.P.,Lovell, S.,Yan, S.F.,Yan, S.S. New cyclophilin D inhibitor rescues mitochondrial and cognitive function in Alzheimer's disease. Brain, 2023 Cited by PubMed: 38146639 DOI: 10.1093/brain/awad432 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation