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PDB: 1180 件
5U1R
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BU of 5u1r by Molmil
Structure of human MR1-diclofenac in complex with human MAIT A-F7 TCR
分子名称: 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, ACETATE ION, Beta-2-microglobulin, ...
著者Keller, A.N, Rossjohn, J.
登録日2016-11-28
公開日2017-03-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.
Nat. Immunol., 18, 2017
3KPS
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BU of 3kps by Molmil
Crystal Structure of the LC13 TCR in complex with HLA B*4405 bound to EEYLQAFTY a self peptide from the ABCD3 protein
分子名称: Beta-2-microglobulin, EEYLQAFTY, self peptide from the ATP binding cassette protein ABCD3, ...
著者Macdonald, W.A, Chen, Z, Gras, S, Archbold, J.K, Tynan, F.E, Clements, C.S, Bharadwaj, M, Kjer-Nielsen, L, Saunders, P.M, Wilce, M.C, Crawford, F, Stadinsky, B, Jackson, D, Brooks, A.G, Purcell, A.W, Kappler, J.W, Burrows, S.R, Rossjohn, J, McCluskey, J.
登録日2009-11-16
公開日2009-12-22
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献T cell allorecognition via molecular mimicry.
Immunity, 31, 2009
3MZT
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BU of 3mzt by Molmil
Protein-induced photophysical changes to the amyloid indicator dye, thioflavin T
分子名称: 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium, Beta-2-microglobulin, COPPER (II) ION
著者Wolfe, L.S, Calabrese, M.F, Nath, A, Blaho, D.V, Miranker, A.D, Xiong, Y.
登録日2010-05-13
公開日2010-09-08
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Protein-induced photophysical changes to the amyloid indicator dye thioflavin T.
Proc.Natl.Acad.Sci.USA, 107, 2010
5YXU
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BU of 5yxu by Molmil
an affinity enhanced T cell receptor in complex with HLA-A0201 restricted HCV NS3 peptide KLVALGINAV
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ...
著者Yi, L.
登録日2017-12-07
公開日2018-12-12
最終更新日2019-02-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献an affinity enhanced T cell receptor in complex with HLA-A0201 restricted HCV NS3 peptide KLVALGINAV
To Be Published
1QQD
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BU of 1qqd by Molmil
CRYSTAL STRUCTURE OF HLA-CW4, A LIGAND FOR THE KIR2D NATURAL KILLER CELL INHIBITORY RECEPTOR
分子名称: BETA-2 MICROGLOBULIN, HISTOCOMPATIBILITY LEUKOCYTE ANTIGEN (HLA)-CW4 (HEAVY CHAIN), HLA-CW4 SPECIFIC PEPTIDE
著者Fan, Q.R, Wiley, D.C.
登録日1999-06-03
公開日1999-12-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor
J.Exp.Med., 190, 1999
4NO0
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BU of 4no0 by Molmil
Crystal structure of non-phosphorylated form of RQA_V phosphopeptide bound to HLA-A2 in complex with LILRB1
分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, HLA class I histocompatibility antigen, ...
著者Mohammed, F, Stones, D.H, Willcox, B.E.
登録日2013-11-19
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The antigenic identity of human class I MHC phosphopeptides is critically dependent upon phosphorylation status.
Oncotarget, 8, 2017
2F54
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BU of 2f54 by Molmil
Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity
分子名称: Beta-2-microglobulin, Cancer/testis antigen 1B, HLA class I histocompatibility antigen, ...
著者Rizkallah, P.J, Jakobsen, B.K, Dunn, S.M, Sami, M.
登録日2005-11-25
公開日2006-04-25
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
Protein Sci., 15, 2006
3TM6
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BU of 3tm6 by Molmil
Crystal structure of the beta-2 microglobulin DIMC50 disulphide-linked homodimer mutant
分子名称: Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, PHOSPHATE ION
著者Colombo, M, Ricagno, S, Bolognesi, M.
登録日2011-08-31
公開日2012-09-05
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献A recurrent D-strand association interface is observed in beta-2 microglobulin oligomers.
Febs J., 279, 2012
7EDO
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BU of 7edo by Molmil
First insight into marsupial MHC I peptide presentation: immune features of lower mammals paralleled with bats
分子名称: Beta-2-microglobulin, CYS-ASN-VAL-THR-LEU-ASN-TYR-PRO, MHC class I antigen
著者Wang, P.Y, Yue, C, Lu, D, Liu, K.F, Liu, S, Yao, S.J, Chai, Y, Qi, J.X, Lou, Y.L, Sun, Z.Y, Gao, G.F, Liu, W.J.
登録日2021-03-16
公開日2021-08-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Peptide Presentations of Marsupial MHC Class I Visualize Immune Features of Lower Mammals Paralleled with Bats.
J Immunol., 207, 2021
3H9S
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BU of 3h9s by Molmil
The complex between TCR A6 and human Class I MHC HLA-A2 with the bound Tel1p peptide
分子名称: A6 TCR alpha chain, Beta-2-microglobulin, GLYCEROL, ...
著者Borbulevych, O.Y, Baker, B.M.
登録日2009-04-30
公開日2010-01-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility.
Immunity, 31, 2009
2F74
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BU of 2f74 by Molmil
Murine MHC class I H-2Db in complex with human b2-microglobulin and LCMV-derived immunodminant peptide gp33
分子名称: Beta-2-microglobulin, H-2 class I histocompatibility antigen, D-B alpha chain, ...
著者Achour, A, Michaelsson, J, Harris, R.A, Ljunggren, H.G, Karre, K, Schneider, G, Sandalova, T.
登録日2005-11-30
公開日2006-02-14
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Basis of the Differential Stability and Receptor Specificity of H-2D(b) in Complex with Murine versus Human beta(2)-Microglobulin.
J.Mol.Biol., 356, 2006
8EN8
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BU of 8en8 by Molmil
Cross-reactive 3180 TCR recognition of HLA-B*35:01-NP4 epitope from 1972 influenza strain
分子名称: 3180 TCR alpha chain, 3180 TCR beta chain, Beta-2-microglobulin, ...
著者Littler, D.R, Rossjohn, J.
登録日2022-09-29
公開日2024-03-27
実験手法X-RAY DIFFRACTION (2.700012 Å)
主引用文献Molecular determinants of cross-strain influenza A virus recognition by T-cell receptors
To Be Published
4ONO
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BU of 4ono by Molmil
CD1c in complex with PM (phosphomycoketide)
分子名称: (4R,8S,16S,20R)-4,8,12,16,20-pentamethylheptacosyl dihydrogen phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin/T-cell surface glycoprotein CD1c/T-cell surface glycoprotein CD1b chimeric protein, ...
著者Roy, S, Adams, E.J.
登録日2014-01-28
公開日2014-10-08
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.705 Å)
主引用文献Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by alpha beta T cells.
Proc.Natl.Acad.Sci.USA, 111, 2014
5MEP
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BU of 5mep by Molmil
Human Leukocyte Antigen A02 presenting ILGKFLHWL
分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, HLA class I histocompatibility antigen, ...
著者Rizkallah, P.J, Cole, D.K, Lloyd, A, Crowther, M, Sewell, A.K.
登録日2016-11-16
公開日2016-12-07
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.
J. Biol. Chem., 292, 2017
3UTS
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BU of 3uts by Molmil
1E6-A*0201-ALWGPDPAAA Complex, Monoclinic
分子名称: 1E6 TCR Alpha Chain, 1E6 TCR Beta Chain, Beta-2-microglobulin, ...
著者Rizkallah, P.J, Cole, D.K, Sewell, A.K, Bulek, A.M.
登録日2011-11-26
公開日2012-01-25
最終更新日2012-03-07
実験手法X-RAY DIFFRACTION (2.712 Å)
主引用文献Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Nat.Immunol., 13, 2012
8ESH
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BU of 8esh by Molmil
Structure of chimeric HLA-A*02:01 bound to CMV peptide
分子名称: Beta-2-microglobulin, CMV peptide, HLA-A*02:01
著者Florio, T.J, Ani, O, Young, M.C, Mallik, L, Sgourakis, N.G.
登録日2022-10-14
公開日2023-01-25
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules.
Front Immunol, 14, 2023
6GGM
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BU of 6ggm by Molmil
HLA-E*01:03 in complex with the Mtb44 peptide variant: Mtb44*P2-Phe.
分子名称: Beta-2-microglobulin, MHC class I antigen, Mtb44*P2-Phe peptide variant (ARG-PHE-PRO-ALA-LYS-ALA-PRO-LEU-LEU), ...
著者Walters, L.C, Gillespie, G.M, McMichael, A.J, Rozbesky, D, Jones, E.Y, Harlos, K.
登録日2018-05-03
公開日2018-08-08
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.734 Å)
主引用文献Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.
Nat Commun, 9, 2018
4FTV
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BU of 4ftv by Molmil
The complex between the high affinity version of A6 TCR (A6c134) and human Class I MHC HLA-A2 with the bound TAX nonameric peptide
分子名称: A6 alpha chain, A6 beta chain, Beta-2-microglobulin, ...
著者Borbulevych, O.Y, Baker, B.M.
登録日2012-06-28
公開日2013-07-03
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Structure of a high affinity TCR reveals native binding to MHC with enhanced peptide specificity
To be Published
4MNQ
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BU of 4mnq by Molmil
TCR-peptide specificity overrides affinity enhancing TCR-MHC interactions
分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ...
著者Rizkallah, P.J, Cole, D.K, Sewell, A.K, Jakobsen, B.K.
登録日2013-09-11
公開日2013-11-13
最終更新日2017-08-02
実験手法X-RAY DIFFRACTION (2.742 Å)
主引用文献T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.
J.Biol.Chem., 289, 2014
6D7G
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BU of 6d7g by Molmil
Structure of 5F3 TCR in complex with HLA-A2/MART-1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MART1 PEPTIDE-BETA-2-MICROGLOBULIN-HLA-A*02 CHIMERA, T-CELL RECEPTOR GAMMA VARIABLE 8,T-CELL RECEPTOR GAMMA-2 CHAIN C REGION, ...
著者Roy, S, Adams, E.J.
登録日2018-04-24
公開日2019-01-23
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Generation and molecular recognition of melanoma-associated antigen-specific human gamma delta T cells.
Sci Immunol, 3, 2018
5NMG
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BU of 5nmg by Molmil
868 TCR in complex with HLA A02 presenting SLYFNTIAVL
分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ...
著者Rizkallah, P.J, Cole, D.K, Fuller, A, Sewell, A.K.
登録日2017-04-05
公開日2017-11-15
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope.
Front Immunol, 8, 2017
6VMA
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BU of 6vma by Molmil
T4H2 T cell receptor bound to HLA-A2 presenting gp100 peptide (ITDQVPFSV)
分子名称: Beta-2-microglobulin, MHC class I antigen, A-2 alpha chain, ...
著者Smith, A.R, Baker, B.M.
登録日2020-01-27
公開日2021-01-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structurally silent peptide anchor modifications allosterically modulate T cell recognition in a receptor-dependent manner
Proc.Natl.Acad.Sci.USA, 118, 2021
5WKI
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BU of 5wki by Molmil
Crystal structure of PG90 TCR-CD1b-PG complex
分子名称: (19S,22R,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9E)-octadec-9-enoate, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Shahine, A, Gras, S, Rossjohn, J.
登録日2017-07-25
公開日2017-11-01
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献A molecular basis of human T cell receptor autoreactivity toward self-phospholipids.
Sci Immunol, 2, 2017
7JYU
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BU of 7jyu by Molmil
Crystal Structure of HLA-A*2402 in complex with IYFSPIRVTF, an 10-mer epitope from Influenza B virus
分子名称: Beta-2-microglobulin, MAGNESIUM ION, MHC class I antigen, ...
著者Nguyen, A.T, Szeto, C, Rossjohn, J, Gras, S.
登録日2020-09-01
公開日2021-04-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献CD8 + T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph.
Nat Commun, 12, 2021
6V7Z
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BU of 6v7z by Molmil
Human CD1d presenting alpha-Galactosylceramide in complex with VHH nanobody 1D22
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d, ...
著者Shahine, A, Rossjohn, J.
登録日2019-12-10
公開日2020-09-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response.
Nat Cancer, 2020

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