1EEO

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-E-L-E-F-PTYR-M-D-Y-E-NH2

Summary for 1EEO

• Entry DOI: 10.2210/pdb1eeo/pdb
• Related: 1EEN
• Descriptor: PROTEIN TYROSINE PHOSPHATASE 1B, ACETYL-E-L-E-F-PTYR-M-D-Y-E-NH2 PEPTIDE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: hydrolase, phosphorylation, inhibition, hydrolase-hydrolase substrate complex, hydrolase/hydrolase substrate
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
• Total number of polymer chains: 2
• Total formula weight: 38716.22

Authors

Sarmiento, M.,Puius, Y.A.,Vetter, S.W.,Lawrence, D.S.,Almo, S.C.,Zhang, Z.Y. (deposition date: 2000-02-01, release date: 2001-02-01, Last modification date: 2023-11-15)

• Primary citation: Sarmiento, M.,Puius, Y.A.,Vetter, S.W.,Keng, Y.F.,Wu, L.,Zhao, Y.,Lawrence, D.S.,Almo, S.C.,Zhang, Z.Y.; Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.; Biochemistry, 39:8171-8179, 2000; PubMed: 10889023; DOI: 10.1021/bi000319w

Experimental method

X-RAY DIFFRACTION (1.8 Å)