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PDB: 13 件
8C3N
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Stapled peptide SP30 in complex with humanised RadA mutant HumRadA22
分子名称: 4,6-diethylpyrimidin-2-amine, ADENOSINE-5'-DIPHOSPHATE, Breast cancer type 2 susceptibility protein, ...
著者Pantelejevs, T, Hyvonen, M.
登録日2022-12-27
公開日2023-03-08
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.21 Å)
主引用文献A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase.
Chem Sci, 14, 2023
8BR9
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Stapled peptide SP24 in complex with humanised RadA mutant HumRadA22
分子名称: 4,6-diethylpyrimidin-2-amine, ADENOSINE-5'-DIPHOSPHATE, Breast cancer type 2 susceptibility protein, ...
著者Pantelejevs, T, Hyvonen, M.
登録日2022-11-22
公開日2023-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase.
Chem Sci, 14, 2023
1N0W
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Crystal structure of a RAD51-BRCA2 BRC repeat complex
分子名称: 1,2-ETHANEDIOL, ARTIFICIAL GLY-SER-MSE-GLY PEPTIDE, Breast cancer type 2 susceptibility protein, ...
著者Pellegrini, L, Yu, D.S, Lo, T, Anand, S, Lee, M, Blundell, T.L, Venkitaraman, A.R.
登録日2002-10-15
公開日2002-11-27
最終更新日2020-01-22
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Insights into DNA recombination from the structure of a RAD51-BRCA2 complex
Nature, 420, 2002
6HQU
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Humanised RadA mutant HumRadA22 in complex with a recombined BRC repeat 8-2
分子名称: ADENOSINE-5'-DIPHOSPHATE, Breast cancer type 2 susceptibility, DNA repair and recombination protein RadA, ...
著者Pantelejevs, T, Lindenburg, L, Hyvonen, M, Hollfelder, F.
登録日2018-09-25
公開日2019-10-09
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats.
Proc.Natl.Acad.Sci.USA, 118, 2021
3EU7
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BU of 3eu7 by Molmil
Crystal Structure of a PALB2 / BRCA2 complex
分子名称: 19meric peptide from Breast cancer type 2 susceptibility protein, GLYCEROL, Partner and localizer of BRCA2
著者Oliver, A.W, Pearl, L.H.
登録日2008-10-09
公開日2009-07-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for recruitment of BRCA2 by PALB2
Embo Rep., 10, 2009
7LDG
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BU of 7ldg by Molmil
Crystal structure of the MEILB2-BRCA2 complex
分子名称: Breast cancer type 2 susceptibility protein, Heat shock factor 2-binding protein
著者Nandakumar, J, Pendlebury, D.F.
登録日2021-01-13
公開日2021-08-11
最終更新日2021-08-25
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites.
Nat.Struct.Mol.Biol., 28, 2021
7BDX
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BU of 7bdx by Molmil
Armadillo domain of HSF2BP in complex with BRCA2 peptide
分子名称: Breast cancer type 2 susceptibility protein, Heat shock factor 2-binding protein, MAGNESIUM ION
著者Le Du, M.H, Zinn-Justin, S, Ghouil, R, Miron, S, Legrand, P.
登録日2020-12-22
公開日2021-07-07
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination.
Nat Commun, 12, 2021
8PBC
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RAD51 filament on ssDNA bound by the BRCA2 c-terminus
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Breast cancer type 2 susceptibility protein, CALCIUM ION, ...
著者Appleby, R, Pellegrini, L.
登録日2023-06-09
公開日2023-11-15
実験手法ELECTRON MICROSCOPY (2.61 Å)
主引用文献Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2.
Nat Commun, 14, 2023
8PBD
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RAD51 filament on dsDNA bound by the BRCA2 c-terminus
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Breast cancer type 2 susceptibility protein, CALCIUM ION, ...
著者Appleby, R, Pellegrini, L.
登録日2023-06-09
公開日2023-11-15
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2.
Nat Commun, 14, 2023
8C3J
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BU of 8c3j by Molmil
Stapled peptide SP2 in complex with humanised RadA mutant HumRadA22
分子名称: 2-[(4,6-diethyl-1,3,5-triazin-2-yl)-methyl-amino]ethanoic acid, Breast cancer type 2 susceptibility protein, DNA repair and recombination protein RadA
著者Pantelejevs, T, Hyvonen, M.
登録日2022-12-26
公開日2023-11-29
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.02 Å)
主引用文献A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase.
Chem Sci, 14, 2023
6GY2
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Crystal structure of human Plk1-PBD in complex with WSSSLATPPTLSSpTVLI phosphopeptide from BRCA2
分子名称: GLYCEROL, Phosphopeptide of BRCA2, Serine/threonine-protein kinase PLK1
著者Miron, S, Ropars, V, Zinn-Justin, S.
登録日2018-06-28
公開日2019-07-10
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.
Nat Commun, 11, 2020
8R2G
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Crystal structure of a BRCA2-DMC1 complex
分子名称: Breast cancer type 2 susceptibility protein, Meiotic recombination protein DMC1/LIM15 homolog
著者Dunce, J.M, Davies, O.R.
登録日2023-11-05
公開日2023-11-22
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献Crystal structure of a BRCA2-DMC1 complex
To Be Published
8QQE
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Crystal structure of the complex between DMC1 and the PhePP domain of BRCA2
分子名称: Breast cancer type 2 susceptibility protein, CHLORIDE ION, MAGNESIUM ION, ...
著者Miron, S, Legrand, P, Zinn-Justin, S.
登録日2023-10-04
公開日2024-06-19
最終更新日2024-07-17
実験手法X-RAY DIFFRACTION (3.461 Å)
主引用文献DMC1 and RAD51 bind FxxA and FxPP motifs of BRCA2 via two separate interfaces.
Nucleic Acids Res., 52, 2024

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件を2024-07-17に公開中

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