6YK4

Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound ( S) - 1- [2'-Amino-2'-carboxyethyl]-6-methyl-5 ,7- dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 1.00A

Summary for 6YK4

Entry DOI	10.2210/pdb6yk4/pdb
Descriptor	Glutamate receptor 2,Glutamate receptor 2, SULFATE ION, GLYCEROL, ... (7 entities in total)
Functional Keywords	ionotropic glutamate receptor, glua2o ligand-binding domain, bicyclic pyrimidinedione analogue, membrane protein
Biological source	Rattus norvegicus (Norway Rat) More
Total number of polymer chains	1
Total formula weight	30363.45
Authors	Frydenvang, K.,Kastrup, J.S. (deposition date: 2020-04-05, release date: 2020-06-03, Last modification date: 2024-01-24)
Primary citation	Frydenvang, K.,Pickering, D.S.,Kshirsagar, G.U.,Chemi, G.,Gemma, S.,Sprogoe, D.,Kærn, A.M.,Brogi, S.,Campiani, G.,Butini, S.,Kastrup, J.S. Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions. Acs Chem Neurosci, 11:1791-1800, 2020 Cited by PubMed: 32437601 DOI: 10.1021/acschemneuro.0c00195 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (0.999 Å)

Structure validation