6MML
Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Asymmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0038023 | molecular_function | signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0038023 | molecular_function | signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0038023 | molecular_function | signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0038023 | molecular_function | signaling receptor activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1404 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| B | GLN23-ALA555 | |
| B | THR646-ASN816 | |
| D | GLN23-ALA555 | |
| D | THR646-ASN816 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 118 |
| Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:B7ZSK1 |
| Chain | Residue | Details |
| B | SER556-PHE576 | |
| B | THR626-TYR645 | |
| B | MET817-TRP837 | |
| D | SER556-PHE576 | |
| D | THR626-TYR645 | |
| D | MET817-TRP837 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 54 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| B | GLU577-THR600 | |
| B | ASN621-THR625 | |
| D | GLU577-THR600 | |
| D | ASN621-THR625 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 38 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:B7ZSK1 |
| Chain | Residue | Details |
| B | ILE601-GLN620 | |
| D | ILE601-GLN620 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27916457, ECO:0007744|PDB:5TPW |
| Chain | Residue | Details |
| B | HIS44 | |
| B | HIS128 | |
| B | GLU266 | |
| B | ASP282 | |
| D | HIS44 | |
| D | HIS128 | |
| D | GLU266 | |
| D | ASP282 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY |
| Chain | Residue | Details |
| B | SER511 | |
| D | SER511 | |
| A | ASP732 | |
| C | ARG523 | |
| C | SER688 | |
| C | ASP732 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24462099, ECO:0000269|PubMed:27618671, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY |
| Chain | Residue | Details |
| B | ARG518 | |
| D | ARG518 | |
| C | ASN61 | |
| C | ASN239 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24462099, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8 |
| Chain | Residue | Details |
| B | SER689 | |
| B | TYR730 | |
| D | SER689 | |
| D | TYR730 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | SITE: Functional determinant of NMDA receptors => ECO:0000250 |
| Chain | Residue | Details |
| B | ASN614 | |
| D | ASN614 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN75 | |
| D | ASN444 | |
| D | ASN541 | |
| D | ASN687 | |
| B | ASN340 | |
| B | ASN443 | |
| B | ASN444 | |
| B | ASN541 | |
| B | ASN687 | |
| D | ASN75 | |
| D | ASN340 | |
| D | ASN443 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0007744|PubMed:24090084 |
| Chain | Residue | Details |
| A | ASN350 | |
| A | ASN771 | |
| C | ASN350 | |
| C | ASN771 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5, ECO:0007744|PubMed:24090084 |
| Chain | Residue | Details |
| A | ASN440 | |
| C | ASN440 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN471 | |
| A | ASN491 | |
| A | ASN674 | |
| C | ASN471 | |
| C | ASN491 | |
| C | ASN674 |
