4BDQ
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![BU of 4bdq by Molmil](/molmil-images/mine/4bdq) | Crystal structure of the GluK2 R775A LBD dimer in complex with glutamate | 分子名称: | GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2, GLUTAMIC ACID, ... | 著者 | Nayeem, N, Mayans, O, Green, T. | 登録日 | 2012-10-05 | 公開日 | 2013-04-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Correlating Efficacy and Desensitization with Gluk2 Ligand-Binding Domain Movements. Open Biol., 3, 2013
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4BDN
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![BU of 4bdn by Molmil](/molmil-images/mine/4bdn) | Crystal structure of the GluK2 K531A-T779G LBD dimer in complex with glutamate | 分子名称: | GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2, GLUTAMIC ACID, ... | 著者 | Nayeem, N, Mayans, O, Green, T. | 登録日 | 2012-10-05 | 公開日 | 2013-04-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Correlating Efficacy and Desensitization with Gluk2 Ligand-Binding Domain Movements. Open Biol., 3, 2013
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4E0W
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![BU of 4e0w by Molmil](/molmil-images/mine/4e0w) | Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with kainate | 分子名称: | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, Glutamate receptor, ... | 著者 | Venskutonyte, R, Frydenvang, K, Kastrup, J.S. | 登録日 | 2012-03-05 | 公開日 | 2012-05-02 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.3501 Å) | 主引用文献 | Kainate induces various domain closures in AMPA and kainate receptors. Neurochem Int, 61, 2012
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4E0X
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![BU of 4e0x by Molmil](/molmil-images/mine/4e0x) | |
5L1G
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![BU of 5l1g by Molmil](/molmil-images/mine/5l1g) | AMPA subtype ionotropic glutamate receptor GluA2 in complex with GYKI-Br | 分子名称: | (8R)-5-(4-amino-3-bromophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2 | 著者 | Yelshanskaya, M.V, Singh, A.K, Sampson, J.M, Sobolevsky, A.I. | 登録日 | 2016-07-29 | 公開日 | 2016-10-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (4.507 Å) | 主引用文献 | Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs. Neuron, 91, 2016
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5YBF
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![BU of 5ybf by Molmil](/molmil-images/mine/5ybf) | Crystal structure of the GluA2o LBD in complex with glutamate and HBT1 | 分子名称: | 2-[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanoylamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, ACETATE ION, GLUTAMIC ACID, ... | 著者 | Sogabe, S, Igaki, S, Hirokawa, A, Zama, Y, Lane, W, Snell, G. | 登録日 | 2017-09-04 | 公開日 | 2018-01-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production. J. Pharmacol. Exp. Ther., 364, 2018
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5MFW
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![BU of 5mfw by Molmil](/molmil-images/mine/5mfw) | Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-121 at 2.10 A resolution | 分子名称: | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, 7-chloro-4-(2-fluoroethyl)-2,3-dihydro-1,2,4-benzothiadiazine 1,1-dioxide, ACETATE ION, ... | 著者 | Larsen, A.P, Frydenvang, K, Kastrup, J.S. | 登録日 | 2016-11-18 | 公開日 | 2017-04-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Mol. Pharmacol., 91, 2017
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5MFQ
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![BU of 5mfq by Molmil](/molmil-images/mine/5mfq) | Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-344 at 1.90 A resolution | 分子名称: | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, CHLORIDE ION, ... | 著者 | Larsen, A.P, Frydenvang, K, Kastrup, J.S. | 登録日 | 2016-11-18 | 公開日 | 2017-04-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Mol. Pharmacol., 91, 2017
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5YBG
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![BU of 5ybg by Molmil](/molmil-images/mine/5ybg) | Crystal structure of the GluA2o LBD in complex with glutamate and LY451395 | 分子名称: | ACETATE ION, GLUTAMIC ACID, GLYCEROL, ... | 著者 | Sogabe, S, Igaki, S, Hirokawa, A, Zama, Y, Lane, W, Snell, G. | 登録日 | 2017-09-04 | 公開日 | 2018-01-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production. J. Pharmacol. Exp. Ther., 364, 2018
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5M2V
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![BU of 5m2v by Molmil](/molmil-images/mine/5m2v) | Structure of GluK1 ligand-binding domain (S1S2) in complex with (2S,4R)-4-(2-carboxyphenoxy)pyrrolidine-2-carboxylic acid at 3.18 A resolution | 分子名称: | (2~{S},4~{R})-4-(2-carboxyphenoxy)pyrrolidine-2-carboxylic acid, CHLORIDE ION, Glutamate receptor ionotropic, ... | 著者 | Frydenvang, K, Kastrup, J.S, Kristensen, C.M. | 登録日 | 2016-10-13 | 公開日 | 2017-01-11 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | 主引用文献 | Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid. J. Med. Chem., 60, 2017
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5ZG3
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![BU of 5zg3 by Molmil](/molmil-images/mine/5zg3) | Crystal structure of the GluA2o LBD in complex with glutamate and TAK-137 | 分子名称: | 9-(4-phenoxyphenyl)-3,4-dihydro-2H-2lambda~6~-pyrido[2,1-c][1,2,4]thiadiazine-2,2-dione, ACETATE ION, GLUTAMIC ACID, ... | 著者 | Sogabe, S, Igaki, S, Hirokawa, A, Zama, Y, Lane, W, Snell, G. | 登録日 | 2018-03-07 | 公開日 | 2019-01-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window. Neuropsychopharmacology, 44, 2019
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5MFV
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![BU of 5mfv by Molmil](/molmil-images/mine/5mfv) | Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-521 at 2.18 A resolution | 分子名称: | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, 4-Cyclopropyl-3,4-dihydro-7-hydroxy-2H-1,2,4-benzothiadiazine 1,1-dioxide, ACETATE ION, ... | 著者 | Larsen, A.P, Frydenvang, K, Kastrup, J.S. | 登録日 | 2016-11-18 | 公開日 | 2017-04-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.181 Å) | 主引用文献 | Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Mol. Pharmacol., 91, 2017
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5NF6
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![BU of 5nf6 by Molmil](/molmil-images/mine/5nf6) | Structure of GluK3 ligand-binding domain (S1S2) in complex with CIP-AS at 2.55 A resolution | 分子名称: | (3~{a}~{S},4~{S},6~{a}~{R})-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-d][1,2]oxazole-3,4-dicarboxylic acid, ACETATE ION, CHLORIDE ION, ... | 著者 | Frydenvang, K, Venskutonyte, R, Thorsen, T.S, Kastrup, J.S. | 登録日 | 2017-03-13 | 公開日 | 2017-07-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors. ACS Chem Neurosci, 8, 2017
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5WEN
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![BU of 5wen by Molmil](/molmil-images/mine/5wen) | GluA2 bound to GSG1L in digitonin, state 2 | 分子名称: | Digitonin, Glutamate receptor 2,Germ cell-specific gene 1-like protein | 著者 | Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. | 登録日 | 2017-07-10 | 公開日 | 2017-08-02 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (6.8 Å) | 主引用文献 | Channel opening and gating mechanism in AMPA-subtype glutamate receptors. Nature, 549, 2017
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5ZG1
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![BU of 5zg1 by Molmil](/molmil-images/mine/5zg1) | Crystal structure of the GluA2o LBD in complex with glutamate and Compound-2 | 分子名称: | 9-(4-~{tert}-butylphenyl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide, GLUTAMIC ACID, GLYCEROL, ... | 著者 | Sogabe, S, Igaki, S, Hirokawa, A, Zama, Y, Lane, W, Snell, G. | 登録日 | 2018-03-07 | 公開日 | 2019-01-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window. Neuropsychopharmacology, 44, 2019
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5ZG2
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![BU of 5zg2 by Molmil](/molmil-images/mine/5zg2) | Crystal structure of the GluA2o LBD in complex with ZK200775 and Compound-2 | 分子名称: | 9-(4-~{tert}-butylphenyl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide, ACETATE ION, GLYCEROL, ... | 著者 | Sogabe, S, Igaki, S, Hirokawa, A, Zama, Y, Lane, W, Snell, G. | 登録日 | 2018-03-07 | 公開日 | 2019-01-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window. Neuropsychopharmacology, 44, 2019
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5NIH
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![BU of 5nih by Molmil](/molmil-images/mine/5nih) | Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist LM-12b at 1.3 A resolution. | 分子名称: | (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid, ACETATE ION, CHLORIDE ION, ... | 著者 | Laulumaa, S, Frydenvang, K.A, Kastrup, J.S. | 登録日 | 2017-03-24 | 公開日 | 2017-07-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors. ACS Chem Neurosci, 8, 2017
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5NEB
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![BU of 5neb by Molmil](/molmil-images/mine/5neb) | Structure of GluK1 ligand-binding domain (S1S2) in complex with LM-12b at 2.05 A resolution | 分子名称: | (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid, ACETATE ION, CHLORIDE ION, ... | 著者 | Moellerud, S, Frydenvang, K, Laulumaa, S, Kastrup, J.S. | 登録日 | 2017-03-10 | 公開日 | 2017-07-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors. ACS Chem Neurosci, 8, 2017
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5NG9
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![BU of 5ng9 by Molmil](/molmil-images/mine/5ng9) | Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist CIP-AS at 1.15 A resolution. | 分子名称: | (2~{S},3~{R},4~{R})-3-(carboxycarbonyl)-4-oxidanyl-pyrrolidine-2-carboxylic acid, (3~{a}~{S},4~{S},6~{a}~{R})-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-d][1,2]oxazole-3,4-dicarboxylic acid, CITRATE ANION, ... | 著者 | Laulumaa, S, Frydenvang, K.A, Winther, S, Kastrup, J.S. | 登録日 | 2017-03-17 | 公開日 | 2017-07-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors. ACS Chem Neurosci, 8, 2017
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5WEO
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![BU of 5weo by Molmil](/molmil-images/mine/5weo) | Activated GluA2 complex bound to glutamate, cyclothiazide, and STZ in digitonin | 分子名称: | CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit chimera | 著者 | Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. | 登録日 | 2017-07-10 | 公開日 | 2017-08-02 | 最終更新日 | 2019-11-20 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Channel opening and gating mechanism in AMPA-subtype glutamate receptors. Nature, 549, 2017
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5NF5
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![BU of 5nf5 by Molmil](/molmil-images/mine/5nf5) | Structure of GluK1 ligand-binding domain (S1S2) in complex with CIP-AS at 2.85 A resolution | 分子名称: | (3~{a}~{S},4~{S},6~{a}~{R})-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-d][1,2]oxazole-3,4-dicarboxylic acid, CHLORIDE ION, GLYCEROL, ... | 著者 | Frydenvang, K, Venskutonyte, R, Thorsen, T.S, Kastrup, J.S. | 登録日 | 2017-03-13 | 公開日 | 2017-07-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors. ACS Chem Neurosci, 8, 2017
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5ZG0
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![BU of 5zg0 by Molmil](/molmil-images/mine/5zg0) | Crystal structure of the GluA2o LBD in complex with glutamate and Compound-1 | 分子名称: | 9-{4-[(propan-2-yl)oxy]phenyl}-3,4-dihydro-2H-2lambda~6~-pyrido[2,1-c][1,2,4]thiadiazine-2,2-dione, ACETATE ION, GLUTAMIC ACID, ... | 著者 | Sogabe, S, Igaki, S, Hirokawa, A, Zama, Y, Lane, W, Snell, G. | 登録日 | 2018-03-07 | 公開日 | 2019-01-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window. Neuropsychopharmacology, 44, 2019
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5WEM
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![BU of 5wem by Molmil](/molmil-images/mine/5wem) | GluA2 bound to GSG1L in digitonin, state 1 | 分子名称: | Chimera of Glutamate receptor 2,Germ cell-specific gene 1-like protein | 著者 | Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. | 登録日 | 2017-07-10 | 公開日 | 2017-08-02 | 最終更新日 | 2019-11-20 | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | 主引用文献 | Channel opening and gating mechanism in AMPA-subtype glutamate receptors. Nature, 549, 2017
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5WEL
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![BU of 5wel by Molmil](/molmil-images/mine/5wel) | GluA2 bound to antagonist ZK and GSG1L in digitonin, state 2 | 分子名称: | Chimera of Glutamate receptor 2, Germ cell-specific gene 1-like protein, Digitonin, ... | 著者 | Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. | 登録日 | 2017-07-10 | 公開日 | 2017-08-02 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Channel opening and gating mechanism in AMPA-subtype glutamate receptors. Nature, 549, 2017
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1PB8
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![BU of 1pb8 by Molmil](/molmil-images/mine/1pb8) | |