5ESE

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G73R mutant complexed with fluconazole

Summary for 5ESE

Entry DOI	10.2210/pdb5ese/pdb
Related	5ESF 5ESG 5ESH 5ESI 5ESJ 5ESK 5ESL 5ESM 5ESN
Descriptor	Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, ... (4 entities in total)
Functional Keywords	cyp51, oxidoreductase-oxidoreductase inhibitor complex, mutation, g73r, oxidoreductase/oxidoreductase inhibitor
Biological source	Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Total number of polymer chains	1
Total formula weight	62908.11
Authors	Sagatova, A.,Keniya, M.V.,Wilson, R.K.,Sabherwal, M.,Tyndall, J.D.A.,Monk, B.C. (deposition date: 2015-11-16, release date: 2016-11-23, Last modification date: 2023-09-27)
Primary citation	Sagatova, A.A.,Keniya, M.V.,Tyndall, J.D.A.,Monk, B.C. Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14 alpha-Demethylase. Antimicrob.Agents Chemother., 62:-, 2018 Cited by PubMed: 29263059 DOI: 10.1128/AAC.02242-17 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation