7SJ4
 
 | | Human Trio residues 1284-1959 in complex with Rac1 | | 分子名称: | Ras-related C3 botulinum toxin substrate 1, Triple functional domain protein | | 著者 | Chen, C.-L, Ravala, S.K, Bandekar, S.J, Cash, J, Tesmer, J.J.G. | | 登録日 | 2021-10-15 | | 公開日 | 2022-07-06 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | | 主引用文献 | Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1.
J.Biol.Chem., 298, 2022
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8IAH
 | | Structure of mammalian spectrin-actin junctional complex of membrane skeleton, State I, Global map | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | | 著者 | Li, N, Chen, S, Gao, N. | | 登録日 | 2023-02-08 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural basis of membrane skeleton organization in red blood cells.
Cell, 186, 2023
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5JMQ
 | | Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 with CP3 | | 分子名称: | 1,2-ETHANEDIOL, 9-[(5E)-7-carbamimidamido-5,6,7-trideoxy-beta-D-ribo-hept-5-enofuranosyl]-9H-purin-6-amine, CALCIUM ION, ... | | 著者 | Cura, V, Troffer-Charlier, N, Marechal, N, Bonnefond, L, Cavarelli, J. | | 登録日 | 2016-04-29 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.795 Å) | | 主引用文献 | Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.
Febs J., 284, 2017
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8JHK
 | | Cryo-EM structure of the DOCK5/ELMO1 complex, focused on one protomer | | 分子名称: | Dedicator of cytokinesis protein 5, Engulfment and cell motility protein 1 | | 著者 | Kukimoto-Niino, M, Katsura, K, Ishizuka-Katsura, Y, Mishima-Tsumagari, C, Yonemochi, M, Inoue, M, Nakagawa, R, Kaushik, R, Zhang, K.Y.J, Shirouzu, M. | | 登録日 | 2023-05-23 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (4.76 Å) | | 主引用文献 | RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state.
J.Biol.Chem., 300, 2024
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6UY7
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6UY9
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6UY8
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7CSP
 | | Structure of Ephexin4 IDPSH | | 分子名称: | Rho guanine nucleotide exchange factor 16 | | 著者 | Zhang, M, Lin, L, Wang, C, Zhu, J. | | 登録日 | 2020-08-15 | | 公開日 | 2021-02-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Double inhibition and activation mechanisms of Ephexin family RhoGEFs.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7CSR
 | | Structure of Ephexin4 R676L | | 分子名称: | Rho guanine nucleotide exchange factor 16 | | 著者 | Zhang, M, Lin, L, Wang, C, Zhu, J. | | 登録日 | 2020-08-17 | | 公開日 | 2021-02-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Double inhibition and activation mechanisms of Ephexin family RhoGEFs.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7CSO
 | | Structure of Ephexin4 DH-PH-SH3 | | 分子名称: | Rho guanine nucleotide exchange factor 16, SULFATE ION | | 著者 | Zhang, M, Lin, L, Wang, C, Zhu, J. | | 登録日 | 2020-08-15 | | 公開日 | 2021-02-24 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Double inhibition and activation mechanisms of Ephexin family RhoGEFs.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7D7S
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7DPA
 | | Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex | | 分子名称: | Dedicator of cytokinesis protein 5, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1 | | 著者 | Kukimoto-Niino, M, Katsura, K, Kaushik, R, Ehara, H, Yokoyama, T, Uchikubo-Kamo, T, Mishima-Tsumagari, C, Yonemochi, M, Ikeda, M, Hanada, K, Zhang, K.Y.J, Shirouzu, M. | | 登録日 | 2020-12-18 | | 公開日 | 2021-08-04 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex.
Sci Adv, 7, 2021
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7TPB
 | | p120RasGAP SH3 domain in complex with DLC1 RhoGAP domain | | 分子名称: | Ras GTPase-activating protein 1, Rho GTPase-activating protein 7 | | 著者 | Stiegler, A.L, Boggon, T.J, Chau, J.E, Vish, K.J. | | 登録日 | 2022-01-25 | | 公開日 | 2022-08-03 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP.
Nat Commun, 13, 2022
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7UD6
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3REB
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3NMZ
 | | Crystal structure of APC complexed with Asef | | 分子名称: | APC variant protein, Rho guanine nucleotide exchange factor 4 | | 著者 | Zhang, Z, Chen, L, Gao, L, Lin, K, Wu, G. | | 登録日 | 2010-06-23 | | 公開日 | 2011-07-06 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | | 主引用文献 | Structural basis for the recognition of Asef by adenomatous polyposis coli.
Cell Res., 22, 2012
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3JV3
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5YPR
 | | Crystal Structure of PSD-95 SH3-GK domain in complex with a synthesized inhibitor | | 分子名称: | Disks large homolog 4, Synthesized GK inhibitor | | 著者 | Zhu, J, Zhou, Q, Shang, Y, Weng, Z, Zhu, R, Zhang, M. | | 登録日 | 2017-11-02 | | 公開日 | 2018-03-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.349 Å) | | 主引用文献 | Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs.
Cell Rep, 21, 2017
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6B25
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3EHQ
 | | Crystal Structure of Human Osteoclast Stimulating Factor | | 分子名称: | 1,2-ETHANEDIOL, Osteoclast-stimulating factor 1 | | 著者 | Tong, S, Zhou, H, Gao, Y, Zhu, Z, Zhang, X, Teng, M, Niu, L. | | 登録日 | 2008-09-14 | | 公開日 | 2009-08-04 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Crystal structure of human osteoclast stimulating factor
Proteins, 75, 2009
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2KBT
 | | Attachment of an NMR-invisible solubility enhancement tag (INSET) using a sortase-mediated protein ligation method | | 分子名称: | Proto-oncogene vav,Immunoglobulin G-binding protein G | | 著者 | Kumeta, H, Kobashigawa, Y, Ogura, K, Inagaki, F. | | 登録日 | 2008-12-07 | | 公開日 | 2009-02-03 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Attachment of an NMR-invisible solubility enhancement tag using a sortase-mediated protein ligation method
J.Biomol.Nmr, 43, 2009
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8WEJ
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3EHR
 | | Crystal Structure of Human Osteoclast Stimulating Factor | | 分子名称: | Osteoclast-stimulating factor 1 | | 著者 | Tong, S, Zhou, H, Gao, Y, Zhu, Z, Zhang, X, Teng, M, Niu, L. | | 登録日 | 2008-09-14 | | 公開日 | 2009-08-04 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal structure of human osteoclast stimulating factor
Proteins, 75, 2009
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2L3S
 | | Structure of the autoinhibited Crk | | 分子名称: | Autoinhibited Crk protein | | 著者 | Kalodimos, C.G, Sarkar, P, Saleh, T, Tzeng, S.R, Birge, R. | | 登録日 | 2010-09-21 | | 公開日 | 2010-12-08 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for regulation of the Crk signaling protein by a proline switch.
Nat.Chem.Biol., 7, 2011
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8ZJJ
 | | Structure of DOCK5/ELMO1/Rac1 core (RhoG/DOCK5/ELMO1/Rac1 dataset, class 2) | | 分子名称: | Dedicator of cytokinesis protein 5, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1 | | 著者 | Kukimoto-Niino, M, Katsura, K, Ishizuka-Katsura, Y, Mishima-Tsumagari, C, Yonemochi, M, Inoue, M, Nakagawa, R, Kaushik, R, Zhang, K.Y.J, Shirouzu, M. | | 登録日 | 2024-05-15 | | 公開日 | 2024-06-26 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (4.23 Å) | | 主引用文献 | RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state.
J.Biol.Chem., 300, 2024
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