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PDB: 296 件
4I6L
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BU of 4i6l by Molmil
Crystal structure of OTUB1 in complex with ubiquitin variant
分子名称: Ubiquitin, Ubiquitin thioesterase OTUB1
著者Juang, Y.C, Sicheri, F.
登録日2012-11-29
公開日2013-01-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.488 Å)
主引用文献A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
7R70
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BU of 7r70 by Molmil
Crystal Structure of the UbArk2C fusion protein
分子名称: GLYCEROL, Ubiquitin,E3 ubiquitin-protein ligase RNF165, ZINC ION
著者Paluda, A, Middleton, A.J, Mace, P.D, Day, C.L.
登録日2021-06-24
公開日2022-03-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.499 Å)
主引用文献Ubiquitin and a charged loop regulate the ubiquitin E3 ligase activity of Ark2C.
Nat Commun, 13, 2022
8SSI
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BU of 8ssi by Molmil
Structure of Burkholderia pseudomallei deubiquitinase TssM in complex with ubiquitin
分子名称: Deubiquitinase TssM, GLYCEROL, Ubiquitin, ...
著者Szczesna, M, Pruneda, J.N, Thurston, T.L.M.
登録日2023-05-08
公開日2024-06-05
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Burkholderia esterase TssM counters RNF213-mediated bacterial ubiquitylation
To Be Published
3WXE
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BU of 3wxe by Molmil
Crystal structure of CYLD USP domain (C596S) in complex with Met1-linked diubiquitin
分子名称: Ubiquitin, Uncharacterized protein
著者Sato, Y, Fukai, S.
登録日2014-07-30
公開日2015-02-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity.
Nat.Struct.Mol.Biol., 22, 2015
3RUL
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BU of 3rul by Molmil
New strategy to analyze structures of glycopeptide-target complexes
分子名称: 10-METHYLUNDECANOIC ACID, 2-amino-2-deoxy-beta-D-glucopyranuronic acid, CHLORIDE ION, ...
著者Economou, N.J, Nahoum, V, Weeks, S.D, Grasty, K.C, Loll, P.J.
登録日2011-05-05
公開日2012-06-06
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A carrier protein strategy yields the structure of dalbavancin.
J.Am.Chem.Soc., 134, 2012
3PT2
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BU of 3pt2 by Molmil
Structure of a viral OTU domain protease bound to Ubiquitin
分子名称: 1.7.6 3-bromanylpropan-1-amine, ACETATE ION, RNA polymerase, ...
著者James, T.W, Bacik, J.P, Frias-Staheli, N, Garcia-Sastre, A, Mark, B.L.
登録日2010-12-02
公開日2011-01-19
最終更新日2023-05-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease.
Proc.Natl.Acad.Sci.USA, 108, 2011
2GMI
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BU of 2gmi by Molmil
Mms2/Ubc13~Ubiquitin
分子名称: Ubiquitin, Ubiquitin-conjugating enzyme E2 13, Ubiquitin-conjugating enzyme variant MMS2
著者Wolberger, C, Eddins, M.J, Carlile, C.M, Gomez, K.G, Pickart, C.M.
登録日2006-04-06
公開日2006-09-19
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation.
Nat.Struct.Mol.Biol., 13, 2006
8ST9
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BU of 8st9 by Molmil
Structure of E3 ligase NleL bound to ubiquitin
分子名称: E3 ubiquitin-protein ligase SopA, Ubiquitin, prop-2-en-1-amine
著者Franklin, T.G, Pruneda, J.N.
登録日2023-05-09
公開日2023-07-12
最終更新日2024-01-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Bacterial ligases reveal fundamental principles of polyubiquitin specificity.
Mol.Cell, 83, 2023
7EAL
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BU of 7eal by Molmil
The structure of the A20-Binding Inhibitor of NF-kB 1 in complex with di-ubiquitin
分子名称: GLYCEROL, TNFAIP3-interacting protein 1, ubiquitin
著者Lo, Y.C, Lin, S.C.
登録日2021-03-07
公開日2021-07-21
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural and Biochemical Basis for Higher-Order Assembly between A20-Binding Inhibitor of NF-kappa B 1 (ABIN1) and M1-Linked Ubiquitins.
J.Mol.Biol., 433, 2021
7M4N
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BU of 7m4n by Molmil
Crystal structure of RBR E3 ligase RNF216 in complex with K63-linked di-ubiquitin
分子名称: E3 ubiquitin-protein ligase RNF216, GLYCEROL, SULFATE ION, ...
著者Cotton, T.R, Lechtenberg, B.C.
登録日2021-03-21
公開日2022-01-05
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216.
Mol.Cell, 82, 2022
7ZJ3
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BU of 7zj3 by Molmil
Structure of TRIM2 RING domain in complex with UBE2D1~Ub conjugate
分子名称: Polyubiquitin-C, Tripartite motif-containing protein 2, Ubiquitin-conjugating enzyme E2 D1, ...
著者Esposito, D, Garza-Garcia, A, Dudley-Fraser, J, Rittinger, K.
登録日2022-04-08
公開日2022-11-30
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
Nat Commun, 13, 2022
7BBF
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BU of 7bbf by Molmil
Crystal structure of ubiquitin charged Ube2N (Ube2N~Ub) in complex with Ube2V2
分子名称: Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2
著者Kiss, L, Neuhaus, D, James, L.C.
登録日2020-12-17
公開日2021-01-27
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination.
Nat Commun, 12, 2021
6K2U
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BU of 6k2u by Molmil
Crystal structure of Thr66 ADP-ribosylated ubiquitin
分子名称: ADENOSINE-5-DIPHOSPHORIBOSE, MAGNESIUM ION, Polyubiquitin-C, ...
著者Wang, X, Zhou, Y, Zhu, Y.
登録日2019-05-15
公開日2020-03-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.554 Å)
主引用文献Threonine ADP-Ribosylation of Ubiquitin by a Bacterial Effector Family Blocks Host Ubiquitination.
Mol.Cell, 78, 2020
6T7F
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BU of 6t7f by Molmil
RCR E3 ligase E2-Ubiquitin transthiolation intermediate
分子名称: 3,3-bis(sulfanyl)-~{N}-(1~{H}-1,2,3-triazol-4-ylmethyl)propanamide, E3 ubiquitin-protein ligase MYCBP2, Polyubiquitin-C, ...
著者Mabbitt, P.D, Virdee, S.
登録日2019-10-21
公開日2020-08-05
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity.
Nat.Chem.Biol., 16, 2020
5H07
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BU of 5h07 by Molmil
TNIP2-Ub complex, C2 form
分子名称: Polyubiquitin-C, TNFAIP3-interacting protein 2
著者Lo, Y.C, Lin, S.C.
登録日2016-10-04
公開日2017-03-08
実験手法X-RAY DIFFRACTION (2.586 Å)
主引用文献Structural Insights into Linear Tri-ubiquitin Recognition by A20-Binding Inhibitor of NF-kappa B, ABIN-2
Structure, 25, 2017
3I3T
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BU of 3i3t by Molmil
Crystal structure of covalent ubiquitin-USP21 complex
分子名称: ETHANAMINE, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 21, ...
著者Neculai, D, Avvakumov, G.V, Walker, J.R, Xue, S, Butler-Cole, C, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2009-06-30
公開日2009-07-21
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
7YUI
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BU of 7yui by Molmil
Crystal structure of HOIL-1L(195-423) in complex with the linear tetra-ubiquitin
分子名称: Polyubiquitin-C, RanBP-type and C3HC4-type zinc finger-containing protein 1, ZINC ION
著者Xiao, L, Pan, L.
登録日2022-08-17
公開日2023-08-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.599 Å)
主引用文献Mechanistic insights into the enzymatic activity of E3 ligase HOIL-1L and its regulation by the linear ubiquitin chain binding.
Sci Adv, 9, 2023
3N3K
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BU of 3n3k by Molmil
The catalytic domain of USP8 in complex with a USP8 specific inhibitor
分子名称: Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 8, ZINC ION
著者Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Allali-Hassani, A, Lam, R, Ernst, A, Sidhu, S, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium, Structural Genomics Consortium (SGC)
登録日2010-05-20
公開日2010-06-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
3DVG
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BU of 3dvg by Molmil
Crystal structure of K63-specific fab Apu.3A8 bound to K63-linked di-ubiquitin
分子名称: Human IgG1 fab fragment heavy chain, Human IgG1 fab fragment light chain, Ubiquitin, ...
著者Hymowitz, S.G.
登録日2008-07-18
公開日2008-09-30
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies.
Cell(Cambridge,Mass.), 134, 2008
2OJR
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BU of 2ojr by Molmil
Structure of ubiquitin solved by SAD using the Lanthanide-Binding Tag
分子名称: TERBIUM(III) ION, Ubiquitin
著者Silvaggi, N.R, Allen, K.N.
登録日2007-01-13
公開日2007-06-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Double-Lanthanide-Binding Tags for Macromolecular Crystallographic Structure Determination.
J.Am.Chem.Soc., 129, 2007
3LDZ
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BU of 3ldz by Molmil
Crystal structure of human STAM1 VHS domain in complex with ubiquitin
分子名称: Signal transducing adapter molecule 1, Ubiquitin
著者Ren, X, Hurley, J.H.
登録日2010-01-13
公開日2010-03-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo.
Embo J., 29, 2010
4MDK
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BU of 4mdk by Molmil
Cdc34-ubiquitin-CC0651 complex
分子名称: 4,5-dideoxy-5-(3',5'-dichlorobiphenyl-4-yl)-4-[(methoxyacetyl)amino]-L-arabinonic acid, Ubiquitin, Ubiquitin-conjugating enzyme E2 R1
著者Ceccarelli, D.F, Orlicky, S, Tyers, M, Sicheri, F.
登録日2013-08-22
公開日2013-12-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.6095 Å)
主引用文献E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.
Nat.Chem.Biol., 10, 2014
6WTG
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BU of 6wtg by Molmil
SdeA DUB Domain in complex with Ubiquitin
分子名称: Ubiquitin, Ubiquitinating/deubiquitinating enzyme SdeA
著者Kenny, S, Sheedlo, M, Das, C.
登録日2020-05-02
公開日2021-03-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Insights into Ubiquitin Product Release in Hydrolysis Catalyzed by the Bacterial Deubiquitinase SdeA.
Biochemistry, 60, 2021
6Z7V
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BU of 6z7v by Molmil
Crystal structure of Mindy2 (C266A) in complex with Lys48 linked di-ubiquitin (K48-Ub2)
分子名称: POTASSIUM ION, Polyubiquitin-C, TETRAETHYLENE GLYCOL, ...
著者Abdul Rehman, S.A, Lange, S.M, Kulathu, Y.
登録日2020-06-01
公開日2021-06-09
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2.
Mol.Cell, 81, 2021
5B83
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BU of 5b83 by Molmil
Crystal structure of Optineurin UBAN in complex with linear ubiquitin
分子名称: Optineurin, tetra ubiquitin
著者Ishii, R, Nureki, O.
登録日2016-06-12
公開日2016-09-07
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.694 Å)
主引用文献Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis
Nat Commun, 7, 2016

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