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PDB: 672 件
3OEM
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Crystal structure of GluN2D ligand-binding core in complex with N-methyl-D-aspartate
分子名称: Glutamate [NMDA] receptor subunit epsilon-4, N-methyl-D-aspartic acid
著者Simorowski, N, Furukawa, H.
登録日2010-08-12
公開日2011-05-11
最終更新日2017-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.
Nat Commun, 2, 2011
3O29
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Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator
分子名称: GLUTAMIC ACID, GLYCEROL, Glutamate receptor 2, ...
著者Maclean, J.K.F, Basten, S, Campbell, R.A, Cumming, I.A, Gillen, K.J, Gillespie, J, Jamieson, C, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Papakosta, M, Rankovic, Z, Smith, L.
登録日2010-07-22
公開日2010-09-15
最終更新日2017-08-09
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies.
Bioorg.Med.Chem.Lett., 20, 2010
3O28
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Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator
分子名称: 2-({[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ...
著者Maclean, J.K.F, Basten, S, Campbell, R.A, Cumming, I.A, Gillen, K.J, Gillespie, J, Jamieson, C, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Papakosta, M, Rankovic, Z, Smith, L.
登録日2010-07-22
公開日2010-09-15
最終更新日2017-08-09
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies.
Bioorg.Med.Chem.Lett., 20, 2010
3O6H
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Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator
分子名称: 1,2-ETHANEDIOL, 2-[({4-[(ethylamino)methyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}acetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, DIMETHYL SULFOXIDE, ...
著者Maclean, J.K.F, Campbell, R.A, Cumming, I.A, Gillen, K.J, Gillespie, J, Jamieson, C, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Martin, F, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L.
登録日2010-07-29
公開日2010-09-15
最終更新日2017-08-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A novel series of positive modulators of the AMPA receptor: structure-based lead optimization.
Bioorg.Med.Chem.Lett., 20, 2010
3O6G
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Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator
分子名称: 1,2-ETHANEDIOL, GLUTAMIC ACID, Glutamate receptor 2, ...
著者Maclean, J.K.F, Campbell, R.A, Cumming, I.A, Gillen, K.J, Gillespie, J, Jamieson, C, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Martin, F, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L.
登録日2010-07-29
公開日2010-09-15
最終更新日2017-08-09
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A novel series of positive modulators of the AMPA receptor: structure-based lead optimization.
Bioorg.Med.Chem.Lett., 20, 2010
3OEL
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Crystal structure of GluN2D ligand-binding core in complex with D-glutamate
分子名称: D-GLUTAMIC ACID, Glutamate [NMDA] receptor subunit epsilon-4
著者Simorowski, N, Furukawa, H.
登録日2010-08-12
公開日2011-05-11
最終更新日2017-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.
Nat Commun, 2, 2011
3OEK
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Crystal structure of GluN2D ligand-binding core in complex with L-aspartate
分子名称: ASPARTIC ACID, Glutamate [NMDA] receptor subunit epsilon-4
著者Simorowski, N, Furukawa, H.
登録日2010-08-12
公開日2011-05-11
最終更新日2017-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.
Nat Commun, 2, 2011
6LU9
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Rat ionotropic Glutamate Delta-2 receptor in complex with 7-CKA and Calcium
分子名称: Glutamate receptor ionotropic, delta-2
著者Kumar, J, Burada, A.P.
登録日2020-01-27
公開日2020-06-17
最終更新日2020-12-30
実験手法ELECTRON MICROSCOPY (8.8 Å)
主引用文献The architecture of GluD2 ionotropic delta glutamate receptor elucidated by cryo-EM.
J.Struct.Biol., 211, 2020
6MMR
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Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, 3 millimolar EDTA, and at pH 7.4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ...
著者Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
登録日2018-10-01
公開日2018-11-28
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (5.13 Å)
主引用文献Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMB
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Diheteromeric NMDA receptor GluN1/GluN2A in the 'Super-Splayed' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 6.1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ...
著者Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
登録日2018-09-30
公開日2018-11-28
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (12.7 Å)
主引用文献Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMS
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Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar EDTA, and at pH 7.4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
登録日2018-10-01
公開日2018-11-28
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (5.38 Å)
主引用文献Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMV
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Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* Extracellular Domain in the '2-Knuckle-Asymmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
登録日2018-10-01
公開日2018-11-28
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4.71 Å)
主引用文献Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMN
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BU of 6mmn by Molmil
Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 8.0
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
登録日2018-10-01
公開日2018-11-28
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (7.51 Å)
主引用文献Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMG
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Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar EDTA, and at pH 7.4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
登録日2018-09-30
公開日2018-11-28
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (6.23 Å)
主引用文献Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMX
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Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the 'Extended' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
登録日2018-10-01
公開日2018-11-28
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (6.99 Å)
主引用文献Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMJ
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Diheteromeric NMDA receptor GluN1/GluN2A in the 'Super-Splayed' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, and at pH 7.4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ...
著者Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
登録日2018-09-30
公開日2018-11-28
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (16.5 Å)
主引用文献Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMK
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Diheteromeric NMDA receptor GluN1/GluN2A in the '1-Knuckle' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
登録日2018-09-30
公開日2018-11-28
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (6.08 Å)
主引用文献Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMH
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Diheteromeric NMDA receptor GluN1/GluN2A in the 'Extended-2' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, and at pH 7.4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ...
著者Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
登録日2018-09-30
公開日2018-11-28
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (8.21 Å)
主引用文献Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMW
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Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
登録日2018-10-01
公開日2018-11-28
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (6.2 Å)
主引用文献Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMA
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Diheteromeric NMDA receptor GluN1/GluN2A in the 'Extended' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 6.1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ...
著者Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
登録日2018-09-29
公開日2018-11-28
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (6.31 Å)
主引用文献Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMT
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Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '1-Knuckle' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
登録日2018-10-01
公開日2018-11-28
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (7.46 Å)
主引用文献Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MML
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Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Asymmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
登録日2018-09-30
公開日2018-11-28
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (7.14 Å)
主引用文献Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMP
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Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 0.1 millimolar EDTA, and at pH 8.0
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
登録日2018-10-01
公開日2018-11-28
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (6.88 Å)
主引用文献Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMM
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Diheteromeric NMDA receptor GluN1/GluN2A in the 'Extended-1' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
登録日2018-09-30
公開日2018-11-28
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (6.84 Å)
主引用文献Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMI
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Diheteromeric NMDA receptor GluN1/GluN2A in the 'Splayed-Open' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, and at pH 7.4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
登録日2018-09-30
公開日2018-11-28
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (8.93 Å)
主引用文献Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018

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