Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5ESG

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G73E mutant complexed with itraconazole

Summary for 5ESG
Entry DOI10.2210/pdb5esg/pdb
Related5ESE 5ESF 5ESH 5ESI 5ESJ 5ESK 5ESL 5ESM 5ESN
DescriptorLanosterol 14-alpha demethylase, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total)
Functional Keywordscyp51, oxidoreductase-oxidoreducatse inhibitor complex, mutation, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceSaccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Total number of polymer chains1
Total formula weight63279.39
Authors
Sagatova, A.,Keniya, M.V.,Wilson, R.K.,Sabherwal, M.,Tyndall, J.D.A.,Monk, B.C. (deposition date: 2015-11-16, release date: 2016-11-23, Last modification date: 2023-09-27)
Primary citationSagatova, A.A.,Keniya, M.V.,Tyndall, J.D.A.,Monk, B.C.
Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14 alpha-Demethylase.
Antimicrob.Agents Chemother., 62:-, 2018
Cited by
PubMed: 29263059
DOI: 10.1128/AAC.02242-17
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.981 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon