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PDB: 730 件
1C86
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V,D48N) COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
分子名称: 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)
著者Iversen, L.F, Andersen, H.S, Mortensen, S.B, Moller, N.P.
登録日2000-04-16
公開日2000-05-03
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
J.Biol.Chem., 275, 2000
1BZH
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Cyclic peptide inhibitor of human PTP1B
分子名称: PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITOR), PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B)
著者Groves, M.R, Yao, Z.J, Burke Jr, T.R, Barford, D.
登録日1998-10-28
公開日1999-02-16
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1BZJ
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Human ptp1b complexed with tpicooh
分子名称: 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE)
著者Groves, M.R, Yao, Z.-J, Barford Jr, D.T.B.
登録日1998-10-29
公開日1999-02-16
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1BZC
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HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI
分子名称: 4-CARBAMOYL-4-{[6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBONYL]-AMINO}-BUTYRIC ACID, PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE)
著者Groves, M.R, Yao, Z.J, Jr Burke, T.R, Barford, D.
登録日1998-10-27
公開日1999-02-16
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1A5Y
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PROTEIN TYROSINE PHOSPHATASE 1B CYSTEINYL-PHOSPHATE INTERMEDIATE
分子名称: PROTEIN TYROSINE PHOSPHATASE 1B
著者Pannifer, A.D.P, Flint, A.J, Tonks, N.K, Barford, D.
登録日1998-02-19
公開日1998-06-17
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography.
J.Biol.Chem., 273, 1998
1AAX
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO BIS(PARA-PHOSPHOPHENYL)METHANE (BPPM) MOLECULES
分子名称: 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN, MAGNESIUM ION, PROTEIN TYROSINE PHOSPHATASE 1B
著者Puius, Y.A, Zhao, Y, Sullivan, M, Lawrence, D, Almo, S.C, Zhang, Z.-Y.
登録日1997-01-16
公開日1998-03-04
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design.
Proc.Natl.Acad.Sci.USA, 94, 1997
1EEN
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-D-A-D-BPA-PTYR-L-I-P-Q-Q-G
分子名称: ACETIC ACID, ALA-ASP-PBF-PTR-LEU-ILE-PRO, MAGNESIUM ION, ...
著者Puius, Y.A, Zhao, Y, Almo, S.C, Zhang, Z.Y.
登録日2000-02-01
公開日2001-02-01
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.
Biochemistry, 39, 2000
1ECV
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 5-IODO-2-(OXALYL-AMINO)-BENZOIC ACID
分子名称: 5-IODO-2-(OXALYL-AMINO)-BENZOIC ACID, ACETATE ION, PROTEIN-TYROSINE PHOSPHATASE 1B
著者Andersen, H.S, Iversen, L.F, Branner, S, Rasmussen, H.B, Moller, N.P.H.
登録日2000-01-26
公開日2000-03-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1EEO
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-E-L-E-F-PTYR-M-D-Y-E-NH2
分子名称: ACETYL-E-L-E-F-PTYR-M-D-Y-E-NH2 PEPTIDE, MAGNESIUM ION, PROTEIN TYROSINE PHOSPHATASE 1B
著者Sarmiento, M, Puius, Y.A, Vetter, S.W, Lawrence, D.S, Almo, S.C, Zhang, Z.Y.
登録日2000-02-01
公開日2001-02-01
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.
Biochemistry, 39, 2000
4GE6
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Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 7
分子名称: N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithyl-3-{[(4-hydroxy-3-methoxyphenyl)acetyl]amino}-D-alaninamide, Tyrosine-protein phosphatase non-receptor type 9
著者Zhang, Z.-Y, Liu, S, Zhang, S.
登録日2012-08-01
公開日2012-10-31
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes.
J.Am.Chem.Soc., 134, 2012
4GE2
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Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 3
分子名称: N-acetyl-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide, Tyrosine-protein phosphatase non-receptor type 9
著者Zhang, Z.-Y, Liu, S, Zhang, S.
登録日2012-08-01
公開日2012-10-31
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes.
J.Am.Chem.Soc., 134, 2012
4GFU
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PTPN18 in complex with HER2-pY1248 phosphor-peptides
分子名称: HER2-pY1248 phosphor-peptide, Tyrosine-protein phosphatase non-receptor type 18
著者Wang, H.M, Yang, F, Du, Y.J, Yang, D.X, Zhang, Y, Yu, X, Sun, J.P.
登録日2012-08-04
公開日2013-08-07
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献PTPN18-HER2 peptides
To be Published
4GFV
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PTPN18 in complex with HER2-pY1196 phosphor-peptides
分子名称: HER2-pY1196 phosphor-peptide, Tyrosine-protein phosphatase non-receptor type 18
著者Wang, H.M, Yang, F, Du, Y.J, Yang, D.X, Zhang, Y, Yu, X, Sun, J.P.
登録日2012-08-04
公開日2013-10-23
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.095 Å)
主引用文献PTPN18-HER2 peptides
To be Published
4GE5
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Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 5
分子名称: N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide, Tyrosine-protein phosphatase non-receptor type 9
著者Zhang, Z.-Y, Liu, S, Zhang, S.
登録日2012-08-01
公開日2012-10-31
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes.
J.Am.Chem.Soc., 134, 2012
7MN7
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PTP1B F225Y in complex with TCS401
分子名称: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-04-30
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MNA
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PTP1B 1-284 F225Y-R199N in complex with TCS401
分子名称: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-04-30
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MKZ
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PTP1B F225Y mutant, open state
分子名称: CHLORIDE ION, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-04-27
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MNC
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PTP1B L204A
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 1
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-04-30
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MNF
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PTP1B P206G in complex with TCS401
分子名称: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-04-30
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MND
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PTP1B L204A in complex with TCS401
分子名称: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-04-30
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MNB
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PTP1B F225Y-R199N-L195R in complex with TCS401
分子名称: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, CHLORIDE ION, GLYCEROL, ...
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-04-30
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MNE
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PTP1B P206G mutation, open state
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ...
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-04-30
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MOV
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PTP1B 1-301 F225Y-R199N mutations
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ...
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-05-03
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
4GRZ
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Crystal structure of SHP1 catalytic domain with PO4
分子名称: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 6
著者Alicea-Velazquez, N.L, Jakoncic, J, Boggon, T.J.
登録日2012-08-27
公開日2012-12-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.3732 Å)
主引用文献Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition.
J.Struct.Biol., 181, 2013
4GS0
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Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide
分子名称: Tyrosine-protein kinase JAK1, Tyrosine-protein phosphatase non-receptor type 6
著者Alicea-Velazquez, N.L, Jakoncic, J, Boggon, T.J.
登録日2012-08-27
公開日2012-12-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.7961 Å)
主引用文献Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition.
J.Struct.Biol., 181, 2013

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