6ORD
 
 | | Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to cognate 70S A site | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Nguyen, H.A, Sunita, S, Dunham, C.M. | | 登録日 | 2019-04-30 | | 公開日 | 2020-06-24 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Disruption of evolutionarily correlated tRNA elements impairs accurate decoding.
Proc.Natl.Acad.Sci.USA, 117, 2020
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4WZD
 | | Complex of 70S ribosome with cognate tRNA-Tyr in the P-site | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Rozov, A, Demeshkina, N, Yusupov, M, Yusupova, G. | | 登録日 | 2014-11-19 | | 公開日 | 2015-06-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structural insights into the translational infidelity mechanism.
Nat Commun, 6, 2015
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4V5Q
 | | The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a near- cognate codon on the 70S ribosome | | 分子名称: | 16S RRNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | | 著者 | Schmeing, T.M, Voorhees, R.M, Ramakrishnan, V. | | 登録日 | 2010-12-07 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | How Mutations in tRNA Distant from the Anticodon Affect the Fidelity of Decoding.
Nat.Struct.Mol.Biol., 18, 2011
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4YZV
 | | Precleavage 70S structure of the P. vulgaris HigB deltaH92 toxin bound to the ACA codon | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Schureck, M.A, Dunkle, J.A, Maehigashi, T, Dunham, C.M. | | 登録日 | 2015-03-25 | | 公開日 | 2015-10-21 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Defining the mRNA recognition signature of a bacterial toxin protein.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4V87
 | | Crystal structure analysis of ribosomal decoding. | | 分子名称: | 16S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ... | | 著者 | Demeshkina, N, Jenner, L, Yusupov, M, Yusupova, G. | | 登録日 | 2011-09-20 | | 公開日 | 2014-07-09 | | 最終更新日 | 2014-12-10 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | A new understanding of the decoding principle on the ribosome.
Nature, 484, 2012
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4ZER
 | | Crystal structure of the Onc112 antimicrobial peptide bound to the Thermus thermophilus 70S ribosome | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16s ribosomal RNA, 23s ribosomal RNA, ... | | 著者 | Seefeldt, A.C, Nguyen, F, Antunes, S, Perebaskine, N, Graf, M, Arenz, S, Inampudi, K.K, Douat, C, Guichard, G, Wilson, D.N, Innis, C.A. | | 登録日 | 2015-04-20 | | 公開日 | 2015-05-20 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex.
Nat.Struct.Mol.Biol., 22, 2015
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7AZS
 | | 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569 | | 分子名称: | (2R,3S,4R,5R,7S,9S,10S,11R,12S,13R)-12-(((2R,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-2-((S)-1-(((2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)propan-2-yl)-10-(((2S,3R,6R,E)-3-hydroxy-4-(methoxyimino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,5,7,9,11,13-hexamethyl-7-(((2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)carbamoyl)oxy)-6,14-dioxooxacyclotetradecan-4-yl 3-methylbutanoate, 16S rRNA, 23S rRNA, ... | | 著者 | Jenner, L.B, Yusupov, M, Yusupova, G, Rak, A. | | 登録日 | 2020-11-17 | | 公開日 | 2022-06-08 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
Cell, 186, 2023
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5DOX
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with Hygromycin-A at 3.1A resolution | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Polikanov, Y.S, Starosta, A.L, Juette, M.F, Altman, R.B, Terry, D.S, Lu, W, Burnett, B.J, Dinos, G, Reynolds, K, Blanchard, S.C, Steitz, T.A, Wilson, D.N. | | 登録日 | 2015-09-11 | | 公開日 | 2015-12-30 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol.Cell, 58, 2015
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5EL6
 | | Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Rozov, A, Demeshkina, N, Khusainov, I, Yusupov, M, Yusupova, G. | | 登録日 | 2015-11-04 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code.
Nat Commun, 7, 2016
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6NTA
 | | Modified ASL proline bound to Thermus thermophilus 70S (cognate) | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Hoffer, E.D, Maehigashi, T, Subaramanian, S, Hong, S, Dunham, C.M. | | 登録日 | 2019-01-28 | | 公開日 | 2020-10-14 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon-anticodon pairing.
Elife, 9, 2020
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6OTR
 | | Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (AAU) | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Pavelich, I.P, Hoffer, E.D, Maehigashi, T, Dunham, C.M. | | 登録日 | 2019-05-03 | | 公開日 | 2019-08-21 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | | 主引用文献 | Monomeric YoeB toxin retains RNase activity but adopts an obligate dimeric form for thermal stability.
Nucleic Acids Res., 47, 2019
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5IB8
 | | Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNALys with U-G mismatch in the A-site | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Rozov, A, Demeshkina, N, Yusupov, M, Yusupova, G. | | 登録日 | 2016-02-22 | | 公開日 | 2016-05-25 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.13 Å) | | 主引用文献 | The ribosome prohibits the GU wobble geometry at the first position of the codon-anticodon helix.
Nucleic Acids Res., 44, 2016
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6CZR
 | | The structure of amicetin bound to the 70S ribosome | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | | 著者 | Eiler, D.R, Steitz, T.A, Looper, R.E, Serrano, C.M, Kannareddy, H.R, Koch, M.R, Barrows, L.R, Testa, C.A, Sebahar, P.R. | | 登録日 | 2018-04-09 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3.14 Å) | | 主引用文献 | Unifying the Aminohexopyranose- and Peptidyl-Nucleoside Antibiotics: Implications for Antibiotic Design
Angew.Chem.Int.Ed.Engl., 132, 2020
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4LT8
 | | Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-G on the Ribosome | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Maehigashi, T, Dunkle, J.A, Dunham, C.M. | | 登録日 | 2013-07-23 | | 公開日 | 2014-08-06 | | 最終更新日 | 2014-12-10 | | 実験手法 | X-RAY DIFFRACTION (3.14000177 Å) | | 主引用文献 | Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4WQR
 | | Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the first position in the A-site. | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Rozov, A, Demeshkina, N, Yusupov, M, Yusupova, G. | | 登録日 | 2014-10-22 | | 公開日 | 2015-06-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Structural insights into the translational infidelity mechanism.
Nat Commun, 6, 2015
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5EL4
 | | Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Rozov, A, Demeshkina, N, Khusainov, I, Yusupov, M, Yusupova, G. | | 登録日 | 2015-11-04 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code.
Nat Commun, 7, 2016
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5EL7
 | | Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position and antibiotic paromomycin | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Rozov, A, Demeshkina, N, Khusainov, I, Yusupov, M, Yusupova, G. | | 登録日 | 2015-11-04 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code.
Nat Commun, 7, 2016
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5EL5
 | | Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Rozov, A, Demeshkina, N, Khusainov, I, Yusupov, M, Yusupova, G. | | 登録日 | 2015-11-04 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code.
Nat Commun, 7, 2016
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5NDJ
 | | Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking) | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Prokhorova, I, Djumagulov, M, Urzhumtsev, A, Yusupov, M, Yusupova, G. | | 登録日 | 2017-03-08 | | 公開日 | 2018-05-02 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Aminoglycoside interactions and impacts on the eukaryotic ribosome.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6GSL
 | | Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAArg in the A-site | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Rozov, A, Yusupov, M, Yusupova, G. | | 登録日 | 2018-06-14 | | 公開日 | 2018-07-04 | | 最終更新日 | 2018-09-05 | | 実験手法 | X-RAY DIFFRACTION (3.16 Å) | | 主引用文献 | Tautomeric G•U pairs within the molecular ribosomal grip and fidelity of decoding in bacteria.
Nucleic Acids Res., 46, 2018
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6BZ6
 | | Thermus thermophilus 70S complex containing 16S G347U ram mutation and empty A site | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Hoffer, E.D, Maehigashi, T, Fagan, C.E, Dunham, C.M. | | 登録日 | 2017-12-22 | | 公開日 | 2018-11-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | | 主引用文献 | Ribosomal ambiguity (ram) mutations promote the open (off) to closed (on) transition and thereby increase miscoding.
Nucleic Acids Res., 47, 2019
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4V8A
 | | The structure of thermorubin in complex with the 70S ribosome from Thermus thermophilus. | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Bulkley, D, Johnson, F.A, Steitz, T.A. | | 登録日 | 2011-12-05 | | 公開日 | 2014-07-09 | | 最終更新日 | 2014-12-10 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge b2a of the ribosome.
J.Mol.Biol., 416, 2012
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4V95
 | | Crystal structure of YAEJ bound to the 70S ribosome | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | | 著者 | Gagnon, M.G, Seetharaman, S.V, Bulkley, D.P, Steitz, T.A. | | 登録日 | 2012-01-27 | | 公開日 | 2014-07-09 | | 最終更新日 | 2018-07-11 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome.
Science, 335, 2012
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6OF6
 | | Crystal structure of tRNA^ Ala(GGC) bound to cognate 70S A-site | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Nguyen, H.A, Sunita, S, Dunham, C.M. | | 登録日 | 2019-03-28 | | 公開日 | 2020-06-24 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Disruption of evolutionarily correlated tRNA elements impairs accurate decoding.
Proc.Natl.Acad.Sci.USA, 117, 2020
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4WU1
 | | Complex of 70S ribosome with tRNA-Tyr and mRNA with G-U mismatch in the second position in the P-site | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Rozov, A, Demeshkina, N, Yusupov, M, Yusupova, G. | | 登録日 | 2014-10-30 | | 公開日 | 2015-06-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural insights into the translational infidelity mechanism.
Nat Commun, 6, 2015
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