Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 672 件
5O9A
DownloadVisualize
BU of 5o9a by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J-L504Y-N775S) in complex with glutamate and BPAM121 at 1.78 A resolution
分子名称: 1,2-ETHANEDIOL, 7-chloro-4-(2-fluoroethyl)-2,3-dihydro-1,2,4-benzothiadiazine 1,1-dioxide, CHLORIDE ION, ...
著者Laulumaa, S, Rovinskaja, K, Frydenvang, K.A, Kastrup, J.S.
登録日2017-06-16
公開日2018-01-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency.
J. Med. Chem., 61, 2018
5OEW
DownloadVisualize
BU of 5oew by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with glutamate and positive allosteric modulator BPAM538
分子名称: 4-cyclopropyl-7-(3-methoxyphenoxy)-2,3-dihydro-1$l^{6},2,4-benzothiadiazine 1,1-dioxide, ACETATE ION, GLUTAMIC ACID, ...
著者Larsen, A.P, Frydenvang, K.A, Kastrup, J.S.
登録日2017-07-10
公開日2018-01-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency.
J. Med. Chem., 61, 2018
1GR2
DownloadVisualize
BU of 1gr2 by Molmil
STRUCTURE OF A GLUTAMATE RECEPTOR LIGAND BINDING CORE (GLUR2) COMPLEXED WITH KAINATE
分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, PROTEIN (GLUTAMATE RECEPTOR 2)
著者Armstrong, N, Sun, Y, Chen, G.Q, Gouaux, E.
登録日1998-09-17
公開日1998-12-09
最終更新日2017-08-16
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of a glutamate-receptor ligand-binding core in complex with kainate.
Nature, 395, 1998
1II5
DownloadVisualize
BU of 1ii5 by Molmil
CRYSTAL STRUCTURE OF THE GLUR0 LIGAND BINDING CORE COMPLEX WITH L-GLUTAMATE
分子名称: GLUTAMIC ACID, Slr1257 protein
著者Mayer, M.L, Olson, R, Gouaux, E.
登録日2001-04-20
公開日2001-09-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Mechanisms for ligand binding to GluR0 ion channels: crystal structures of the glutamate and serine complexes and a closed apo state.
J.Mol.Biol., 311, 2001
5NS9
DownloadVisualize
BU of 5ns9 by Molmil
Crystal structure of the GluA2 LBD (L483Y-N754S-L758V) in complex with glutamate
分子名称: 2-(2-METHOXYETHOXY)ETHANOL, GLUTAMIC ACID, Glutamate receptor 2,Glutamate receptor 2, ...
著者Eibl, C, Plested, A.J.R.
登録日2017-04-25
公開日2017-09-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.44 Å)
主引用文献Unitary Properties of AMPA Receptors with Reduced Desensitization.
Biophys. J., 113, 2017
9B39
DownloadVisualize
BU of 9b39 by Molmil
Kainate receptor GluK2 in complex with agonist glutamate with asymmetric ligand-binding domain layer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ...
著者Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I.
登録日2024-03-18
公開日2024-05-22
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.84 Å)
主引用文献Kainate receptor channel opening and gating mechanism.
Nature, 630, 2024
9B35
DownloadVisualize
BU of 9b35 by Molmil
Ligand-binding and transmembrane domains of kainate receptor GluK2 in the open state, a complex with agonist glutamate and positive allosteric modulator BPAM344
分子名称: GLUTAMIC ACID, Glutamate receptor ionotropic, kainate 2
著者Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I.
登録日2024-03-18
公開日2024-05-22
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Kainate receptor channel opening and gating mechanism.
Nature, 630, 2024
1FTK
DownloadVisualize
BU of 1ftk by Molmil
CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2I) IN COMPLEX WITH KAINATE AT 1.6 A RESOLUTION
分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, GLUTAMATE RECEPTOR SUBUNIT 2
著者Gouaux, E, Armstrong, N.
登録日2000-09-12
公開日2000-11-01
最終更新日2017-08-02
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Neuron, 28, 2000
9B37
DownloadVisualize
BU of 9b37 by Molmil
Open state of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to one concanavalin A dimer. Composite map.
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I.
登録日2024-03-18
公開日2024-05-22
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (6.66 Å)
主引用文献Kainate receptor channel opening and gating mechanism.
Nature, 630, 2024
9B36
DownloadVisualize
BU of 9b36 by Molmil
Open state of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to two concanavalin A dimers. Composite map.
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I.
登録日2024-03-18
公開日2024-05-22
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (4.29 Å)
主引用文献Kainate receptor channel opening and gating mechanism.
Nature, 630, 2024
9B38
DownloadVisualize
BU of 9b38 by Molmil
Kainate receptor GluK2 in complex with agonist glutamate with pseudo 4-fold symmetrical ligand-binding domain layer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ...
著者Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I.
登録日2024-03-18
公開日2024-05-22
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.36 Å)
主引用文献Kainate receptor channel opening and gating mechanism.
Nature, 630, 2024
3U92
DownloadVisualize
BU of 3u92 by Molmil
Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2221 form
分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, Glutamate receptor, ...
著者Kumar, J, Mayer, M.L.
登録日2011-10-17
公開日2012-09-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface.
Neuron, 76, 2012
1FTM
DownloadVisualize
BU of 1ftm by Molmil
CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH AMPA AT 1.7 RESOLUTION
分子名称: (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID, GLUTAMATE RECEPTOR SUBUNIT 2, ZINC ION
著者Gouaux, E, Armstrong, N.
登録日2000-09-12
公開日2000-11-01
最終更新日2017-08-02
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Neuron, 28, 2000
1FW0
DownloadVisualize
BU of 1fw0 by Molmil
CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH KAINATE AT 2.0 A RESOLUTION
分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, GLUTAMATE RECEPTOR SUBUNIT 2
著者Armstrong, N, Gouaux, E.
登録日2000-09-20
公開日2000-11-15
最終更新日2017-08-02
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Neuron, 28, 2000
1FTO
DownloadVisualize
BU of 1fto by Molmil
CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN THE APO STATE AT 2.0 A RESOLUTION
分子名称: GLUTAMATE RECEPTOR SUBUNIT 2
著者Armstrong, N, Gouaux, E.
登録日2000-09-12
公開日2000-11-01
最終更新日2017-08-02
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Neuron, 28, 2000
3TZA
DownloadVisualize
BU of 3tza by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid at 1.9A resolution
分子名称: (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid, Glutamate receptor 2,Glutamate receptor 2, SULFATE ION
著者Frydenvang, K, Kastrup, J.S.
登録日2011-09-27
公開日2011-10-26
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure
J.Med.Chem., 54, 2011
3U94
DownloadVisualize
BU of 3u94 by Molmil
Crystal structure of the GluK3 ligand binding domain complex with glutamate and zinc: P21212 form
分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ...
著者Kumar, J, Mayer, M.L.
登録日2011-10-17
公開日2012-09-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.962 Å)
主引用文献Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface.
Neuron, 76, 2012
3U93
DownloadVisualize
BU of 3u93 by Molmil
Crystal structure of the GluK3 ligand binding domain complex with glutamate and zinc: P2221 form
分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ...
著者Kumar, J, Mayer, M.L.
登録日2011-10-17
公開日2012-09-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.881 Å)
主引用文献Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface.
Neuron, 76, 2012
1FTL
DownloadVisualize
BU of 1ftl by Molmil
CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH THE ANTAGONIST DNQX AT 1.8 A RESOLUTION
分子名称: 6,7-DINITROQUINOXALINE-2,3-DIONE, GLUTAMATE RECEPTOR SUBUNIT 2, SULFATE ION
著者Armstrong, N, Gouaux, E.
登録日2000-09-12
公開日2000-11-01
最終更新日2017-08-02
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Neuron, 28, 2000
7OCA
DownloadVisualize
BU of 7oca by Molmil
Resting state full-length GluA1/A2 heterotertramer in complex with TARP gamma 8 and CNIH2
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H.
登録日2021-04-26
公開日2021-06-09
最終更新日2021-06-30
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Nature, 594, 2021
7OCC
DownloadVisualize
BU of 7occ by Molmil
NTD of resting state GluA1/A2 heterotertramer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 1, ...
著者Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H.
登録日2021-04-26
公開日2021-06-09
最終更新日2021-06-30
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Nature, 594, 2021
7OCD
DownloadVisualize
BU of 7ocd by Molmil
Resting state GluA1/A2 heterotetramer in complex with auxiliary subunit TARP gamma 8 (LBD-TMD)
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, Glutamate receptor 2, ...
著者Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H.
登録日2021-04-26
公開日2021-06-09
最終更新日2021-06-30
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Nature, 594, 2021
7OCE
DownloadVisualize
BU of 7oce by Molmil
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD)
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, CHOLESTEROL, ...
著者Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H.
登録日2021-04-26
公開日2021-06-09
最終更新日2021-06-30
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Nature, 594, 2021
7OCF
DownloadVisualize
BU of 7ocf by Molmil
Active state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD)
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CYCLOTHIAZIDE, GLUTAMIC ACID, ...
著者Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H.
登録日2021-04-26
公開日2021-06-09
最終更新日2021-06-30
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Nature, 594, 2021
3TKD
DownloadVisualize
BU of 3tkd by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and cyclothiazide at 1.45 A resolution
分子名称: CYCLOTHIAZIDE, GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, ...
著者Krintel, C, Frydenvang, K, Gajhede, M, Kastrup, J.S.
登録日2011-08-26
公開日2011-09-21
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2.
Biochem.J., 441, 2012

223166

件を2024-07-31に公開中

PDB statisticsPDBj update infoContact PDBjnumon