6MML

Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Asymmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4

Summary for 6MML

Entry DOI	10.2210/pdb6mml/pdb
EMDB information	9147 9148 9149 9150 9151 9152 9153 9154 9155 9156 9157 9158 9159 9160 9161 9162 9163 9164 9165
Descriptor	Glutamate receptor ionotropic, NMDA 1, Glutamate receptor ionotropic, NMDA 2A, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	ligand-gated ion channel, nmda receptor, ionotropic glutamate receptors, membrane protein, transport protein
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	4
Total formula weight	384194.11
Authors	Jalali-Yazdi, F.,Chowdhury, S.,Yoshioka, C.,Gouaux, E. (deposition date: 2018-09-30, release date: 2018-11-28, Last modification date: 2020-07-29)
Primary citation	Jalali-Yazdi, F.,Chowdhury, S.,Yoshioka, C.,Gouaux, E. Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175:1520-1532.e15, 2018 Cited by PubMed: 30500536 DOI: 10.1016/j.cell.2018.10.043 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (7.14 Å)

Structure validation