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PDB: 256 件
1C8O
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2.9 A STRUCTURE OF CLEAVED VIRAL SERPIN CRMA
分子名称: ICE INHIBITOR
著者Simonovic, M, Gettins, P.G.W, Volz, K.
登録日2000-06-01
公開日2000-09-06
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structure of viral serpin crmA provides insights into its mechanism of cysteine proteinase inhibition.
Protein Sci., 9, 2000
1D5S
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CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER
分子名称: P1-ARG ANTITRYPSIN
著者Dunstone, M.A, Dai, W, Whisstock, J.C, Rossjohn, J, Pike, R.N, Feil, S.C, Le Bonneic, B.F, Parker, M.W, Bottomley, S.P.
登録日1999-10-11
公開日2000-04-02
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Cleaved antitrypsin polymers at atomic resolution.
Protein Sci., 9, 2000
1C5G
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PLASMINOGEN ACTIVATOR INHIBITOR-1
分子名称: PLASMINOGEN ACTIVATOR INHIBITOR-1
著者Goldsmith, E.J.
登録日1999-12-07
公開日1999-12-17
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition.
Nat.Struct.Biol., 2, 1995
1BY7
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HUMAN PLASMINOGEN ACTIVATOR INHIBITOR-2. LOOP (66-98) DELETION MUTANT
分子名称: PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-2)
著者Harrop, S.J, King, G.C, Mabbutt, B.C, Curmi, P.M.G.
登録日1998-10-27
公開日1999-10-24
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of plasminogen activator inhibitor 2 at 2.0 A resolution: implications for serpin function.
Structure Fold.Des., 7, 1999
1ANT
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BIOLOGICAL IMPLICATIONS OF A 3 ANGSTROMS STRUCTURE OF DIMERIC ANTITHROMBIN
分子名称: ANTITHROMBIN
著者Carrell, R.W, Stein, P.E, Fermi, G, Wardell, M.R.
登録日1994-02-28
公開日1995-01-26
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Biological implications of a 3 A structure of dimeric antithrombin.
Structure, 2, 1994
1DB2
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CRYSTAL STRUCTURE OF NATIVE PLASMINOGEN ACTIVATOR INHIBITOR-1
分子名称: PLASMINOGEN ACTIVATOR INHIBITOR-1
著者Nar, H, Bauer, M, Stassen, J.M, Lang, D, Gils, A, Declerck, P.
登録日1999-11-02
公開日1999-11-10
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation.
J.Mol.Biol., 297, 2000
1AZX
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ANTITHROMBIN/PENTASACCHARIDE COMPLEX
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, ANTITHROMBIN
著者Jin, L, Abrahams, J.P, Skinner, R, Petitou, M, Pike, R.N, Carrell, R.W.
登録日1997-11-23
公開日1999-01-13
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The anticoagulant activation of antithrombin by heparin.
Proc.Natl.Acad.Sci.USA, 94, 1997
1AS4
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CLEAVED ANTICHYMOTRYPSIN A349R
分子名称: ACETATE ION, ANTICHYMOTRYPSIN
著者Lukacs, C.M, Christianson, D.W.
登録日1997-08-12
公開日1998-02-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction.
Biochemistry, 37, 1998
1DVN
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LATENT FORM OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1)
分子名称: PLASMINOGEN ACTIVATOR INHIBITOR-1
著者Stout, T.J, Graham, H, Buckley, D.I, Matthews, D.J.
登録日2000-01-21
公開日2000-09-13
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structures of active and latent PAI-1: a possible stabilizing role for chloride ions.
Biochemistry, 39, 2000
1E03
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PLASMA ALPHA ANTITHROMBIN-III AND PENTASACCHARIDE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, ...
著者McCoy, A.J, Jin, L, Abrahams, J.-P, Skinner, R, Carrell, R.W.
登録日2000-03-09
公開日2000-06-02
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of Beta-Antithrombin and the Effect of Glycosylation on Antithrombin'S Heparin Affinity and Activity.
J.Mol.Biol., 326, 2003
1DZH
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P14-FLUORESCEIN-N135Q-S380C-ANTITHROMBIN-III
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ...
著者Mccoy, A.J, Huntington, J.A, Carrell, R.W.
登録日2000-02-28
公開日2000-05-26
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献The Conformational Activation of Antithrombin. A 2. 85-A Structure of a Fluorescein Derivative Reveals an Electrostatic Link between the Hinge and Heparin Binding Regions.
J.Biol.Chem., 275, 2000
1E05
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PLASMA ALPHA ANTITHROMBIN-III
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ...
著者McCoy, A.J, Skinner, R, Abrahams, J.-P, Pei, X.Y, Carrell, R.W.
登録日2000-03-09
公開日2000-06-02
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Structure of Beta-Antithrombin and the Effect of Glycosylation on Antithrombin'S Heparin Affinity and Activity.
J.Mol.Biol., 326, 2003
1DZG
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N135Q-S380C-ANTITHROMBIN-III
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ...
著者McCoy, A.J, Huntington, J.A, Carrell, R.W.
登録日2000-02-28
公開日2000-05-26
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The Conformational Activation of Antithrombin. A 2. 85-A Structure of a Fluorescein Derivative Reveals an Electrostatic Link between the Hinge and Heparin Binding Regions.
J.Biol.Chem., 275, 2000
6HGM
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Crystal structure of Alpha1-antichymotrypsin variant NewBG-III-allo: an allosterically controlled new binding globulin with an unprecedentedly high ligand release efficacy
分子名称: 1,2-ETHANEDIOL, Alpha-1-antichymotrypsin, CALCIUM ION, ...
著者Schmidt, K, Muller, Y.A.
登録日2018-08-23
公開日2019-05-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.369 Å)
主引用文献NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly high ligand release efficacy.
J.Struct.Biol., 207, 2019
6HX4
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Fab fragment of a native monomer-selective antibody in complex with alpha-1-antitrypsin
分子名称: Alpha-1-antitrypsin, Fab 1D9 heavy chain, Fab 1D9 light chain
著者Elliston, E.L.K, Miranda, E, Perez, J, Jagger, A.M, Lomas, D.A, Irving, J.A.
登録日2018-10-15
公開日2019-10-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Characterisation of a monoclonal antibody conformationally-selective for native alpha-1-antitrypsin
To Be Published
6HGF
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Crystal structure of Alpha1-antichymotrypsin variant NewBG-II: a new binding globulin in complex with cortisol
分子名称: (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, 1,2-ETHANEDIOL, Alpha-1-antichymotrypsin
著者Schmidt, K, Muller, Y.A.
登録日2018-08-23
公開日2019-05-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.651 Å)
主引用文献NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly high ligand release efficacy.
J.Struct.Biol., 207, 2019
6HGH
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Crystal structure of Alpha1-antichymotrypsin variant NewBG-III: a new binding globulin without any bound ligand
分子名称: Alpha-1-antichymotrypsin, MALONIC ACID, alpha1-Antichymotrypsin
著者Schmidt, K, Muller, Y.A.
登録日2018-08-23
公開日2019-05-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly high ligand release efficacy.
J.Struct.Biol., 207, 2019
6HGI
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Crystal structure of Alpha1-antichymotrypsin variant NewBG-III: a new binding globulin in complex with corticosterone
分子名称: Alpha-1-antichymotrypsin, CORTICOSTERONE
著者Schmidt, K, Muller, Y.A.
登録日2018-08-23
公開日2019-05-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.517 Å)
主引用文献NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly high ligand release efficacy.
J.Struct.Biol., 207, 2019
6I7U
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Alpha-1-antitrypsin (Ala250Met) in the native conformation
分子名称: Alpha-1-antitrypsin
著者Aldobiyan, I, Lomas, D.A, Irving, J.A.
登録日2018-11-19
公開日2019-11-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structural determinants of instability in alpha-1-antitrypsin
To Be Published
6I3I
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Crystal structure of reactive center loop (RCL) cleaved angiotensinogen
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensinogen
著者Yan, Y, Read, R.J.
登録日2018-11-06
公開日2018-12-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.97 Å)
主引用文献Structural basis for the specificity of renin-mediated angiotensinogen cleavage.
J. Biol. Chem., 294, 2019
6I8S
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Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1
分子名称: HEAVY CHAIN OF FAB FRAGMENT FROM AN PAI-1 ANTIBODY, LIGHT CHAIN OF FAB FRAGMENT FROM AN PAI-1 ANTIBODY, Plasminogen activator inhibitor 1
著者Vousden, K.A, Lundqvist, T, Popovic, B.
登録日2018-11-21
公開日2019-02-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1.
Sci Rep, 9, 2019
6I4V
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Alpha-1-antitrypsin Queen's (K154N) variant
分子名称: 3-trimethylsilylpropane-1-sulfonic acid, Alpha-1-antitrypsin, GLYCINE
著者Aldobiyan, I, Lomas, D.A, Irving, J.A.
登録日2018-11-12
公開日2019-11-20
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Structural determinants of instability in alpha-1-antitrypsin
To Be Published
6IAY
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Alpha-1-antitrypsin Queen's (Lys154Asn) variant
分子名称: Alpha-1-antitrypsin, GLYCINE
著者Aldobiyan, I, Lomas, D.A, Irving, J.A.
登録日2018-11-28
公開日2019-12-18
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural determinants of instability in alpha-1-antitrypsin
To Be Published
6I3Z
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Fab fragment of an antibody selective for wild-type alpha-1-antitrypsin in complex with its antigen
分子名称: Alpha-1-antitrypsin, Fab 2H2 heavy chain, Fab 2H2 light chain, ...
著者Laffranchi, M, Elliston, E.L.K, Miranda, E, Perez, J, Jagger, A.M, Fra, A, Lomas, D.A, Irving, J.A.
登録日2018-11-08
公開日2019-11-20
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin.
JCI Insight, 5, 2020
6GWN
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Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64)
分子名称: Plasminogen activator inhibitor 1, VHH-2g-42, VHH-2w-64
著者Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J.
登録日2018-06-25
公開日2020-01-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.
J.Thromb.Haemost., 18, 2020

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