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PDB: 438 件
6X4X
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B24Y DKP insulin
分子名称: Insulin, Insulin chain A
著者Weiss, M.A, Yang, Y.
登録日2020-05-24
公開日2020-08-05
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Evolution of insulin at the edge of foldability and its medical implications.
Proc.Natl.Acad.Sci.USA, 117, 2020
8GSG
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T3R3 form of Human insulin with single Zn
分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
著者Zhu, Z.L.
登録日2022-09-06
公開日2023-03-15
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献T3R3 insulin with single Zn
To Be Published
9INS
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MONOVALENT CATION BINDING IN CUBIC INSULIN CRYSTALS
分子名称: INSULIN (CHAIN A), INSULIN (CHAIN B)
著者Badger, J, Dodson, G.G.
登録日1991-10-23
公開日1991-11-07
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Monovalent cation binding to cubic insulin crystals
Biophys.J., 61, 1992
6KH9
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Solution structure of bovine insulin amyloid intermediate-1
分子名称: Insulin A chain, Insulin B chain
著者Ratha, B.N, Kar, R.K, Brender, J.B, Bhunia, A.
登録日2019-07-14
公開日2020-08-12
最終更新日2024-10-09
実験手法SOLUTION NMR
主引用文献High-resolution structure of a partially folded insulin aggregation intermediate.
Proteins, 88, 2020
8Z4B
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Crystal structure of LysB22-AspB28 insulin analog at ambient structure
分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
著者Ayan, E, Demirci, H.
登録日2024-04-17
公開日2024-05-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of LysB22-AspB28 insulin analog at ambient structure
To Be Published
6KHA
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Solution structure of bovine insulin amyloid intermediate-2
分子名称: Insulin A chain, Insulin B chain
著者Ratha, B.N, Kar, R.K, Brender, J.B, Bhunia, A.
登録日2019-07-14
公開日2020-08-12
最終更新日2024-10-16
実験手法SOLUTION NMR
主引用文献High-resolution structure of a partially folded insulin aggregation intermediate.
Proteins, 88, 2020
8RVT
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BU of 8rvt by Molmil
Structure of full-length human insulin fibrils
分子名称: Insulin A chain, Insulin B chain
著者Bardiaux, B, Suladze, S, Reif, B.
登録日2024-02-02
公開日2024-05-29
最終更新日2024-06-12
実験手法SOLID-STATE NMR
主引用文献Atomic resolution structure of full-length human insulin fibrils.
Proc.Natl.Acad.Sci.USA, 121, 2024
1CPH
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BU of 1cph by Molmil
CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11
分子名称: 1,2-DICHLOROETHANE, INSULIN (PH 10), SODIUM ION
著者Gursky, O, Badger, J, Li, Y, Caspar, D.L.D.
登録日1992-10-30
公開日1993-01-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Conformational changes in cubic insulin crystals in the pH range 7-11.
Biophys.J., 63, 1992
8RRP
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BU of 8rrp by Molmil
Insulin Icodec - A14E B16H B25H B29Ne-C20 diacid-LgGlu-2xAdo desB30 human insulin
分子名称: ACETATE ION, Insulin, Insulin B chain
著者Schluckebier, G, Johansson, E.
登録日2024-01-23
公開日2024-07-10
最終更新日2024-07-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Enhanced disulphide bond stability contributes to the once-weekly profile of insulin icodec.
Nat Commun, 15, 2024
1SF1
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BU of 1sf1 by Molmil
NMR STRUCTURE OF HUMAN INSULIN under Amyloidogenic Condition, 15 STRUCTURES
分子名称: INSULIN A CHAIN, Insulin
著者Weiss, M.A, Hua, Q.X.
登録日2004-02-19
公開日2004-03-30
最終更新日2022-03-02
実験手法SOLUTION NMR
主引用文献Mechanism of insulin fibrillation: the structure of insulin under amyloidogenic conditions resembles a protein-folding intermediate
J.Biol.Chem., 279, 2004
6K59
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Structure of Glargine insulin in 20% acetic acid-d4 (pH 1.9)
分子名称: Glargine Insulin Chain-A, Glargine insulin Chain-B
著者Ratha, B.N, Kar, R.K, Bhunia, A.
登録日2019-05-28
公開日2020-05-06
実験手法SOLUTION NMR
主引用文献Molecular Details of a Salt Bridge and Its Role in Insulin Fibrillation by NMR and Raman Spectroscopic Analysis.
J.Phys.Chem.B, 124, 2020
1SJU
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BU of 1sju by Molmil
MINI-PROINSULIN, SINGLE CHAIN INSULIN ANALOG MUTANT: DES B30, HIS(B 10)ASP, PRO(B 28)ASP AND PEPTIDE BOND BETWEEN LYS B 29 AND GLY A 1, NMR, 20 STRUCTURES
分子名称: PROINSULIN
著者Hua, Q.X, Hu, S.Q, Jia, W.H, Chu, Y.C, Burke, G.T, Wang, S.H, Katsoyannis, P.G, Weiss, M.A.
登録日1997-10-09
公開日1998-03-18
最終更新日2024-10-16
実験手法SOLUTION NMR
主引用文献Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures.
J.Mol.Biol., 277, 1998
6KH8
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BU of 6kh8 by Molmil
Solution structure of Zn free Bovine Pancreatic Insulin in 20% acetic acid-d4 (pH 1.9)
分子名称: Insulin A Chain, Insulin B chain
著者Bhunia, A, Ratha, B.N, Kar, R.K, Brender, J.R.
登録日2019-07-14
公開日2020-10-07
最終更新日2020-11-18
実験手法SOLUTION NMR
主引用文献High-resolution structure of a partially folded insulin aggregation intermediate.
Proteins, 88, 2020
4P65
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BU of 4p65 by Molmil
Crystal structure of an cyclohexylalanine substituted insulin analog.
分子名称: CHLORIDE ION, Insulin, PHENOL, ...
著者Pandyarajan, V, Wan, Z, Weiss, M.A.
登録日2014-03-21
公開日2014-10-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Aromatic Anchor at an Invariant Hormone-Receptor Interface: FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN.
J.Biol.Chem., 289, 2014
1DPH
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BU of 1dph by Molmil
CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11
分子名称: 1,2-DICHLOROETHANE, INSULIN A CHAIN (PH 11), INSULIN B CHAIN (PH 11), ...
著者Gursky, O, Badger, J, Li, Y, Caspar, D.L.D.
登録日1992-10-30
公開日1993-01-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Conformational changes in cubic insulin crystals in the pH range 7-11.
Biophys.J., 63, 1992
4RXW
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BU of 4rxw by Molmil
Crystal Structure of the cobalt human insulin derivative
分子名称: COBALT (II) ION, Insulin A chain, Insulin B chain
著者Prugovecki, B, Ivetic, N, Matkovic-Calogovic, D.
登録日2014-12-12
公開日2015-01-21
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Crystal Structure of the cobalt human insulin derivative
TO BE PUBLISHED
2RN5
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BU of 2rn5 by Molmil
Humal Insulin Mutant B31Lys-B32Arg
分子名称: Insulin
著者Bocian, W, Kozerski, L.
登録日2007-12-06
公開日2008-10-28
最終更新日2022-03-16
実験手法SOLUTION NMR
主引用文献NMR structure of biosynthetic engineered human insulin monomer B31(Lys)-B32(Arg) in water/acetonitrile solution. Comparison with the solution structure of native human insulin monomer
Biopolymers, 89, 2008
2TCI
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BU of 2tci by Molmil
X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL
分子名称: THIOCYANATE INSULIN, THIOCYANATE ION, ZINC ION
著者Whittingham, J.L, Dodson, E.J, Moody, P.C.E, Dodson, G.G.
登録日1995-09-13
公開日1996-01-29
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents, thiocyanate, methylparaben, and phenol.
Biochemistry, 34, 1995
4UNE
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BU of 4une by Molmil
Human insulin B26Phe mutant crystal structure
分子名称: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION
著者Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M.
登録日2014-05-28
公開日2014-10-15
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex
Acta Crystallogr.,Sect.D, 70, 2014
3MTH
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BU of 3mth by Molmil
X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL
分子名称: 4-HYDROXY-BENZOIC ACID METHYL ESTER, CHLORIDE ION, METHYLPARABEN INSULIN, ...
著者Whittingham, J.L, Dodson, E.J, Moody, P.C.E, Dodson, G.G.
登録日1995-09-13
公開日1996-01-29
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents, thiocyanate, methylparaben, and phenol.
Biochemistry, 34, 1995
4UNG
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BU of 4ung by Molmil
Human insulin B26Asn mutant crystal structure
分子名称: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION
著者Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M.
登録日2014-05-28
公開日2014-10-15
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex
Acta Crystallogr.,Sect.D, 70, 2014
4UNH
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BU of 4unh by Molmil
Human insulin B26Gly mutant crystal structure
分子名称: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION
著者Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M.
登録日2014-05-28
公開日2014-10-15
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex
Acta Crystallogr.,Sect.D, 70, 2014
5WDM
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BU of 5wdm by Molmil
An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein
分子名称: Single-chain insulin analog
著者Yee, V.C, Aldabbagh, K, Peng, Y.
登録日2017-07-05
公開日2017-11-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.803 Å)
主引用文献An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein.
J. Biol. Chem., 293, 2018
5VIZ
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BU of 5viz by Molmil
X-Ray structure of Insulin Glargine
分子名称: Insulin, chain alpha, chain beta
著者Reyes-Grajeda, J.P, Romero, A.
登録日2017-04-17
公開日2017-10-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献X-Ray structure of Insulin Glargine
To Be Published
5WBT
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Solution Structure and Dynamics of an Ultra-Stable Single-Chain Insulin Analog STUDIES OF AN ENGINEERED MONOMER AND IMPLICATIONS FOR RECEPTOR BINDING
分子名称: Insulin
著者Glidden, M.D, Yang, Y, Wickramasinghe, N.P, Weiss, M.A.
登録日2017-06-29
公開日2017-11-15
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding.
J. Biol. Chem., 293, 2018

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