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PDB: 1371 件
1ULW
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Crystal structure of P450nor Ser73Gly/Ser75Gly mutant
分子名称: Cytochrome P450 55A1, PROTOPORPHYRIN IX CONTAINING FE
著者Oshima, R, Fushinobu, S, Su, F, Li, Z, Takaya, N, Shoun, H.
登録日2003-09-16
公開日2004-10-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural evidence for direct hydride transfer from NADH to cytochrome P450nor
J.Mol.Biol., 342, 2004
1XQD
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Crystal structure of P450NOR complexed with 3-pyridinealdehyde adenine dinucleotide
分子名称: CYTOCHROME P450 55A1, NICOTINIC ACID ADENINE DINUCLEOTIDE, PROTOPORPHYRIN IX CONTAINING FE
著者Oshima, R, Fushinobu, S, Takaya, N, Su, F, Wakagi, T, Shoun, H.
登録日2004-10-12
公開日2004-10-26
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural evidence for direct hydride transfer from NADH to cytochrome P450nor
J.Mol.Biol., 342, 2004
1U13
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Crystal structure analysis of the C37L/C151T/C442A-triple mutant of CYP51 from Mycobacterium tuberculosis
分子名称: Cytochrome P450 51, PROTOPORPHYRIN IX CONTAINING FE
著者Podust, L.M, Yermalitskaya, L.V, Kim, Y, Waterman, M.R.
登録日2004-07-14
公開日2004-07-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Crystal structure analysis of the C37L/C151T/C442A-triple mutant of CYP51 from Mycobacterium tuberculosis
To be published
4UYM
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Crystal structure of sterol 14-alpha demethylase (CYP51B) from a pathogenic filamentous fungus Aspergillus fumigatus in complex with voriconazole
分子名称: 14-ALPHA STEROL DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, Voriconazole
著者Hargrove, T.Y, Wawrzak, Z, Lepesheva, G.I.
登録日2014-09-02
公開日2015-08-19
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structure-Functional Characterization of Cytochrome P450 Sterol Alpha-Demethylase (Cyp51B) from Aspergillus Fumigatus and Molecular Basis for the Development of Antifungal Drugs
J.Biol.Chem., 290, 2015
6WGW
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CYP101D1 D259E Hydroxycamphor bound
分子名称: 5-EXO-HYDROXYCAMPHOR, CAMPHOR, Cytochrome P450 101D1, ...
著者Amaya, J.A, Poulos, T.L, Batabyal, D.
登録日2020-04-06
公開日2020-07-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Proton Relay Network in the Bacterial P450s: CYP101A1 and CYP101D1.
Biochemistry, 59, 2020
6WPL
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Structure of Cytochrome P450tcu
分子名称: 5-EXO-HYDROXYCAMPHOR, Cytochrome P-450cam, subunit of camphor 5-monooxygenase system, ...
著者Murarka, V.C, Batabyal, D, Amaya, J.A, Sevrioukova, I.F, Poulos, T.L.
登録日2020-04-27
公開日2020-07-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.097 Å)
主引用文献Unexpected Differences between Two Closely Related Bacterial P450 Camphor Monooxygenases.
Biochemistry, 59, 2020
4WNT
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Human Cytochrome P450 2D6 Ajmalicine Complex
分子名称: Ajmalicine, Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Wang, A, Stout, C.D, Johnson, E.F.
登録日2014-10-14
公開日2015-01-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding.
J.Biol.Chem., 290, 2015
4WPZ
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Crystal structure of cytochrome P450 CYP107W1 from Streptomyces avermitilis
分子名称: Cytochrome P450, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE
著者Kang, L.W, Kim, D.H, Pham, T.V, Han, S.H.
登録日2014-10-21
公開日2015-04-22
最終更新日2015-04-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Functional characterization of CYP107W1 from Streptomyces avermitilis and biosynthesis of macrolide oligomycin A.
Arch.Biochem.Biophys., 575, 2015
4WG2
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P411BM3-CIS T438S I263F regioselective C-H amination catalyst
分子名称: Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
著者Hyster, T.K, Farwell, C.C, Buller, A.R, McIntosh, J.A, Arnold, F.H.
登録日2014-09-17
公開日2014-11-05
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献Enzyme-controlled nitrogen-atom transfer enables regiodivergent C-h amination.
J.Am.Chem.Soc., 136, 2014
6WR1
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Human steroidogenic cytochrome P450 17A1 mutant N52Y with inhibitor abiraterone
分子名称: Abiraterone, PROTOPORPHYRIN IX CONTAINING FE, Steroid 17-alpha-hydroxylase/17,20 lyase
著者Petrunak, E.M, Bart, A.G, Scott, E.E.
登録日2020-04-29
公開日2021-05-05
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site.
J.Biol.Chem., 299, 2023
6WR0
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Human steroidogenic cytochrome P450 17A1 with 3-keto-delta4-abiraterone analog
分子名称: (8alpha)-17-(pyridin-3-yl)androsta-4,16-dien-3-one, CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Petrunak, E.M, Bart, A.G, Scott, E.E.
登録日2020-04-29
公開日2021-05-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site.
J.Biol.Chem., 299, 2023
6WZP
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The crystal structure of 4-vinylbenzoate-bound T252A mutant CYP199A4
分子名称: 4-ethenylbenzoic acid, CHLORIDE ION, Cytochrome P450, ...
著者Coleman, T, Bruning, J.B, Bell, S.G.
登録日2020-05-14
公開日2021-05-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Understanding the Mechanistic Requirements for Efficient and Stereoselective Alkene Epoxidation by a Cytochrome P450 Enzyme
Acs Catalysis, 11, 2021
6WW0
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Human steroidogenic cytochrome P450 17A1 with 3-keto-5alpha-abiraterone analog
分子名称: (5alpha,8alpha)-17-(pyridin-3-yl)androst-16-en-3-one, CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Petrunak, E.M, Bart, A.G, Scott, E.E.
登録日2020-05-07
公開日2021-05-26
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site.
J.Biol.Chem., 299, 2023
4WNW
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Human Cytochrome P450 2D6 Thioridazine Complex
分子名称: 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine, Cytochrome P450 2D6, NICKEL (II) ION, ...
著者Wang, A, Stout, C.D, Johnson, E.F.
登録日2014-10-14
公開日2015-01-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.299 Å)
主引用文献Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding.
J.Biol.Chem., 290, 2015
4WQ0
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Crystal structure of cytochrome P450 CYP107W1 from Streptomyces avermitilis in complex with Oligomycin A
分子名称: Cytochrome P450, Oligomycin A, PROTOPORPHYRIN IX CONTAINING FE
著者Kang, L.W, Kim, D.H, Pham, T.V, Han, S.H.
登録日2014-10-21
公開日2015-10-28
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of cytochrome P450 CYP107W1 from Streptomyces avermitilis in complex with Oligomycin A
To Be Published
4WNV
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Human Cytochrome P450 2D6 Quinine Complex
分子名称: Cytochrome P450 2D6, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Wang, A, Stout, C.D, Johnson, E.F.
登録日2014-10-14
公開日2015-01-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding.
J.Biol.Chem., 290, 2015
4WPD
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X-ray Crystal Structure of CYP119 complexed with 4-(4-flourophenyl)-1H-imidazole
分子名称: 4-(4-fluorophenyl)-1H-imidazole, Cytochrome P450 119, PROTOPORPHYRIN IX CONTAINING FE
著者Madrona, Y.
登録日2014-10-17
公開日2015-02-18
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.001 Å)
主引用文献TWO DIMENTIONAL NMR AND X-RAY ANALYSIS OF CYP119 LIGAND DEPENDENT CONFORMATIONAL DYNAMICS
To Be Published
4WMZ
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S. cerevisiae CYP51 complexed with fluconazole in the active site
分子名称: 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE
著者Sagatova, A, Keniya, M.V, Wilson, R, Wilbanks, S.M, Monk, B.C, Tyndall, J.D.A.
登録日2014-10-09
公開日2015-07-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14 alpha-Demethylase.
Antimicrob.Agents Chemother., 59, 2015
4WNU
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Human Cytochrome P450 2D6 Quinidine Complex
分子名称: Cytochrome P450 2D6, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者Wang, A, Stout, C.D, Johnson, E.F.
登録日2014-10-14
公開日2015-01-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding.
J.Biol.Chem., 290, 2015
4WQJ
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Crystal Structure of CYP119 from Sulfolobus acidocaldarius, Collected at 298K and Complexed with 4-(4-bromophenyl)-1H imidazole
分子名称: 4-(4-bromophenyl)-1H-imidazole, Cytochrome P450 119, GLYCEROL, ...
著者Madrona, Y.
登録日2014-10-22
公開日2015-02-18
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献TWO DIMENSIONAL NMR AND X-RAY ANALYSIS OF CYP119 LIGAND-DEPENDENT CONFORMATIONAL DYNAMICS.
To Be Published
6XA2
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Structure of the tirandamycin C-bound P450 monooxygenase TamI
分子名称: (3E)-3-{(2E,4E,6R)-1-hydroxy-4-methyl-6-[(1R,3R,4S,5R)-1,4,8-trimethyl-2,9-dioxabicyclo[3.3.1]non-7-en-3-yl]hepta-2,4-dien-1-ylidene}-2H-pyrrole-2,4(3H)-dione, PROTOPORPHYRIN IX CONTAINING FE, TamI
著者Newmister, S.A, Srivastava, K.R, Espinoza, R.V, Haatveit, K.C, Khatri, Y, Martini, R.M, Garcia-Borras, M, Podust, L.M, Houk, K.N, Sherman, D.H.
登録日2020-06-03
公開日2021-06-09
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.64 Å)
主引用文献Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway.
Acs Catalysis, 10, 2020
6XA3
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Structure of the ligand free P450 monooxygenase TamI
分子名称: PROTOPORPHYRIN IX CONTAINING FE, TamI
著者Newmister, S.A, Srivastava, K.R, Espinoza, R.V, Haatveit, K.C, Khatri, Y, Martini, R.M, Garcia-Borras, M, Podust, L.M, Houk, K.N, Sherman, D.H.
登録日2020-06-03
公開日2021-06-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.96 Å)
主引用文献Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway.
Acs Catalysis, 10, 2020
4XE3
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OleP, the cytochrome P450 epoxidase from Streptomyces antibioticus involved in Oleandomycin biosynthesis: functional analysis and crystallographic structure in complex with clotrimazole.
分子名称: 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, Cytochrome P-450, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Montemiglio, L.C, Parisi, G, Scaglione, A, Savino, C, Vallone, B.
登録日2014-12-22
公開日2015-11-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Functional analysis and crystallographic structure of clotrimazole bound OleP, a cytochrome P450 epoxidase from Streptomyces antibioticus involved in oleandomycin biosynthesis.
Biochim.Biophys.Acta, 1860, 2015
6XZ8
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Structure of aldosterone synthase (CYP11B2) in complex with N-[(1R)-1-[5-(6-chloro-1,1-dimethyl-3-oxo-isoindolin-2-yl)-3-pyridyl]ethyl]methanesulfonamide
分子名称: Cytochrome P450 11B2, mitochondrial, HEME C, ...
著者Kuglstatter, A, Joseph, C, Benz, J.
登録日2020-02-03
公開日2020-06-24
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.
J.Med.Chem., 63, 2020
6WE6
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Camphor bound P450cam D251E structure
分子名称: CAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ...
著者Amaya, J.A, Poulos, T.L, Batabyal, D.
登録日2020-04-01
公開日2020-07-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Proton Relay Network in the Bacterial P450s: CYP101A1 and CYP101D1.
Biochemistry, 59, 2020

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件を2024-06-26に公開中

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